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  • 1
    Electronic Resource
    Electronic Resource
    Glycine: a new anti-inflammatory immunonutrient (1999)
    Springer
    Cellular and molecular life sciences 56 (1999), S. 843-856 
    Details
    ISSN: 1420-9071
    Keywords: Key words. Glycine; immunoregulation; anti-inflammatory; glycine receptor.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. The mechanism of the immunosuppressive effects of glycine and its pathophysiological applications are discussed in this review. Glycine has been well characterized in spinal cord as an inhibitory neurotransmitter which activates a glycine-gated chloride channel (GlyR) expressed in postsynaptic membranes. Activation of the channel allows the influx of chloride, preventing depolarization of the plasma membrane and the potentiation of excitatory signals along the axon. Glycine has recently been shown to have similar inhibitory effects on several white blood cells, including hepatic and alveolar macrophages, neutrophils, and lymphocytes. Pharmacological analysis using a GlyR antagonist strychnine, chloride-free buffer, and radiolabeled chloride has provided convincing evidence to support the hypothesis that many white blood cells contain a glycine-gated chloride channel with properties similar to the spinal cord GlyR. Molecular analysis using reverse transcription-polymerase chain reaction and Western blotting has identified the mRNA and protein for the β subunit of the GlyR in total RNA and purified membrane protein from rat Kupffer cells. Dietary glycine is protective in rat models against endotoxemia, liver ischemia-reperfusion, and liver transplantation, most likely by inactivating the Kupffer cell via this newly identified glycine-gated chloride channel. Glycine also prevents the growth of B16 melanomas cell in vivo. Moreover, dietary glycine is protective in the kidney against cyclosporin A toxicity and ischemia-reperfusion injury. Glycine may be useful clinically for the treatment of sepsis, adult respiratory distress syndrome, arthritis, and other diseases with an inflammatory component.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000180050030
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  • 2
    Electronic Resource
    Electronic Resource
    Endovaskuläre Therapie einer poplitealen arteriovenösen Fistel (1998)
    Springer
    Gefässchirurgie 3 (1998), S. 30-33 
    Details
    ISSN: 1434-3932
    Keywords: Schlüsselwörter Popliteale a.v.-Fistel ; Endovaskuläre Chirurgie ; Stentprothese ; Key words Popliteal a.v. fistula ; Endovascular surgery ; Stentgraft
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Background. Traditional open surgical management of popliteal arterio-venous fistula is both technically difficult and troublesome. Endovascular exclusion by transluminally placed stented grafts is a potentially less invasive new therapeutic option. Case report. A large popliteal arterio-venous fistula was diagnosed in a 26-year-old football player 5 years after a traumatic knee-joint injury with open repair of the ruptured anterior cruciale ligament. From the clinical aspect, a significant increase in leg volume and an enlargement of heart size were noticed. Therapy. After vascular surgeons and radiologists had established an interdisciplinary consensus, the endovascular approach was indicated. A Palmaz stent-anchored PTFE graft was percutaneously implanted via the femoral anterograde sheath access. A second endograft was implanted after 6 months to hemostatically exclude a persistent fistula. After 12-month follow-up, the stentgraft was still patent, and the patient was well and alive without any sign of leckage. Conclusion. The endoluminal implantation of stented grafts is a new therapeutic option in the management of chronic popliteal arterio-venous fistula.
    Notes: Zusammenfassung Hintergrund: Die konventionelle gefäßchirur-gische Therapie poplitealer arteriovenöser (a.v.-) Fisteln ist technisch aufwendig und komplikationsträchtig. Die endovaskuläre Therapie mit einer transluminal eingebrachten Stentprothese stellt eine möglicherweise weniger invasive neue therapeutische Option dar. Kasuistik: Bei einem 26jährigen Fußballspieler wurde 5 Jahre nach Kniegelenktrauma und operativer Versorgung eines vorderen Kreuzbrandrisses eine große a.v.-Fistel zwischen A. und V. poplitea diagnostiziert. Klinisch bestand eine deutliche Umfangszunahme des betroffenen Beins und eine Vergrößerung des Herzens. Therapie: Von gefäßchirurgischer und radiologischer Seite wurde gemeinsam die Indikation zur endovaskulären Therapie gestellt. Ein Palmaz-Stent wurde in einer PTFE-Prothese fixiert und über eine perkutan gelegt Schleuse über die A. femoralis antegrad eingebracht. Aufgrund einer Fistelpersistenz wurde nach 6 Monaten ein zweiter „covered Stent“ implantiert und die a.v.-Fistel suffizient abgedichtet. Nach weiteren 12 Monaten ist der Stentgraft frei durchgängig und der Patient weiterhin beschwerdefrei ohne Anhalt für eine weiter bestehende Fistel. Schlußfolgerung: Die endovaskuläre Implantation einer Stentprothese stellt eine therapeutische Alternative in der Behandlung chronischer pop-litealer a.v.-Fisteln dar.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00010493
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    Paper (German National Licenses)
    Fulltext
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