ISSN:
1522-9602
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Mathematics
Notes:
Abstract The effect of an applied electromagnetic field on drug diffusion in a one dimensional, three-layer drug-receptor model has been analyzed and expressed in terms of a normalized turnover rate parameter. The analysis reveals that an imposed harmonic time-varying electromagnetic field may enhance or retard the drug turnover rate depending on the diffusional pattern, the equivalent Michaelis constant, the maximum drug turnover rate of the intrinsic drug-receptor system, as well as the power density and frequency of the applied electromagnetic field. It is estimated that the power density in the order of magnitude of 1μW/cm2 at 100 MHz frequency range may be required to induce significant rate effects.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02463248
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