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  • 1
    Electronic Resource
    Electronic Resource
    THE ACCUMULATION OF ARACHIDONATE AND DOCOSAHEXAENOATE IN THE DEVELOPING RAT BRAIN (1972)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 19 (1972), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: —Fatty acids typical of grey matter lipids (C20:4 and C22:6) and of myelin lipids (C20:1 and C24:1) were estimated in developing rat brains. The polyenoic fatty acids (C20:4 and C22:6) are synthesized from the essential fatty acids (C18:2 and C18:3). The results showed that more than 50 per cent of the adult content of the brain polyenoic acids were laid down by day 15. In contrast, the fatty acids characteristic of myelin lipids did not appear in significant quantities until after this time. These findings distinguish biochemically the different periods of brain development associated firstly with cell division (formation of neurons and glial cells) and secondly with myelination. It is of special interest that the period of cell proliferation is accompanied by the appearance in brain lipids of long-chain polyenoic acids derived from the essential fatty acids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1972.tb06219.x
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  • 2
    Electronic Resource
    Electronic Resource
    Role of N-6 and N-3 Fatty Acids in the Dietary Treatment of Metabolic Disorders (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 683 (1993), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1993.tb35723.x
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  • 3
    Electronic Resource
    Electronic Resource
    EFFECTS OF ARACHIDONATE DEFICIENCY ON ENDOTHELIUM- DEPENDENT VASCULAR REACTIONS (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 14 (1987), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The release of endothelium-derived relaxing factor (EDRF), which appears to be impaired in vessels chronically exposed to hypertension, may involve mobilization of arachidonate from phospholipids. In this study the effects of arachidonate deficiency on endothelium-dependent responses were examined in rat isolated aorta.2. Weanling rats were fed an essential fatty acid-deficient (EFAD) diet for 8 weeks which reduced plasma and aortic phospholipid arachidonate content from 17 to 1.8% and from 21 to 8%, respectively. After this time the rats were killed and the reactivity of aortic rings was studied in organ baths.3. In aortic rings from control rats the concentration-response curves for the contractile action of phenylephrine were shifted to the left 3.5-fold by removal of the endothelium, and the maximum was not altered.4. In contrast, in EFAD rings with endothelium, the maximal vasoconstriction to phenylephrine was less than in control rings, and removal of the endothelium increased the maximum (from 1.9±0.2 to 3.2±0.1 g, P 〈 0.05) and reduced the EC50 7-fold.5. In EFAD rings precontracted with phenylephrine (0.3 μml/l) the relaxations produced by the endothelium-dependent dilator acetylcholine were not significantly different from those produced in control rings. The dilator actions of sodium nitroprusside were also similar in EFAD and control rings.6. Thus, endothelium-dependent dilatation in the aorta is not impaired by partial depletion of phospholipid arachidonate. However, contractile responses to α-adrenoceptor agonists are depressed by spontaneously released EDRF in rat aorta, so that the results suggest that depletion of phospholipid arachidonate either augments spontaneous release of EDRF, or impairs EDRF inactivating mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1987.tb00366.x
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  • 4
    Electronic Resource
    Electronic Resource
    Inability of the cat to desaturate essential fatty acids (1975)
    [s.l.] : Nature Publishing Group
    Nature 258 (1975), S. 171-173 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Table 1 Fatty acid analyses of diets fed* Diet Fatty acid Control SBOL SSO 10:0+12:0+14:0 4.1 7.8 6.7 16:0+16:1 27.5 10.3 7.8 18:0 13.5 13.7 1.7 18:1 36.9 19.4 17.4 18:2o)6t 7.2 40.8 63.6 18:3co3f 0.9 16.8 0.9 20:0 +20:1 1.9 - - 20:2 0)6 J 0.1 - - 20:3 0)6 J 0.1 - - ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/258171a0
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  • 5
    Electronic Resource
    Electronic Resource
    Disturbed handling of ascorbic acid in diabetic patients with and without microangiopathy during high dose ascorbate supplementation (1991)
    Springer
    Diabetologia 34 (1991), S. 171-175 
    Details
    ISSN: 1432-0428
