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  • 1
    Electronic Resource
    Electronic Resource
    In vivo enzyme activity of purified human brain renin (1978)
    Springer
    Journal of molecular medicine 56 (1978), S. 43-45 
    Details
    ISSN: 1432-1440
    Keywords: Gehirnrenin ; Angiotensin ; Angiotensinogen ; Liquor cerebrospinalis ; Blutdruck ; Brain renin ; Angiotensin ; Angiotensinogen ; Cerebrospinal fluid ; Blood pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Cerebrospinal fluid (CSF) of rats contains high angiotensinogen concentrations. When 3500-fold purified renin from human brain was injected into the brain ventricles of rats, angiotensin I concentrations increased from undetectable levels to 147.9±18.8 fMol per ml CSF. In parallel, mean arterial blood pressure increased from 93±2.4 mm Hg to 107±3.7 mm Hg. The increase in blood pressure could be abolished by intraventricular administration of saralasin, a blocker of angiotensin II receptors. Intraventricular injection of cathepsin D had no effect on arterial blood pressure and the angiotensin I concentration in CSF remained below detection limits of the radioimmunoassay. We conclude that brain renin acts on endogenous brain angiotensinogen under physiological in vivo conditions to form angiotensin I. The latter is converted to angiotensin II and leads to biological effects, i.e. increase of blood pressure.
    Notes: Zusammenfassung Der Liquor cerebrospinalis von Ratten enthält Angiotensinogen in hoher Konzentration. Nach Injektion von 3500fach angereichertem menschlichem Gehirnrenin in die Hirnventrikel von Ratten stieg die Konzentration von Angiotensin I von unmeßbar niedrigen Werten auf 147,9±18,8 fMol pro ml Liquor an. Der mittlere arterielle Blutdruck änderte sich dabei von 93±2,4 mm Hg auf 107±3,7 mmHg. Der Blutdruckanstieg konnte durch intraventrikuläre Gabe des Angiotensin II Rezeptorenblockers Saralasin rückgängig gemacht werden. Die intraventrikuläre Injektion von Cathepsin D hatte keinen Effekt auf den arteriellen Blutdruck, und die Angiotensin I Konzentration im Liquor blieb unterhalb des Meßbereiches des Radioimmunoassays. Wir schließen daraus, daß Gehirnrenin unter physiologischen Bedingungen in vivo Angiotensin I von endogenem Gehirnangiotensinogen abspaltet. Angiotensin I wird zu Angiotensin II umgewandelt und führt zum Blutdruckanstieg.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01477451
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  • 2
    Electronic Resource
    Electronic Resource
    (6-oxo-3-pyridazinyl)-benzimidazoles as potent angiotensin II receptor antagonists
    Amsterdam : Elsevier
    Bioorganic & Medicinal Chemistry Letters 4 (1994), S. 1297-1302 
    Details
    ISSN: 0960-894X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0960-894X(01)80348-6
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  • 3
    Electronic Resource
    Electronic Resource
    THE ISO-RENIN ANGIOTENSIN SYSTEMS IN EXTRARENAL TISSUE (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 3 (1976), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1976.tb00596.x
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  • 4
    Electronic Resource
    Electronic Resource
    Phonon wave-packet dynamics at semiconductor interfaces by molecular-dynamics simulation (2002)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 80 (2002), S. 2484-2486 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We directly observe phonon wave packets of well-defined frequency and polarization scattering at a coherent semiconductor interface using molecular-dynamics simulations. We find that in the low-frequency limit the transmission coefficients of both longitudinal and transverse acoustic phonons agree well with those predicted by the continuum-level based acoustic mismatch model. However, the transmission coefficients rapidly decrease close to the cutoff frequency, a result that can be understood within a simple one-dimensional discrete atomic-chain model. We also find that the transmission coefficient for transverse acoustic phonons depends strongly on the relative orientation of the polarization and the Si–Si bonds in the diamond lattice structure. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1465106
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  • 5
    Electronic Resource
    Electronic Resource
    Effects of angiotensin II and of an angiotensin II receptor antagonist on Simian virus 40-induced tumor growth in vivo (1980)
    Springer
    Cellular and molecular life sciences 36 (1980), S. 452-454 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effects of angiotensin II and of the competitive angiotensin II receptor antagonist saralasin on in vivo tumor growth were investigated in hamsters. Angiotensin II strongly inhibited tumor growth while saralasin stimulated it, though the high dose used had partial agonistic angiotensin II-like actions. Lower doses of saralasin were without significant effect on tumor weights.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01975143
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of beta-adrenoceptor blockade on the cardiovascular and hyperglycaemic actions of diazoxide (1978)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 303 (1978), S. 15-20 
    Details
    ISSN: 1432-1912
