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  • 1
    Electronic Resource
    Electronic Resource
    Electrocardiographic evidence for a cardioprotective effect of nifedipine during experimental hypercalcemia (1982)
    Springer
    Basic research in cardiology 77 (1982), S. 12-25 
    Details
    ISSN: 1435-1803
    Keywords: hypercalcemia ; cardiomyopathy ; cardioprotection ; nifedipine ; electrocardiogram ; calcium antagonist ; guinea-pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Um den Effekt von Nifedipin auf die hyperkalzämischen Veränderungen des Elektrokardiogramms zu untersuchen, wurde an Meerschweinchen eine stetig zunehmende Hyperkalzämie durch kontinuierliche Kalziumglukonat-Infusion erzeugt, welche bis zum Herzstillstand andauerte. Während der Versuchszeit wurde das Elektrokardiogramm (Ekg) kontinuierlich aufgenommen. Die Elektrokardiogramme von Tieren mit und ohne Vorbehandlung mit Nifedipin (Adalat®) wurden miteinander verglichen. Die typischen hyperkalzämischen Veränderungen im Ekg verstärkten sich mit zunehmendem Serumkalziumspiegel. Steigende Kalium- und Magnesiumspiegel im Serum deuteten auf eine zunehmende Zellschädigung mit Ausstrom dieser vorwiegend intrazellulären Ionen hin. Eine Vorbehandlung mit Nifedipin beeinflußte die hyperkalzämiebedingte Bradykardie und $$\overline {PQ} $$ -Verlängerung außer einem geringen und vorübergehenden Effekt während relativ niedriger Kalziumspiegel nicht signifikant. Auf die hyperkalzämische Verkürzung der $$\overline {ST} $$ -Strecke und des $$\overline {QT} $$ -Intervalls hingegen entfaltete Nifedipin eine ausgeprägt normalisierende Wirkung trotz der unveränderten Ausbildung einer Hyperkalzämie. Dementsprechend waren nach Vorbehandlung mit Nifedipin der zelluläre Kalium- und Magnesiumausstrom deutlich reduziert und die Überlebenszeit während der Kalziuminfusion deutlich verlängert. Diese elektrophysiologischen Befunde stehen im Einklang mit unseren früheren zytochemischen Untersuchungen, in denen ein protektiver Effekt von Nifedipin gegen eine hyperkalzämieinduzierte Überladung der intrazellulären Kalziumdepots in Myokardzellen nachgewiesen werden konnte. Ob dieser kardioprotektive Effekt von Nifedipin bei Hyperkalzämie therapeutisch bei einer hyperkalzämischen Krise genutzt werden kann, muß in klinischen Studien geklärt werden.
    Notes: Summary To investigate the effect of nifedipine on hypercalcemic electrocardiographical alterations, steadily increasing hypercalcemia was induced in guinea-pigs by continuous calcium gluconate infusion until cardiac arrest occurred. During the experimental time the electrocardiograms were continuously recorded and compared in animals with and without pretreatment by nifedipine (Adalat®). The hypercalcemia-induced electrocardiographical alterations intensified during increasing serum calcium levels. Ascending serum potassium and magnesium levels indicated increasing cell damage with a leak of these mainly intracellular ions. Pretreatment by nifedipine did not significantly influence the hypercalcemia-induced bradycardia and augmentation of the P-Q interval except a small and transient effect during relatively low calcium levels. The drug, however, exerted a distinct normalizing effect on hypercalcemic reduction of the S-T segment and the Q-T interval despite of an unaltered development of hypercalcemia. Accordingly, the cellular potassium and magnesium leaks were markedly reduced and the survival time during calcium infusion was significantly prolonged after nifedipine pretreatment. These electrophysiological data are in agreement with our previous cytochemical studies, which showed a protective effect of nifedipine against hypercalcemia-induced overloading of the cellular calcium depots in myocardial cells. Whether this cardio-protective effect of nifedipine during hypercalcemia can be used therapeutically in hypercalcemic crisis, has to be examined in clinical studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01908127
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  • 2
