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  • 1
    Electronic Resource
    Electronic Resource
    Guinea Pig Striatum as a Model of Human Dopamine Deamination: The Role of Monoamine Oxidase Isozyme Ratio, Localization, and Affinity for Substrate in Synaptic Dopamine Metabolism (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 45 (1985), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The kinetic properties of type A and type B monoamine oxidase (MAO) were examined in guinea pig striatum, rat striatum, and autopsied human caudate nucleus using 3,4-dihydroxyphenylethylamine (dopamine, DA) as the substrate. MAO isozyme ratio in guinea pig striatum (28% type A/72% type B) was similar to that in human caudate nucleus (25% type A/75% type B) but different from that in rat striatum (76% type A/24% type B). Additional similarities between guinea pig striatum and human caudate nucleus were demonstrated for the affinity constants (Km) of each MAO isozyme toward DA. Endogenous concentrations of DA, 3-methoxytyramine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid were also measured in guinea pig and rat striatum following selective type A (clorgyline-treated) and type B (deprenyl-treated) MAO inhibition. In guinea pig, DA metabolism was equally but only partially affected by clorgyline or deprenyl alone. Combined treatment with clorgyline and deprenyl was required for maximal alterations in DA metabolism. By contrast, DA metabolism in rat striatum was extensively altered by clorgyline but unaffected by deprenyl alone. Finally, the deamination of DA in synaptosomes from guinea pig striatum was examined following selective MAO isozyme inhibition. Neither clorgyline nor deprenyl alone reduced synaptosomal DA deamination. However, clorgyline and deprenyl together reduced DA deamination by 94%. These results suggest that the isozyme localization and/or isozyme affinity for DA, rather than the absolute isozyme content, determines the relative importance of type A and type B MAO in synaptic DA deamination. Moreover, based on the enzyme kinetic properties of each MAO isozyme, guinea pig striatum may serve as a suitable model of human DA deamination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1985.tb04086.x
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  • 2
    Electronic Resource
    Electronic Resource
    Turner's Syndrome and vein of Galen aneurysm —A previously unreported association (1981)
    Springer
    Acta neuropathologica 55 (1981), S. 189-191 
    Details
    ISSN: 1432-0533
    Keywords: Cerebral arteriovenous malformations ; Turner's syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Vein of Galen aneurysm (VGA) is an uncommon cerebral arteriovenous malformation which has not previously been reported in Turner's Syndrome. We report a case and present neuropathologic and radiographic results. There are few prior reports of neuropathologic examination in Turner's Syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691317
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  • 3
    Electronic Resource
    Electronic Resource
    Ultrastructural pathology in emetine-induced myopathy (1988)
    Springer
    Acta neuropathologica 75 (1988), S. 577-582 
    Details
    ISSN: 1432-0533
    Keywords: Cytoplasmic bodies ; Emetine ; Myopathy ; Sarcomeric lesions ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Progressive myopathy developed in two women who consumed ipecac syrup containing emetine hydrochloride to induce vomiting as part of their anorexia nervosa. Muscle biopsy specimens were characterized by severe disruption of the sarcomeres. The ultrastructural spectrum extended from “Z-band streaming” to the formation of cytoplasmic bodies and also comprised abnormalities of the sarcotubular system, thus suggesting that muscle weakness may be related to both sarcomeric and sarcotubular lesions in this self-inflicted myopathy. It is tempting to suggest that muscle weakness may be correlated with or based on the pathology in sarcomeres and the sarcotubular system. As the myopathy is clinically reversible upon discontinuation of ipecac consumption the morphological findings should also be potentially reversible. Experimentally induced emetine myopathy may, thus, serve as a useful model to study morphological dynamics of sarcomeric lesions, which may be observed separately or simultaneously in a variety of spontaneously occurring human neuromuscular disorders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686202
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  • 4
    Electronic Resource
    Electronic Resource
    Granulomatous encephalitis in Whipple's disease (1969)
    Springer
    Acta neuropathologica 13 (1969), S. 1-11 
    Details
    ISSN: 1432-0533
    Keywords: Whipple's Disease ; Granulomatous Encephalitis ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Von 21 Fällen von Whipplescher Krankheit in der Sammlung des Armed Forces Institute of Pathology zeigten 4 Fälle neurologische Symptome mit besonders ausgeprägten Hirnläsionen. Lichtmikroskopisch bestanden die Herde aus knötchenförmigen Anhäufungen von Makrophagen, deren Cytoplasma mit Hämatoxylin-Eosin eine charakteristische schwachblaue und nach Durchführung der Perjodsäure-Schiff-Reaktion eine stark rote Färbung zeigte. Elektronenmikroskopisch fanden sich in den Hirnläsionen Bacillen, die morphologisch den im Darm beschriebenen glichen und die auch dieselben Degenerationserscheinungen aufwiesen. Die Perjodsäure-Schiff-Reaktion färbt Kapselmaterial und Zellwände,die auch nach Untergang der Bacillen noch nachweisbar sind. Diese Beobachtungen werden als weiterer Beweis für die infektiöse Ätiologie der Whippleschen Krankheit angeführt.
