Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Material
Language
  • 1
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Organometallics 13 (1994), S. 1518-1520 
    ISSN: 1520-6041
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Anatomy and embryology 160 (1980), S. 39-52 
    ISSN: 1432-0568
    Keywords: Cerebellar afferents ; Mossy fibers ; Climbing fibers ; Brainstem ; Reptiles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Origins of afferents to the cerebellar cortex from the brainstem were explored in turtles by means of the horseradish peroxidase (HRP) technique. Following relatively large injections involving all cortical layers, HRP label was observed in neural perikarya of the following structures: 1) contralateral reticular formation just lateral and ventral to the hypoglossal nucleus; 2) a few cells in the central gray of the cervical spinal cord; 3) neurons scattered in the dorsolateral, ventromedial and descending vestibular nuclei, mainly ipsilaterally; 4) a few solitary cells in the mesencephalic and medulalry tegmentum; 5) the nucleus isthmi magnocellularis caudalis on the ipsilateral side; 6) a group of small cells in the isthmic tectum; 7) the ipsilateral nucleus of the optic tract; 8) a prominent group of small cells in the isthmic region just rostral to the vestibular complex ipsilaterally. Most of these cells were localized within the so called nuclei gustatorius secundarius,-lemnisci lateralis and-isthmi parvocellularis. This parvocellular isthmic complex (PIC) was the only region containing labelled cells when small injections restricted to the molecular layer were achieved. We interpret the PIC as a source of climbing fibers, possibly corresponding to the mammalian inferior olive which migrates from the alar plate to its' ventral destination during ontogenesis. Connecting axons were sometimes homogeneously stained which permitted the tracing of connecting pathways. Contorted axon branches stained by anterograde HRP transport were found concentrated in cerebellar and superior vestibular nuclei and sparsely distributed in other vestibular nuclei.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1432-1106
    Keywords: Key words Brain transplantation ; MIF ; MSF ; 6-OHDA ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Activated microglia play an important role in the rejection of intracerebral grafts and the degeneration of axotomized neurones. We studied the effect of macrophage migration stimulatory factor (MSF) or macrophage migration inhibitory factor (MIF) on allogeneic foetal mesencephalic dopaminergic grafts transplanted into the striatum of 6-hydroxydopamine-lesioned rats. Rotation testing revealed a significant compensation of lesion-induced motor asymmetry 3 weeks post-grafting in animals treated with MIF and vehicle-treated controls compared with pre-graft values (Student′s t-test, P≤0.005) and MSF-treated animals (ANOVA, post hoc Fisher PLSD test, P≤0.05). The MSF group showed no significant compensation. Graft recipients with MIF application (1452.06 ± 164.32 tyrosine hydroxylase-positive ventral mesencephalic cells) and controls (1753.21 ± 165.51 tyrosine hydroxylase-positive neurones) displayed good graft survival. Animals with MSF application showed a significant reduction of tyrosine hydroxylase-positive grafted cells (MSF 570.36 ± 209.49 cells) and graft volumes compared with the MIF and the control group (ANOVA, post hoc Fisher PLSD test, P≤0.05). The propotional area of microglia was significantly reduced in MIF animals compared with control animals (ANOVA, post hoc Fisher PLSD test, P≤0.001). Activated microglia and macrophages were reduced by half in the MIF-treated group compared with MSF animals and controls. We conclude that intrastriatal injections of MSF result in impaired function and survival of allogeneic ventral mesencephalon (VM) grafts 3 weeks after transplantation. MIF can reduce the number of microglia and macrophages in allogeneic foetal VM grafts. A reduction of microglia via MIF application did not enhance graft function and survival.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 64 (1986), S. 19-26 
    ISSN: 1432-1106
    Keywords: Cholinergic innervation ; Brain stem ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Efferent vestibular and cochlear neurons were identified in the rat's brain stem by retrograde labelling with True Blue (TB) or wheat germ agglutinin — horseradish peroxidase (WGA-HRP) injected into the utricle. Such cells were found at the same locations described in 1983 by White and Warr (ipsilateral superior olivary nucleus (LSO), bilateral latero-ventral nucleus of the trapezoid body (LTz) bilateral group E medial and lateral to the genu facialis) and, in addition, bilaterally in the caudal pontine reticular nucleus (CPR) at the level of the descending facial nerve. Cholinergic neurons were identified by counterstaining sections containing TB filled perikarya for (1) acetylcholinesterase (AChE) following pretreatment with diisopropylfluorophosphate (DFP) or (2) choline acetyltransferase (ChAT), by immunohistochemistry with highly specific monoclonal antibodies. Many, but not all, vestibular efferent cell bodies located in group E were shown to be cholinergic. These and other recently published data suggest that the efferent octavus system may consist of a number of chemically distinct cell groups.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 680 (1993), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 6 (1997), S. 0 
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract Irradiation with ultraviolet (UV) B light results in the formation of apoptotic keratinocyles called sunburn cells (SC). Although generation of SC appears to be one of the most characteristic features of UV-induced skin damage and has been a well-known phenomenon for a long time, the mechanisms involved are not quite clear. Recently, it was demonstrated that tumor necrosis factor α (TNFα) appears to be involved in the formation of SC since neutralization of TNFα both in vitro and in vivo reduced UVB-induced apoptosis of keratinocytes. Pentoxifylline is a methylxanthine derivative suppressing the release of TNFα. Therefore, we studied whether PTX is able to prevent the formation of SC. Addition of PTX to UVB-exposed HaCaT cells reduced DNA-fragmentation as examined by nick translation evaluated by floweytometry. To prove whether PTX also reduces UVB-induced apoptosis in vivo. BALB/c mice were exposed to UVB on their abdomens, skin biopsies performed 24 h later and SC counted. A single dose of 2000 J/m2 caused a significant induction of SC which were remarkably reduced when PTX was injected intraperitoneally 3 h before and 12 h after UVB exposure. In summary, the data demonstrate that PTX can reduce the formation of SC both in vitro and in vivo and thus further support that TNFα is involved in UVB-induced apoptosis of keratinocytes.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc
    Experimental dermatology 13 (2004), S. 0 
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The molecular pathways regulating ultraviolet (UV) radiation-induced apoptosis of melanocytes, a cell population crucially involved in the protection of epidermal keratinocytes against the harmful effects of UV light, are poorly characterized. We show that the α-melanocyte-stimulating hormone (α-MSH) blocks UVB-induced apoptosis of normal human melanocytes in vitro. The effect of α-MSH is not restricted to melanocytes but is also operative in cells that do not produce melanin, for example in human epidermal keratinocytes and in dermal fibroblasts. α-MSH not only delays but also protects melanocytes from UVB-induced cell death. The anti-apoptotic activity of α-MSH is not mediated by a filtering effect or induction of melanin synthesis. α-MSH also does not induce changes in the cell cycle distribution or expression of Bcl2, Bclx, CD95 (Fas/APO-1) and FasL. In contrast, α-MSH markedly reduces the formation of cyclobutane pyrimidine dimers induced by UVB radiation. Human dermal fibroblasts carrying a defective XPA gene are not protected from UVB-induced apoptosis by α-MSH. These results highlight a novel biological activity of α-MSH as well as novel regulatory pathways within the UV response of skin cells targeted by this neuropeptide.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 941 (1988), S. 11-18 
    ISSN: 0005-2736
    Keywords: Alamethicin ; Channel gating ; Circular dichroism ; Lipid vesicle ; Peptide-lipid interaction
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    BBA - Protein Structure 439 (1976), S. 261-273 
    ISSN: 0005-2795
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...