    Electronic Resource
    Electronic Resource
    Muon Spin Relaxation Study of Defect Reactions in Electron-Irradiated Nb, Ta, and Al (1987)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 15-18 (Jan. 1987), p. 71-80 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/00/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.15-18.71.pdf
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  • 3
    Electronic Resource
    Electronic Resource
    Renal proteinases and kidney hypertrophy in experimental diabetes (1994)
    Springer
    Diabetologia 37 (1994), S. 567-571 
    Details
    ISSN: 1432-0428
    Keywords: IDDM ; streptozotocin ; tubules ; glomeruli ; collagenase ; gelatinase ; cathepsins ; hypertrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary IDDM is associated with an increase in kidney size, which is due to cellular hypertrophy and progressive matrix accumulation within the glomerulus and throughout the tubulointerstitium. The present study addressed the potential role of cysteine and metalloproteinases in renal hypertrophy of short-term diabetes. Three weeks after induction of streptozotocin diabetes in rats, intraglomerular gelatinase activity (streptozotocin: 23±4 vs control: 44±3 mU/μg DNA) and cathepsin L + B activity (streptozotocin: 6.7±0.8 vs control: 9.3±0.7 U/μg DNA) were significantly decreased. Insulin treatment completely prevented the decline in glomerular proteinase activity (gelatinase: 37±6 mU/μg DNA; cathepsin L + B: 9.6±0.9 U/μg DNA). In isolated proximal tubules a similar pattern of enzyme activity could be observed. Three weeks of diabetes caused a significant decline in cathepsin L + B activity (streptozotocin: 28±2 vs control: 37±3 U/μg DNA). Insulin treatment again prevented the decline in these tubular proteinase activities. In parallel, kidney weight increased by 22% and glomerular protein/DNA ratio rose by 17% in untreated diabetic rats. Diabetic rats receiving insulin displayed a normal glomerular protein/DNA ratio and the kidney weight was increased by only 5%. These results show that renal hypertrophy of early diabetes is closely associated with a decline in both glomerular and tubular proteinase activity. Adequate insulin substitution prevented renal hypertrophy and the reduction in proteinase activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403374
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  • 4
    Electronic Resource
    Electronic Resource
    Renal proteinases and kidney hypertrophy in experimental diabetes (1994)
    Springer
    Diabetologia 37 (1994), S. 567-571 
    Details
    ISSN: 1432-0428
    Keywords: Key words IDDM, streptozotocin, tubules, glomeruli, collagenase, gelatinase, cathepsins, hypertrophy.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary IDDM is associated with an increase in kidney size, which is due to cellular hypertrophy and progressive matrix accumulation within the glomerulus and throughout the tubulointerstitium. The present study addressed the potential role of cysteine and metalloproteinases in renal hypertrophy of short-term diabetes. Three weeks after induction of streptozotocin diabetes in rats, intraglomerular gelatinase activity (streptozotocin: 23±4 vs control: 44±3 mU/µg DNA) and cathepsin L+B activity (streptozotocin: 6.7±0.8 vs control: 9.3±0.7 U/µg DNA) were significantly decreased. Insulin treatment completely prevented the decline in glomerular proteinase activity (gelatinase: 37±6 mU/µg DNA; cathepsin L+B: 9.6±0.9 U/µg DNA). In isolated proximal tubules a similar pattern of enzyme activity could be observed. Three weeks of diabetes caused a significant decline in cathepsin L+B activity (streptozotocin: 28±2 vs control: 37±3 U/µg DNA). Insulin treatment again prevented the decline in these tubular proteinase activities. In parallel, kidney weight increased by 22 % and glomerular protein/DNA ratio rose by 17 % in untreated diabetic rats. Diabetic rats receiving insulin displayed a normal glomerular protein/DNA ratio and the kidney weight was increased by only 5 %. These results show that renal hypertrophy of early diabetes is closely associated with a decline in both glomerular and tubular proteinase activity. Adequate insulin substitution prevented renal hypertrophy and the reduction in proteinase activity. [Diabetologia (1994) 37: 567–571]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403374
