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  • 1
    Electronic Resource
    Electronic Resource
    The Potential of Using the Natural Rhythmicity of Cell Proliferation in Improving Cancer Chemotherapy in Rodents (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 618 (1991), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1991.tb27246.x
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  • 2
    Electronic Resource
    Electronic Resource
    Daily Circadian Rhythm in Rats to D -Amphetamine Sulphate: Effect of Blinding and Continuous Illumination on the Rhythm (1968)
    [s.l.] : Nature Publishing Group
    Nature 219 (1968), S. 621-622 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Adult Sprague-Dawley rats averaging 280 g were used. Before every experiment animals were kept in rigidly standardized environmental conditions12?14. The method of recording motor activity of the colony (Fig. 1) using a microphone has been published15. The data shown in Figs. 1 and 2 represent ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/219621a0
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  • 3
    Electronic Resource
    Electronic Resource
    Circadian variation in cell division of the mouse alimentary tract, bone marrow and corneal epithelium (1978)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 191 (1978), S. 479-486 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Circadian rhythms in DNA synthesis are described for the tongue epithelium, five different regions of the alimentary canal (gut) -esophagus, stomach, duodenum, jejunum and rectum- and bone marrow in a group of BDF1 male mice. A circadian rhythm is also described for the mitotic index in the corneal epithelium in the same mice. The data document for the first time in the same animals the dramatic variation in cell division encountered from one region of the gut to another. This variation is seen in the amplitudes of the rhythms as well as in the over-all 24-hour means. On the contrary, the phasings of the rhythms in the different regions of the gut are remarkably similar. In this study, where the mice were standardized to 12 hours of light (0600-1800) alternating with 12 hours of darkness, the peak of the DNA-synthesis rhythm occurred around the time of transition from dark to light, and the trough around the time of transition from light to dark. The implications of these findings, and those of others, to the study of cell kinetics and to cancer chemotherapy are discussed.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091910407
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  • 4
    Electronic Resource
    Electronic Resource
    Circadian variation of epidermal growth factor receptor in mouse liver (1989)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 224 (1989), S. 459-465 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The liver undergoes a biochemical and morphological circadian transformation. In this paper, we document circadian variation in the binding parameters of the hepatic epidermal growth factor receptor (EGFR). Liver membranes were prepared from ad libitum fed or fasted male CD2F1 mice killed at different circadian phases at 4 h intervals. Bmax (maximum binding) and Kd (dissociation constant) varied in a rhythmic fashion. The range of change for Bmax along the 24 h time scale was 423%. For Kd, it was 162%. Both peaked late in the dark span, and decreased late in the light span. Fasting and EGF treatment reduced Bmax and the amplitude of circadian variation.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092240402
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  • 5
    Electronic Resource
    Electronic Resource
    A circadian susceptibility rhythm in rats to pentobarbital sodiumSupported in part by U. S. Public Health grant 4659. (1968)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 160 (1968), S. 741-749 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: A colony of adult rats was maintained on a standardized regimen with artifical photoperiods extending from 0600 to 1800 alternating with 12 hours of darkness. Every hour during a 24-hour period separate subgroups of rats were injected with 35 mg/kg of pentobarbital sodium, and the duration of time each animal remained under anesthesia was recorded.The rats remained anesthetized for longer periods of time between the hours of 1600 and 2200 than at other times of the day; this indicates that the response to the drug is dependent on he circadian phase system of the animal. When the results were plotted along the 24-hour time scale, the difference between the crest and trough of the curve was about 100%.A second colony of rats was maintained in a similar fashion except that the animals were subjected to continuous illumination. The rhythm of their susceptibility to pentobarbital sodium persisted for at least four weeks in a form highly modified from the animals synchronized to a light-dark cycle.In a third colony of animals, the rhythm still was present four months after they had been blinded; but it was modified and different from either the light-dark synchronized animals or from rats subjected to continuous illumination.The importance of recognizing the time structure of the living organism is discussed.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091600409
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  • 6
    Electronic Resource
    Electronic Resource
    Daily rhythmic variations in blood coagulation times in ratsThis work was supported by Research grant no 4659 from U.S.P.H.S., N.I.H. (1967)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 157 (1967), S. 657-665 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: With all other environmental factors rigidly standardized, normal Sprague-Dawley rats were maintained under the following schedules: (1) 12 hours of artificial light 0600 to 1800 alternating with 12 hours of darkness-LD; (2) reversal of the first-DL; (3) constant darkness-DD, and (4) constant illumination-LL.After the animals had been under a specific lighting regimen for at least three weeks, blood coagulation times were determined on separate groups of 8 to 16 animals at bi-hourly intervals during a 24-hour period. Significant daily fluctuations or rhythms in coagulation times under all lighting conditions were found by plotting each of the bi-hourly mean values as a function of time. The temporal phasing of all rhythms in LD, DL, LL and DD were similar. The major changes found in the different lighting schedules involved overall magnitude, e.g., the overall 24-hour mean coagulation time for rats maintained in LL was 21% greater than for rats maintained in DD. Although total adrenalectomy or adrenal medullectomy did not abolish the characteristic LD rhythm, there was about a 100% decrease in the mean 24-hour coagulation time of LD adrenalectomized animals when compared to normal LD animals. No significant decrease was seen in adrenal demedullectomized animals when similarly compared with normal LD animals.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091570411
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  • 7
    Electronic Resource
    Electronic Resource