    Keywords: Ascorbic acid ; dehydroascorbic acid ; diabetes mellitus ; free radical activity ; oxidative stress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Abnormalities of ascorbic acid metabolism have been reported in experimentally-induced diabetes and in diabetic patients. Ascorbate is a powerful antioxidant, a cofactor in collagen biosynthesis, and affects platelet activation, prostaglandin synthesis and the polyol pathway. This suggests a possible close interrelationship between ascorbic acid metabolism and pathways known to be influenced by diabetes. We determined serum ascorbic acid and its metabolite, dehydroascorbic acid, as indices of antioxidant status, and the ratio, dehydroascorbate/ascorbate, as an index of oxidative stress, in 20 matched diabetic patients with and 20 without microangiopathy and in 22 age-matched control subjects. Each study subject then took ascorbic acid, 1 g daily orally, for six weeks with repeat measurements taken at three and six weeks. At baseline, patients with microangiopathy had lower ascorbic acid concentrations than those without microangiopathy and control subjects (42.1±19.3 vs 55.6±20.0, p〈0.01, vs 82.9±30.9 μmol/l, p〈0.001) and elevated dehydroascorbate/ascorbate ratios (0.87±0.46 vs 0.61±0.26, p〈0.01, vs 0.38±0.14, p〈0.001). At three weeks, ascorbate concentrations rose in all groups (p〈0.0001) and was maintained in control subjects (151.5± 56.3 μmol/l), but fell in both diabetic groups by six weeks (p〈0.01). Dehydroascorbate/ascorbate ratios fell in all groups at three weeks (p〈0.0001) but rose again in the diabetic groups by six weeks (p〈0.001) and was unchanged in the control subjects. Dehydroascorbate concentrations rose significantly from baseline in all groups by six weeks of ascorbic acid supplementation (p〈0.05). No significant changes were observed in fructosamine concentrations in any group during the study. Diabetes mellitus is associated with a major disturbance of ascorbic acid metabolism which is only partially corrected by ascorbate supplementation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00418271
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  • 6
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of meptazinol in man following repeated intramuscular administration (1982)
    Springer
    European journal of clinical pharmacology 23 (1982), S. 535-538 
    Details
    ISSN: 1432-1041
    Keywords: meptazinol ; pharmacokinetic ; dosage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A study was performed in 6 healthy volunteers to determine whether 50 mg intramuscular doses of meptazinol repeated four hourly for 24 h would lead to accumulation of the drug. The first dose of meptazinol was rapidly absorbed with a subsequent mean (± SD) elimination half-life of 1.6±0.33 h. This value was unaffected by the administration of intermediate doses. There was no significant accumulation of the drug; 95% of the steady-state plasma concentration was achieved after a mean (± SD) of 1.9±0.39 and 99% after a mean (± SD) of 2.9±0.63 doses. These findings are consistent with the theoretical prediction for a rapidly absorbed drug with a plasma elimination half-life of 1.6 h. No clinically relevant changes were seen in pulse blood pressure, haematological or biochemical screens. Reported side effects were of a subjective and minor nature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637502
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  • 7
    Electronic Resource
    Electronic Resource
    Fluid source and thermal history of an epithermal vein deposit, Owen Lake, central British Columbia: evidence from bitumen and fluid inclusions (1992)
    Springer
    Mineralium deposita 27 (1992), S. 219-225 
    Details
    ISSN: 1432-1866
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Fluid source and thermal history are determined for the barite and bitumen-bearing, early Eocene (ca. 50 Ma) polymetallic, epithermal veins of the Owen Lake deposit, central British Columbia, Canada. Carbon isotopic values for the bitumen are highly negative (δ 13 C ca −29%) indicating a probable terrigenous source, which may be 1 no older than Late Cretaceous or, 2 Eocene plant-fossil-bearing units stratigraphically above the Owen Lake deposit. Heat generated by suspected magmatic activity resulted in downflow of meteoric water and upflow of hydrothermal water, mixing at the site of deposition. Aqueous and hydrocarbon fluid inclusions occur within barite; Th of both types of inclusions indicate a temperature range of approximately 100° to 180 °C. Tm(ice) of aqueous inclusions range from −4.5 to −0.2 °C indicating a range of 7.2 to 0.4 equivalent weight percent NaCl. Parageneticaly younger bitumen has a vitrinite reflectance of 0.6% indicating maturation level in the temperature range of 80° to 120 °C, strongly suggesting a cooling thermal regime during barite and bitumen deposition, consistent with a late stage paragenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00202546