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  • 5
    Electronic Resource
    Electronic Resource
    Differential regulation of glomerular gelatinase B (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in obese Zucker rats (1997)
    Springer
    Diabetologia 40 (1997), S. 1035-1043 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Glomerulosclerosis ; matrix metalloproteinase ; tissue inhibitor of metalloproteinases ; obese Zucker rat.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The obese Zucker rat represents a model of obesity combined with insulin resistance and hyperlipidaemia, which over a period of several months develops spontaneous glomerulosclerosis. The present study addressed the question as to whether glomerular sclerosis was associated with alterations in the degradation of matrix components. In the early phase (up to 6 months) glomeruli from obese rats displayed increased total collagen content (+ 64 %) and decreased gelatinolytic activity (− 34 %) as compared to lean control animals. This decline in glomerular gelatinolytic activity was due to a reduction in gelatinase B [matrix metalloproteinase (MMP)-9]. Glomerular MMP-9 mRNA was reduced 4.6 ± 0.6-fold (n = 3; p 〈 0.05), MMP-9 protein was not detectable by Western blotting and MMP-9 activity was considerably suppressed in gelatin zymograms. MMP-2, in terms of mRNA expression and activity, was unchanged. Tissue inhibitor of metalloproteinases (TIMP)-1 mRNA expression, TIMP-1 protein (immunohistochemistry) and TIMP-1 activity (reverse zymography) were enhanced in glomeruli from obese rats, while TIMP-2 mRNA remained unchanged. Moreover, mRNA for the α1 IV collagen chain was 2.1 ± 0.8-fold higher in glomeruli isolated from obese animals (n = 3; p 〈 0.05). These findings indicate that matrix expansion in glomeruli from obese Zucker rats is due to both enhanced synthesis of matrix components as well as reduced degradation by matrix metalloproteinases. Apparently the latter effect is based on a reduction in MMP-9 and up-regulation of its inhibitor TIMP-1. [Diabetologia (1997) 40: 1035–1043]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050785
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  • 6
    Electronic Resource
    Electronic Resource
    Computer-Analysen der Erythrocytenvolumenverteilungskurven (1980)
    Springer
    Journal of molecular medicine 58 (1980), S. 149-152 
    Details
    ISSN: 1432-1440
    Keywords: Erythrocyte ; Volume distribution curves ; Computer analysis ; Erythrocyten ; Volumenverteilungskurven ; Computeranalyse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im Gegensatz zur symmetrischen, normal verteilten Erythrocytendurchmesserkurve nach Price-Jones zeigt die Volumenverteilungskurve (VVK) der Erythrocyten einen asymmetrischen, rechtsschrägen Kurvenverlauf, der bei verschiedenen hämatologischen Erkrankungen unterschiedliche Formen annehmen kann. Es ist sowohl von differential-diagnostischer als auch von therapeutischer Bedeutung, diese unterschiedlichen Kurvenläufe objektiv vergleichen zu können. Wir entwickelten daher eine mathematische Beschreibung der VVK, die auf einer Überlagerung von 2 Gauß'schen Normalverteilungen beruht. Auf diese Art und Weise ließen sich mit Hilfe einer Computeranalyse bis auf eine Ausnahme für alle von insgesamt 271 gesunden und hämatologisch erkrankten Kindern und von 3 Erwachsenen mit einem elektronischen Zählgerät (Coulter Counter) gewonnenen Erythrocytenvolumenverteilungskurven die Kenngrößenm 1,m 2,s 1 unds 2 errechnen. Diese Charakterisierung der Kurvenverläufe mit nur 4 Kenngrößen gestattet auf einfache Weise einen quantitativen und qualitativen Vergleich verschiedener Volumenverteilungskurven.
