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  • 1
    Electronic Resource
    Electronic Resource
    Electron paramagnetic resonance and ultraviolet-visible spectroscopic evidence for copper porphyrin in actinomycete melanins (1998)
    Springer
    Biology and fertility of soils 26 (1998), S. 341-345 
    Details
    ISSN: 1432-0789
    Keywords: Key words Copper porphyrin ; Actinomycete melanins ; Electron paramagnetic resonance spectroscopy ; Brazilian soils
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract The coordination chemistry of iron (III) (Fe3+) and copper (II) (Cu2+) in melanins synthesized by seven actinomycetes isolated from Brazilian latosol soils under savanna (cerrado) vegetation was investigated using electron paramagnetic resonance (EPR) and ultraviolet-visible (UV-Vis) spectroscopy. The EPR spectra indicated the presence of Cu2+ ions bound to oxygenated and nitrogenous functional groups, and rhombic coordinated Fe3+ ions. In some of the actinomycete melanins the EPR hyperfine splitting of Cu+2 ion complexes was well resolved, and indicated four magnetically equivalent nitrogen atoms in a plane. This result suggested the presence of Cu+2 porphyrin complexes, which was confirmed by Soret bands in the 400-nm region of the UV-Vis spectra. The concentration of Mn in actinomycete melanins, determined by inductively coupled plasma atomic emission spectroscopy, was lower than those of Cu and Fe.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003740050386
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  • 2
    Electronic Resource
    Electronic Resource
    Genetic analysis of immunomodulating factors in sporadic Parkinson's disease (2000)
    Springer
    Journal of neural transmission 107 (2000), S. 553-562 
    Details
    ISSN: 1435-1463
    Keywords: Keywords: Parkinson's disease, genetics, immunomodulation, tumor necrosis factor alpha.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. Immunomodulating factors have been shown to play a role in the pathogenesis of Parkinson's disease (PD) by biochemical methods. In order to investigate functionally important genes of the tumor necrosis factor alpha (TNFα) pathway we studied the frequency of DNA polymorphisms in the interleukin 6 (IL6), the TNFα, and the TNFα receptor 1 (TNFR1) genes in 264 sporadic German PD patients and in 183 age and sex matched German healthy controls. Analyzing the TNFα-308 polymorphism we found heterozygous individuals carrying alleles 1 and 2 more frequently in patients with a relative risk of 1.56 (p = 0.046, pc = 0.13, χ2 = 3.98). In contrast, the frequency of the B/2 haplotype described by the TNFR1−609 and TNFRI+36 polymorphisms was significantly decreased in our PD patients group (p = 0.0097, pc = 0.048, χ2 = 6.69) with a relative risk reduced to 0.52. Our results suggest an involvement of immunomodulating factors in the pathogenesis of sporadic PD as revealed by a molecular genetic approach.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007020070078
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Microsatellite evolution in the 5′ UTR of theHLA-F gene (1998)
    Springer
    Human evolution 13 (1998), S. 57-64 
    Details
    ISSN: 1824-310X
    Keywords: microsatellite ; evolution ; population genetics ; polypurine blocks ; mutation ; HLA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In order to understand evolutionary aspects of the highly polymorphicHLA-F microsatellite (heterozygosity〉90%), several alleles of primates were characterized. 576 meioses from 35 CEPH families were investigated for regular transmission. Furthermore 364 healthy, non-related individuals belonging to four populations from distant ethnic groups were analysed to determine the applicability of this locus in population studies. Sequencing revealed alternate (GAGGAA)n blocks spaced by (GAA)n repeats in all primates analysed. The mutation rate of this locus amounts to 1.5%. The mutational patterns follow approximately the one step mutation model. Differential analysis suggests that mutation rates depend on the repeat length. Paternal mutation rates exceed maternal ones. The presence of both allele classes in all human populations investigated indicates that this polymorphism predated raciation. Evidence is provided that the short alleles originated from the longer ones by deletion. Finally the differential analysis of each allele class corroborates the biological history of the studied populations as traced by other genetic markers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02439369
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    Paper (German National Licenses)
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