    Notes: Summary Among the 21 autopsied cases of Whipple's disease on file at the Armed Forces Institute of Pathology, 4 had neurological symptoms and prominent involvement of the central nervous system, By light microscopy the lesions were composed of nodular aggregates of macrophages having cytoplasm that stained a distinctive pale blue with hematoxylin-eosin and bright red with the periodic acid-Schiff technique. By electron microscopy the cerebral lesions revealed bacilli morphologically identical to and undergoing the same sequence of degenerative changes as those observed in the intestine. The periodic acid-Schiff reaction stains the walls and the capsular material that persists even after intact organisms disappear. These observations further support the infectious nature of Whipple's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686137
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  • 5
    Electronic Resource
    Electronic Resource
    Neurofibrillary tangles in patients with Down's syndrome: A light and electron microscopic study (1973)
    Springer
    Acta neuropathologica 23 (1973), S. 342-346 
    Details
    ISSN: 1432-0533
    Keywords: Down's Syndrome ; Alzheimer's Disease ; Neurofibrillary Tangles ; Twisted Tubules
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two older patients with Down's syndrome and widespread neurofibrillary tangles and senile plaques were studied by light and electron microscopy. The ultrastructural demonstration of twisted tubules verified the assumption that the tangles encountered in these patients were Alzheimer's neurofibrillary tangles. Despite the morphological evidence of Alzheimer's disease, neither of these patients were clinically demented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687465
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  • 6
    Electronic Resource
    Electronic Resource
    Fine structure of the Pick and Hirano bodies in a case of Pick's disease (1968)
    Springer
    Acta neuropathologica 11 (1968), S. 330-337 
    Details
    ISSN: 1432-0533
    Keywords: Pick's Disease ; Pick Bodies ; Hirano Bodies ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Hirngewebe eines Falles von Pickscher Krankheit wurde licht-und elektronenmikroskopisch untersucht. Intraneuronale argentophile Picksche Körper wurden am zahlreichsten in den Pyramidenzellen des Hippocampus gefunden. Elektronenoptisch bestanden die Einschlußkörper aus einer Zusammenballung von körnigen Gebilden, die in einem unregelmäßigen Netz von vermehrten Neurofilamenten verstreut lagen. Viele eosinophile Hiranosche Körper fanden sich in nächster Nachbarschaft von Nervenzellen. Diese Körper bestanden aus verflochtenen Schichten von geperlten oder glatten Filamenten. Die mögliche Lokalisation der Hiranoschen Körper innerhalb von degenerierenden Axonendigungen wird diskutiert.