    Notes: Summary The erythrocyte diameter curve of Price-Jones exhibits symmetrical, normal distribution. In contrast, the volume distribution curve of erythrocytes shows an asymmetrical course with some skewness to the right, which with different haematological diseases may vary. With respect to differential diagnosis as well as to therapy it is of importance to have available an objective means of comparing curves with different shapes. We therefore developed a mathematical determination of the volume distribution curves, which is derived from the overlapping of two Gaussian normal distribution curves. Volume distribution curves of erythrocytes were determined with an electronic particle counter (Coulter counter) in 271 healthy and haematologically affected children as well as in 3 adults. With only one exception all volume distribution curves of erythrocytes could be fitted using computer analysis and the constantsm 1,m 2,s 1 ands 2 were calculated. Characterisation of the curves with only these 4 constants allows a simple qualitative as well as quantitative comparison of different volume distribution curves.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01477272
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  • 7
    Electronic Resource
    Electronic Resource
    Die Glykoproteide im Serum und Urin bei chronischen Nierenerkrankungen (1963)
    Springer
    Journal of molecular medicine 41 (1963), S. 172-178 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Das Verhalten der Proteine und Glykoproteide im Serum und Urin wurde bei insgesamt 16 Patienten mit chronischen glomerulären Nicrenerkrankungen untersucht und mit den entsprechenden Befunden von 10 Normalpersonen in Relation gesetzt. Bei chronischen Glomerulonephritiden mit hypertoner Verlaufsform war neben einer mäßiggradigen Reduzierung des Gesamt-Eiweißwertes, die in einer Albuminerniedrigung zum Ausdruck kam, eine quantitative Erhöhung des Glucosamins und der proteingebundenen Hexosen nachweisbar. Die elektrophoretische Auftrennung erbrachte ebenso wie bei den Normalpersonen in allen Eiweißfraktionen Glykoproteide, wobei der Albuminanteil relativ gering und alpha2-Globulin den höchsten Gehalt an eiweißgebundenen Kohlenhydraten erkennen ließ. Für die Uroglykoproteide wird der gleiche glomeruläre Ausscheidungs-mechanismus wie für die Proteine angenommen, weil die Glykoproteidfraktionen im Elektrophoresediagramm dem sog. „Nephrosetyp der Eiweißausscheidung“ entsprechen. Besonders hochgradig war die Steigerung der Gesamt-Glykoproteide in der Patientengruppe mit chronischer Glomerulonephritis und nephrotischem Einschlag sowie bei den beiden Patienten mit Amyloidnephrose. Der Glykoproteidanteil in der alpha2-Globulinfraktion war exzessiv erhöht bei gleichzeitiger Erniedrigung im Albuminbereich. Im Urin wurden parallel zu den Proteinen die kleinmolekularen Glykoproteide bevorzugt ausgeschieden. Die Erhöhung der Glykoproteide dürfte bei chronischen Glomerulonephritiden Ausdruck eines gesteigerten Eiweißkatabolismus sein, wobei möglicherweise kontinuierlich ablaufende Zelldestruktionen beteiligt sein können.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01479428
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  • 8
    Electronic Resource
    Electronic Resource
    Geschlechtskrankheiten (1919)
    Springer
    Archives of dermatological research 125 (1919), S. 444-474 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01827080
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  • 9
    Electronic Resource
    Electronic Resource
    Hautkrankheiten (1920)
    Springer
    Archives of dermatological research 125 (1920), S. 943-984 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01843362
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  • 10
    Electronic Resource
    Electronic Resource
    Localization of the ribosomal RNA genes in Drosophila simulans (1980)
    Springer
    Chromosoma 79 (1980), S. 287-291 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In situ hybridization of cloned rRNA genes from Drosophila melanogaster to D. simulans metaphase chromosomes shows that in the tested wild type strains both sex chromosomes contain a nucleolus organizer region. Silver grain counts support the published data that the X chromosomal rRNA gene number is significantly higher than the Y chromosomal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00327320
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