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  • 1
    Electronic Resource
    Electronic Resource
    Effect of dipyridamole with or without aspirin on urine protein excretion in patients with membranous glomerulonephritis (1992)
    Springer
    European journal of clinical pharmacology 43 (1992), S. 307-309 
    Details
    ISSN: 1432-1041
    Keywords: Dipyridamole, Acetylsalicylic acid, Urinary protein excretion ; antiplatelet agents, platelet aggregation, thromboxane synthesis, glomerulonephritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The antiproteinuric effect of the antiplatelet agent dipyridamole has been assessed after inhibiton of thromboxane B2 (TxB2) synthesis in 8 patients with confirmed membranous glomerulonephritis. There were three study periods, each of 30 days, and 45 days apart, namely a washout period, treatment with dipyridamole 300 mg/d, and dipyridamole 225 mg/d plus aspirin 150 mg/d. On Days 1 and 30 of each study period serum and urine creatinine, 24-h excretion of protein, creatinine clearance, platelet aggregometry on whole blood and serum TxB2 were measured. Treatment with dipyridamole alone or with aspirin produced significant inhibition of platelet aggregation and a fall in 24-h protein excretion; the latter amounted to 54% with dipyridamole alone and 56 % with dipyridamole plus aspirin (NS). Dipyridamole plus aspirin caused an 82 % reduction in serum TxB2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02333029
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of triflusal and its main metabolite HTB on platelet interaction with subendothelium in healthy volunteers (1995)
    Springer
    European journal of clinical pharmacology 47 (1995), S. 497-502 
    Details
    ISSN: 1432-1041
    Keywords: Triflusal ; Acetylsalicylic acid ; platelet activation ; platelet-vessel wall interaction ; subendothelium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract The ex vivo effect of triflusal and acetylsalicylic acid (ASA) on platelet interaction with the subendothelium using the Baumgartner perfusion system (wall shear rate 350 s−1) was assessed in blood from 10 healthy volunteers who given a 15-day course of triflusal 600 mg per day and ASA 400 mg per day in a crossover trial. The percentage of platelets on the subendothelium showed a decrease of 62% in samples from subjects on ASA and a decrease of 93% in those from subjects on triflusal (P〈0.005). The percentage of the subendothelial surface covered by platelets was reduced by 23.3% after treatment with ASA, mainly due to inhibition of aggregates (75.2%), and by 29.9% after treatment with triflusal, mainly due to inhibition of aggregates (89.6%) and of adhesion (25%). The subendothelial surface covered by activated platelets (adhesions and thrombi) showed 32.5% inhibition after treatment with triflusal and 11.6% after treatment with ASA (P〈0.043 vs. triflusal). In the in vitro experiments, 10 μmol·l−1 triflusal did not modify the percentage of the subendothelium covered by platelets. HTB 1 mmol·l−1 inhibited adhesion (26%) and aggregates (18%). We conclude that HTB participates in the ex vivo effects of triflusal on the platelet-subendothelium interaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00193701
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Bronchodilator effect and serum theophylline level after combined treatment with fenoterol and theophylline in reversible chronic airflow obstruction (1988)
    Springer
    European journal of clinical pharmacology 35 (1988), S. 669-671 
    Details
    ISSN: 1432-1041
    Keywords: asthma ; theophylline ; fenoterol ; sustained-release formulation ; serum theophylline levels ; bronchodilator effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Sustained-release theophylline 10.1 mg/kg b.d. was given with placebo or fenoterol 2.5 mg t.d.s. to 12 patients with chronic airway obstruction. Fenoterol did not significantly affect the steady-state serum theophylline trough level (11.84 µg/ml for fenoterol vs 11.10 µg/ml for placebo). Addition of fenoterol produced no further increase in spirometric function nor in clinical status.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637605
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    Paper (German National Licenses)
    Fulltext
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