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  • 1
    Electronic Resource
    Electronic Resource
    The suitability of DNA cytometry for the prediction of the histological diagnosis in women with abnormal cervical smears (1996)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 103 (1996), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To analyse the suitability of DNA cytometry for predicting the histological diagnosis in women with cervical dyskaryosis.Design Survey with the use of diagnostic information to revise disease probability.Setting Colposcopy clinic of a university hospital.Participants One hundred and ten women with two mildly or moderately dyskaryotic cervical smears and 98 women with one severely dyskaryotic smear.Interventions DNA cytometric analysis using cytocentrifuge preparations of single cell suspensions from a cervical scrape. The main DNA cytometric parameter was N5C (i.e. the absolute number of cells with a DNA content of more than 5C on a given surface with a predefined cell density).Main outcome measure The probability of finding CIN II or worse. On arbitrary grounds, a positive test should point to a probability of 85% or higher.Results In the patients with cervical neoplasia, the value of N5C increased significantly with an increasing CIN grade (P 〈 0.001). In the patients with one severely dyskaryotic smear and in those with two mildly or moderately dyskaryotic smears, the prior probability of finding CIN II or worse was 94% and 53%, respectively. Therefore, DNA cytometric analysis might be particularly useful in women with mild or moderate dyskaryosis; further analysis was restricted to this group. All of the women in whom the N5C value was higher than 52 were diagnosed as having CIN II or worse. Only 16 (14.5%) of the 110 women had an N5C value of 52 or higher. When the N5C value was 27, the probability of finding CIN II or worse was estimated to be 85%. Only 28 (25%) patients had an N5C value of 27 or higher.Conclusions DNA cytometry produced significant diagnostic information, as was shown by the relation between N5C and the histological diagnosis. However, the N5C value could not discriminate sufficiently between women with CIN II or worse and CIN I or better. Therefore, the management of individual patients with cytological abnormalities cannot be based on the results of DNA cytometric analysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1996.tb09742.x
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  • 2
    Electronic Resource
    Electronic Resource
    Atypical mitotic figures and the mitotic index in cervical intraepithelial neoplasia (1995)
    Springer
    Virchows Archiv 427 (1995), S. 139-144 
    Details
    ISSN: 1432-2307
    Keywords: Mitoses ; Atypical mitotic figures ; Cervical neoplasia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We surveyed cervical intraepithelial neoplasia (CIN) to quantify the proliferation rate and the presence of normal and atypical mitotic figures. In the cervical tissue specimens of 127 women with CIN, the area with the highest cell proliferation was identified and, at that site, the proliferation rate was assessed by calculating the mitotic index (MI). Lesions with an MI 〈2 were not considered further. In the area with the highest proliferation rate, 228 mitoses were classified into one of the following groups: normal mitotic figures (NMFs), lag-type mitoses (LTMs) comprising three group metaphases (3GMs), two group metaphases (2GMs) and other lag-type mitoses (OLTMs), multipolar mitoses (MPMs) comprising tripolar mitoses (3PMs) and quadripolar mitoses (4PMs), and other atypical mitotic figures (OAMFs). The median value of the MI increased significantly from 3 in CIN I through 4 in CIN II to 9 in CIN III (P〈0.001). The occurrence of the different LTMs was mutually correlated. The frequency of LTMs increased significantly with increasing CIN grade (P〈0.001), whereas the frequency of NMFs decreased significantly with increasing CIN grade (P〈0.001). The frequency of OAMFs was not related to CIN grade (P=0.94). MPMs were present in low numbers in a minority of the lesions. Spearman's rank correlation coefficient (with 95% confidence limits) between the MI and the number of LTMs, OAMFs and NMFs was 0.66 (0.53; 0.75), −0.14 (−0.32; 0.05) and −0.51 (−0.63; −0.35), respectively. Increasing CIN grade is associated with increasing MI, increasing numbers of LTMs, and decreasing numbers of NMFs. MPMs are very rare events in CIN. The abundant presence of OAMFs seems to be independent of CIN grade and MI.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00196518
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    Paper (German National Licenses)
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