ISSN:
1432-1335
Keywords:
Keywords Lung adenocarcinoma
;
NNK
;
Beta-adrenergic modulation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Objective: Lung cancer is the leading cause of cancer death in industrialized countries. Pulmonary adenocarcinoma (PAC) is the most common histologic type of lung cancer, and it is reproducibly induced by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in laboratory rodents. We have recently shown that the growth of cell lines derived from human PACs is controlled by β-adrenergic receptors, and that NNK is a high affinity agonist for this receptor family. Design: In the current study, we have tested the relevance of these in in vitro findings for in vivo NNK-induced lung tumorigenesis, using a well-established hamster model of NNK-induced PAC. Results: Our experiments demonstrate a significant increase in NNK-induced PAC multiplicity in animals chronically exposed to the β-adrenergic agonist epinephrine or theophylline which causes intracellular accumulation of the β-adrenergic second messenger cAMP. On the other hand, our data show that administration of the β-adrenergic antagonist propranolol prior to each NNK injection significantly inhibited the development of PACs. Discussion: Our findings support the hypothesis that the development of tobacco-associated PAC may be modulated by β-adrenergic agents, and that the interaction of NNK with β-adrenergic receptors contributes to the genesis of this histologic lung cancer type.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/PL00008474
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