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  • 1
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Qualitätssicherung ; Schizophrenie ; Ratingskalen ; Interrater-Reliabilität ; PANSS ; Rater-Training ; Key words Quality assurance ; Schizophrenia ; Positive symptoms ; Negative symptoms ; Interrater reliability ; PANSS ; Rater training
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The present analysis comprises 3 studies on the interrater reliability of the Positive and Negative Syndrome Scale for Schizophrenia (PANSS; German version). To our knowledge this is the first empirical report on interrater reliability and on results of rater training of the German version of the PANSS despite the widespread use of the scale. In a total of 47 training participants with different clinical experience standardized PANSS rater training was carried out and subsequently evaluated. Therefore, concordance rates with an expert standard (C) and weighted coefficients kappa (κw) were calculated. As a main outcome of the studies, at least 3 training sessions were necessary but also sufficient to reach acceptable interrater reliability of the PANSS (C 〉 80%, kw 〉 0,60). In training participants with low psychiatric experience the level of interrater reliability of schizophrenic negative symptoms did not reach the results of positive symptoms after the training. Despite some conceptual limitations with respect to negative symptoms, the German version of the PANSS seems highly suitable to assess a broad spectrum of schizophrenic psychopathology in a reliable and economic manner. The present results also underline the practicability of our recommendations for conducting PANSS rater training in the clinical and scientific field as part of quality control and quality assurance in psychopathological assessment.
    Notes: Zusammenfassung Die vorliegende Arbeit umfasst 3 Untersuchungen zur Interrater-Reliabilität der deutschen Version der “Positive and Negative Syndrome Scale for Schizophrenia” (PANSS). Zur Interrater-Reliabilität und Trainierbarkeit der PANSS liegen im deutschen Sprachraum trotz der weiten Verbreitung der Skala bisher keine empirischen Daten vor. Bei 3 Stichproben mit insgesamt 47 Teilnehmern unterschiedlicher klinischer Erfahrung wurde ein standardisiertes PANSS-Rater-Training durchgeführt und evaluiert. Als Qualitätsmaße für das Training wurden die Übereinstimmung mit einem Expertenstandard (K) und gewichtete Kappa-Koeffizienten (κw) berechnet. Als ein Hauptergebnis lässt sich feststellen, dass zur Erreichung hinreichend akzeptabler Beurteilerübereinstimmungen (K 〉 80%, kw 〉 0,60) in der PANSS-Gesamtskala zumindest 3 Sitzungen notwendig, aber auch hinreichend sind. Bei psychiatrisch unerfahrenen Beurteilern gelang die Übereinstimmung bezüglich des Vorliegens und der Schwere schizophrener Negativsymptome auch nach mehreren Trainingssitzungen nicht mit der gleich hohen Güte wie bei Positivsymptomen. Die PANSS ist trotz gewisser konzeptueller Schwächen im Bereich der Negativsymptomatik auch in ihrer deutschen Version geeignet, ein breites Spektrum psychopathologischer Symptome reliabel und ökonomisch zu erfassen. Die Ergebnisse unterstreichen auch die Praktikabilität des vorgeschlagenen Vorgehens für die Durchführung von PANSS-Rater-Trainings im klinischen und wissenschaftlichen Bereich im Rahmen der Qualitätssicherung psychopathologischer Erfassungen.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 245 (1962), S. 71-72 
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Naturwissenschaften 4 (1916), S. 73-78 
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-2072
    Keywords: Key words Microstructure ; Sleep EEG ; Spectral power analysis ; Paroxetine ; Healthy subjects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Paroxetine is a selective and potent serotonin reuptake inhibitor and its efficacy for the treatment of depression has been proven. Under acute and subchronical treatment regimens, disturbances of the regular sleep pattern are a reported side effect of the drug. The present study was therefore performed to investigate the impact of subchronic treatment with the selective serotonin reuptake inhibitor paroxetine on the microstructure of the sleep EEG. The study especially addressed the question of subchronic effects of paroxetine medication (30 mg/day) in eight healthy male volunteers in a double blind, placebo-controlled crossover design. Conventional sleep EEG parameters and a spectral power analysis for different sleep stages after 4 weeks of treatment were computed. Additionally, the correlation of certain EEG rhythms across the night was calculated in order to detect subtle dynamical EEG alterations, not necessarily obvious when regarding conventional EEG analysis. Although we could not detect any alterations of the spectral power values in certain frequency bands either during NREM nor during REM sleep following subchronic paroxetine medication, the dynamical EEG attributes across the night revealed a significant enhancement of the correlation between certain EEG rhythms mainly during NREM sleep.
    Type of Medium: Electronic Resource
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