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  • 8
    Electronic Resource
    Electronic Resource
    Re-evaluation of lead isotopic data, southern Massif Central, France (1993)
    Springer
    Mineralium deposita 28 (1993), S. 122-128 
    Details
    ISSN: 1432-1866
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Three independent Pb isotope homogenizing processes operating on large volumes of rock material during limited intervals in the Phanerozoic have been used to define a unique evolutionary curve for rock and ore lead isotopic compositions of the southern Massif Central, France. The model is $$\begin{gathered}{\text{ x}}_{\text{t}} = 18.641{\text{ }} - {\text{ 9}}{\text{.56(e}}^{{\text{L1*t}}} - 1{\text{)}} \hfill \\{\text{y}}_{\text{t}} = 15.678{\text{ }} - {\text{ 0}}{\text{.06934(e}}^{{\text{L2*t}}} - 1{\text{)}} \hfill \\{\text{ z}}_{\text{t}} = 38.701{\text{ }} - {\text{ 30}}{\text{.8(e}}^{{\text{L3*t}}} - 1{\text{)}} \hfill \\\end{gathered}$$ where xt, yt and zt are the calculated isotopic ratios (206Pb/204Pb, 207Pb/204Pb and 208Pb/204Pb respectively) at time t years ago and L1, L2 and L3 are the decay constants of 238U, 235U and 232Th respectively. The model gives the following ages for averages of the three sets of data used in its generation: age of mineralization for carbonate-hosted lead-zinc ore of Les Malines, ca. 150 Ma; emplacement of the Saint-Guiral-Liron granite, ca. 290 Ma; and an estimated average age of a group of Cambrian syngenetic deposits, ca. 520 Ma. These ages are in close agreement with ages determined by independent methods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00196336
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  • 9
    Electronic Resource
    Electronic Resource
    Reviews (1971)
    Springer
    Mathematical geology 3 (1971), S. 383-391 
    Details
    ISSN: 1573-8868
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02083363
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  • 10
    Electronic Resource
    Electronic Resource
    Geostatistical investigation of the Kutcho Creek chrysotile deposit, Northern British Columbia (1978)
    Springer
    Mathematical geology 10 (1978), S. 273-288 
    Details
    ISSN: 1573-8868
    Keywords: geostatistics ; mining geology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Mathematics
    Notes: Abstract The Kutcho Creek asbestos deposit, owned by Cassiar Asbestos Corporation Ltd., has been sampled by two major exploratory programs that have provided two sets of grade data—one from the horizontal direction (wall readings) and one from the vertical direction (diamond drill cores). These data (percentage chrysotile by volume) were divided into well-defined groups on the basis of location and sample continuity, and experimental variograms for percentage of fiber content were calculated for each group. Horizontal data were all oriented in directions roughly parallel to the trend of an elongate serpentinite zone containing local centers rich in chrysotile veinlets. Spherical variogram models fitted to horizontal and vertical data sets are as follows: Vertical: $$\begin{gathered} \gamma (h) = 0.27 m^2 + 0.44 m^2 [(3h/70) - (h^3 /85,750)] h \leqslant a \hfill \\ \gamma (h) = 0.71 m^2 h \geqslant a \hfill \\ \end{gathered}$$ Horizontal: $$\begin{gathered} \gamma (h) = 0.27 m^2 + 1.20 m^2 [(h/60) - (h^3 /729,000)] h \leqslant a \hfill \\ \gamma (h) = 1.47 m^2 h \geqslant a \hfill \\ \end{gathered}$$ Wherem is the mean value of data used in the construction of a variogram,h is a lag (sample spacing), anda is the range over which the grade is autocorrelated. These two one-dimensional models can be combined to a two-dimensional model with the form γ(h)=γ(r)+γ(x) where γ(r) is an isotropic component (equivalent to the vertical model above) and γ(x) is a zonal component in the horizontal direction (equivalent to the difference between the horizontal and vertical models above). This general model describes data throughout the entire serpentinite zone in a satisfactory manner but, of course, does not contain information in the third dimension, and, thus, cannot be used as a basis for grade and tonnage calculations and corresponding error estimates. Nevertheless, the analysis has illustrated the potential of variogram analysis for such tonnage and grade calculations. Furthermore, the study has provided limiting two-dimensional information on the geometry of chrysotile-rich zones within the serpentinite belt, information that can be used to advantage in planning future exploratory drilling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02048491
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