    Notes: Summary Brain tissue from an autopsied case of Pick's disease was studied by light and electron microscopy. Intraneuronal argentophilic Pick bodies were most numerous in the pyramidal cells of the hippocampus. By electron microscopy, these inclusions consisted of a conglomeration of granules enmeshed in an irregular network of proliferated neurofilaments. There were also multiple eosinophilic juxtaneuronal structures (Hirano bodies). By electron microscopy these consisted of interwoven sheaves of beaded and continuous filaments. The possible location of the Hirano bodies within degenerating axonal terminals is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686729
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  • 7
    Electronic Resource
    Electronic Resource
    Pick's disease with compound intraneuronal inclusion bodies (1970)
    Springer
    Acta neuropathologica 15 (1970), S. 293-297 
    Details
    ISSN: 1432-0533
    Keywords: Dementia ; Pick's Disease ; Pick Bodies ; Eosinophilic Cores
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Diese Mitteilung betrifft Befunde eines ungewöhnlichen Falles von Pickscher Krankheit, der durch unikale Einschlußkörperchen mit kleinem eosinophilen Zentrum innerhalb der hämatoxylinophilen Pick bodies (Silberkugeln) gekennzeichnet war. Diese Gebilde werden mit anderen Einschlüssen verglichen, die man bei der Pickschen Krankheit und bei Erkrankungen des motorischen Neurons findet.
    Notes: Summary This report presents findings from an unusual case of Pick's disease that was characterized by unique compound inclusion bodies consisting of a small eosinophilic core within the hematoxylinophilic Pick bodies. These structures are compared to other inclusions observed in Pick's disease and motor neuron disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684727
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  • 8
    Electronic Resource
    Electronic Resource
    Ultrastructure of Hirano bodies (1972)
    Springer
    Acta neuropathologica 21 (1972), S. 50-60 
    Details
    ISSN: 1432-0533
    Keywords: Hirano Bodies ; Rod-Like Structures ; Inclusions ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary By light microscopy, Hirano bodies are fusiform or spheroidal eosinophilic bodies, that are commonly observed in the hippocampi of the elderly and are especially numerous in patients with various dementias or degenerative diseases. Rarely, they have been demonstrated in other locations and even in animals. Ultrastructurally, the Hirano bodies are complex pleomorphic aggregates of intraneuronal fibrillary material found predominantly in the processes but occasionally in the perikarya. The Hirano bodies are assembled from multiple subunits, but occasionally in the perikarya. The Hirano bodies are assembled from multiple subunits, each consisting of two overlapping or intersecting expanses of parallel filaments. Depending on the plane of section and orientation, the subunit may appear as a lattice-work array of intersecting filaments, a row of regularly spaced punctate densities closely applied to a filament, or a broader feathery fibril. The subunits appear to be derived from the reorganization or precipitation of randomly dispersed finely filamentous material. Because of the diverse circumstance under which they are found, Hirano bodies are regarded as a non-specific manifestation of neuronal degeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687999
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  • 9
    Electronic Resource
    Electronic Resource
    Neurofibroma with aberrant tactile corpuscles (1974)
    Springer
    Acta neuropathologica 28 (1974), S. 161-165 
    Details
    ISSN: 1432-0533
    Keywords: Neurofibroma ; Pacinian neurofibroma ; Pacinian Corpuscles ; Meissner's Corpuscles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This report describes an unusual plexiform neurofibroma from a child with von Recklinghausen's disease that was characterized by the presence of numerous aberrant tactile corpuscles in both the original and recurrent tumor. The individual corpuscles appeared to be composed of combination of a Pacinian exterior and a meissnerian interior. This neoplasm is discussed in relation to previous reports of Pacinian neurofibromas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00710325
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  • 10
    Electronic Resource
    Electronic Resource
    “High spinal” dysrhaphism (1987)
    Springer
    Acta neurochirurgica 84 (1987), S. 136-139 
    Details
    ISSN: 0942-0940
    Keywords: Cervical vertebrae ; meningocele ; myelography ; spinal diseases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary “High spinal” (cervical and upper thoracic) dysrhaphism usually involves either a meningocele or a dermal sinus tract. These high spinal lesions can have a complex intradural anatomy at the level of the lesion (as this case reports) and are associated with an increased incidence of lower spinal occult dysrhaphic anomalies. It is therefore recommended that patients with “high spinal” dysrhaphism undergo radiological evaluation of the entire spine to identify those patients with intradural anomalies, define the anatomy for surgery, and investigate the lower spine for associated occult anomalies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01418839
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