    Keywords: Diazoxide ; Propranolol ; Tachycardia ; Hypotension ; Hyperglycaemia ; Sympathetic reflex activation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In unanaesthetized rabbits, diazoxide was injected i.v. in doses of 6.25, 12.5, and 25.0 mg/kg. A dose-dependent fall in blood pressure occurred, while heart rate rose to nearly maximum levels already with the lowest dose. After the medium and the high dose, blood glucose concentration increased continuously within the observation period of 2 h, and plasma concentration of angiotensin II was about 10-fold normal after the same time. Propranolol in doses of 0.67, 2.0, and 6.0 mg/kg, given i.v. 15 min before diazoxide (12.5 mg/kg), had no effect on the hypotensive action of the latter, but inhibited the increase both in heart rate and in blood pressure. The initial rise in heart rate was partly inhibited by 2 mg/kg propranolol, but no further inhibition was obtained by the dose of 6 mg/kg. Blood glucose increase was abolished by 2 mg/kg and markedly suppressed by 6 mg/kg propranolol. Beta-adrenoceptor blockade also reduced the elevated plasma concentration of angiotensin II. It is concluded that the rise in heart rate induced by diazoxide is caused not only by sympathetic stimulation, but also by a direct action on the heart. Similarly, the increase in plasma angiotensin II concentration is in part induced by beta-adrenoceptor stimulation and in addition by a direct renal mechanism. On the other hand, the hyperglycaemic effect seems to depend predominantly upon the stimulation of beta-adrenoceptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00496181
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  • 7
    Electronic Resource
    Electronic Resource
    Involvement of ATP-sensitive potassium channels in preconditioning protection (1994)
    Springer
    Basic research in cardiology 89 (1994), S. 563-576 
    Details
    ISSN: 1435-1803
    Keywords: Preconditioning ; stunning ; infarct size ; ATP-sensitive potassium channels ; glibenclamide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Single or multiple brief periods of ischemia (preconditioning, PC) have been shown to protect the myocardium from infarction during a subsequent more prolonged ischemic insult. To test the hypothesis that opening of ATP-sensitive potassium channels (KATP) is involved in this mechanism, either bimakalim, a KATP channel opener, or glibenclamide, a KATP channel blocker, were administered to mimic or to block preconditioning protection in barbital-anesthetized pigs. PC was elicited by a single period of 10 min left anterior descending coronary artery (LADCA) occlusion followed by 15 min of reperfusion before the LADCA was reoccluded for 60 min. Instead of PC, bimakalim infusion was started 15 min before the 60 min LADCA occlusion (TCO) and stopped with the onset of ischemia. Glibenclamide was administered either for 10 min prior to the PC protocol, before bimakakim infusion, or before TCO. Regional wall function was quantified with ultrasonic crystals aligned to measure wall thickening (%ΔWT). At the end of the protocol, infarct size was determined by incubating myocardium with p-nitrobluetetrazolium. In seven preconditioned pigs, infarct size was 9.9±5.1% of the risk region compared with 65.9±6.0% in the seven control pigs subjected to 60 min of ischemia only (p〈0.001). In seven pigs treated with bimakalim, infarct size was reduced to 35.3±6.6 (p〈0.05 vs. controls). Blocking ATP-sensitive potassium channels with glibenclamide prior to PC abolished its protective effect (infarct size, 62.2±4.5%;p〈0.001 vs. PC alone). Glibenclamide also antagonized the protective effect of bimakalim (infarct size, 55.2±4.0%), but did not affect infarct size, when solely administered prior to the prolonged ischemic period (62.2±4.3%). We conclude that in swine myocardium KATP channels are involved in the protective effect of ischemic preconditioning, since glibenclamide completely abolished the protective effect of preconditioning, while bimakalim could — at least in part — mimic it.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00794956
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  • 8
    Electronic Resource
    Electronic Resource
    Improvement of the homogeneity of the barley variety balder (1956)
    Springer
    Euphytica 5 (1956), S. 281-288 
    Details
    ISSN: 1573-5060
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary For the improvement of the purity of the Swedish barley variety Balder, a selection within this variety was started at the Plant Breeding Station of the “Centraal Bureau” at Hoofddorp in 1949. During the period 1950–1954 it appeared that a large number of types occurred which differed more or less distinctly from each other. The differences concerned inclination and colour of the leaves, length of straw, date of heading, stiffness of straw, length and inclination of the ear, earliness, yield capacity, grain- and malting quality. Of about 5,000 lines (progenies of selected ears) of 1950, only one, Balder 50.4 was chosen ultimately in 1954. Already in 1954 the breeder's seed of Balder was obtained by multiplication of selection 50.4. The purpose of the selection, described in this paper, viz. to give the barley variety Balder a sufficient approximation of a pure line, can be considered as being achieved. Certainly there is no indication that a decrease in yield capacity and malting quality occurred. Moreover, in comparison with the original variety Balder, selection 50.4 has distinctly stiffer and somewhat shorter straw, and a little earlier maturity. The attitude of the ear approximates more that of the erectum-type.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00038850
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