    Daily variation in 5-hydroxytryptamine in rat spleen and the effect of stimuli on the rhythmThis work was supported, in part, by Public Health Senrice grants AM12389 and NS-08929 and by NSF B82530R. (1972)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 173 (1972), S. 257-263 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Fluorometric measurements were made of 5-hydroxytryptamine levels in spleens obtained from separate subgroups of adult male rats killed at two-hourly intervals over four separate 24-hour time spans. For three weeks prior to obtaining tissue, all rats were standardized carefully and were subjected to 12 hours of light (0600-1800) followed by 12 hours of darkness. Analyses showed in each study very significant fluctuation over the 24-hour time scale; the range of change over this period was as great as 131%. The phasing of the rhythms, in spite of the rigid environmental synchronization, was not similar in any of the four studies. Possible explanations for this unexpected desynchronization are discussed. Spleen weights also fluctuated with a significant 24-hour circadian frequency.In addition, the rhythm characterizing this amine was described in female rats as well as the effect of different stimuli on the same rhythm. These stimuli were ether, immobilization and a ‘novelty’ situation; and all three significantly increased the levels of 5-HT in spleen when the overall 24-hour mean values of each experimental group were compared with controls. However, in all cases there were discrete time points when significant differences in 5-HT levels could not be obtained with any of the stimuli. This study demonstrates that the effect of the stimuli used depends on the phase of the rat's circadian system during which it was applied. The necessity of considering the natural rhythmic fluctuation in any investigation evaluating this biogenic amine in spleen is demonstrated.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091730302
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  • 8
    Electronic Resource
    Electronic Resource
    Ciradian rhythm in DNA synthesis in mouse thymus: Effect of altered lighting regimens, restricted feeding and presence of Ehrlich ascites tumor (1976)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 184 (1976), S. 275-284 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: A circadian rhythm in the incorporation of tritiated thymidine into DNA of the mouse thymus has been described. This same rhythm in animals bearing an 8-day Ehrlich ascites tumor (EAT) was altered in its phasing, wave-form and over-all 24-hour mean; the most striking alteration seen in four out of five studies was a reduction in the over-all DNA synthesis rate in tumor-bearing animals.Mice subjected to an altered light-dark cycle did not show a complete phase shift in their thymus DNA rhythm within two weeks, but during this time the rhythm in the mitotic index of their corneal epithelium completely phase shifted; the presence of the tumor had no effect on this latter rhythm. In mice subjected to a daily 4-hour restricted feeding schedule, the rhythm in DNA synthesis in the thymus became synchronized in that the peak occurred toward the end of the 4-hour restricted feeding span in both tumor and non-tumor-bearing animals. The rhythm in the mitotic index in the cornea was not phase shifted or altered by the restricted meal timing.The DNA synthesis rhythm in the normal thymus demonstrated a phasing similar to (1) the rhythm in the length of survival time in untreated mice challenged with EAT and (2) the rhythm in DNA synthesis in the normal spleen.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091840303
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  • 9
    Electronic Resource
    Electronic Resource
    Circadian influence on the frequency of labeled mitoses method in the stratified squamous epithelium of the mouse esophagus and tongue (1976)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 184 (1976), S. 265-273 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The frequency of labeled mitoses method (FLM) was used to study the cell kinetics in the stratified squamous epithelium of the mouse esophagus and tongue. FLMs were generated by injecting tritiated thymidine (TdR) at two different phases of the mouse circadian system: TdR was injected into one group of mice at 0900 and into a different, second group of mice at 2100. Three variables were monitored for each group; (1) the FLM, (2) the mitotic index and (3) the grain count over the labeled mitotic figures. In both the esophagus and the tongue there was a circadian rhythm in the mitotic index with the peak occurring during the first half of the diurnal phase and the trough occurring during the first half of the nocturnal phase. The FLM curves from each group revealed the following data: TextTransit time in G2+1/2M (TG2+1/2M)Transit time in S phase (TS)hourshoursEsophagus  -  TdR at 09002.55.3Esophagus  -  TdR at 21004.53.5Tongue  -  TdR at 09004.25.1Tongue  -  TdR at 21004.25.5Second waves of labeled mitoses were seen in the esophagus and tongue when TdR was injected at 0900. No second wave of labeled mitoses occurred in either the esophagus or the tongue when TdR was injected at 2100. For the esophagus the grain counts of the labeled mitotic figures in each group indicated that the rate of DNA synthesis was greater during late S phase, whether the TdR was injected at 0900 or 2100. During most of the S phase the rate of DNA synthesis was significantly greater in the TdR at 2100 group, which is the time of the circadian system when the esophagus demonstrated a relatively short Ts. In the epithelium of the tongue there were a few statistical differences in the rate of DNA synthesis between the groups and during the duration of the S phase within either group, but these data were difficult to interpret.The data demonstrate the influence of the circadian system in cell kinetic work and in the interpretation of data obtained with the FLM in renewing populations of cells which are not totally asynchronous.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091840302
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  • 10
    Electronic Resource
    Electronic Resource
    The persistence of a circadian rhythm in histamine response in guinea pigs maintained under continuous illumination (1973)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 175 (1973), S. 1-6 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Adult guinea pigs were carefully standardized for at least seven days prior to each experiment; this included an artificial light-dark cycle with light extending from 0600 to 1800. On three experimental days, eight animals were injected subcutaneously with 300 μg of histamine at six-hour intervals over a 24-hour period; each animal received four injections during one day. The size of the erythema produced each time was measured. In all three experiments a prominent group rhythm was demonstrated with maximum response occurring during the dark phase; minimum response always occurred during the latter part of the light phase. Such results indicate a strong synchronization among the animals of the group.Two additional, similar studies were performed on animals standardized in one case for 21 days and in the second for 35 days under continuous illumination. The group rhythms of histamine response under these conditions, when compared to the light-dark adapted group rhythm, were greatly modified in phasing and profile. The circadian rhythm in response to histamine persisted in each individual animal. The change in the phasing and profile of the group rhythm was due to a partial desynchronization among the individual animals subjected to continuous illumination.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091750102
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