ISSN:
1432-0428
Keywords:
Diabetes mellitus
;
late complications
;
pulmonary function
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We have investigated the influence of diabetes mellitus including the presence of late complications on the pulmonary system. To check this relationship 31 Type 1 (insulin-dependent) diabetic patients (mean age 30.6±5.32 years, mean duration of diabetes 12.9±5.05 years) were admitted into the trial and compared with 18 control subjects. Pulmonary function tests were measured including spirometric parameters, diffusing capacity, specific diffusing capacity and dynamic compliance measured at 20 and 60 breaths per min. No disturbance of the spirometric parameters was observed in the diabetic patients. Diffusing capacity in the diabetic patients with complications was significantly lower than in both the diabetic patients without complications and the control group (81.2±16.2%, 104±13.7%, 99.3±2.8%; p〈0.001, p〈0.005 respectively). Specific diffusing capacity was significantly lower in the diabetic patients than in the control subjects (80.3±13.1% vs 89.4±12.9%; p〈0.05). In the group with late complications specific diffusing capacity was lower than in the group without complications (69.7±9.17%; 87.2±10.7%, respectively; p〈0.001). Dynamic compliance at 20 breaths per min in diabetic patients was 84.06±17.08% vs 95.2±11.59% in the control subjects (p〈0.05). It was particularly low in the group with late complications 80.6±13.2% and patients with metabolic poor control, 80.3±12.02% (both p〈0.005 vs the control group). Dynamic compliance at 60 breaths per min was 60.1±15.0% as compared to 83.2±13.3% in the control group (p〈0.001). We conclude that the disturbances of dynamic compliance may be due to the local mosaic abnormalities of lung elasticity, caused by the non-enzymatic glycation of protein. Disturbances in diffusion in diabetic patients confirm the presence of microangiopathy in pulmonary vessels.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00401373
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