ISSN:
0942-0940
Keywords:
Gliomas
;
gray matter
;
positron emission tomography (PET)
;
radiochemotherapy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Haemocirculatory and metabolic changes in seemingly normal brain tissue following radiochemotherapy including nimustine hydrochloride (ACNU) and tegafur (FT) were analyzed using oxygen-15 and fluorine-18 positron emission tomography (PET) in seven patients with gliomas. At an early stage (within one month) after radiochemotherapy, marginal increases in regional cerebral blood flow (rCBF) and cerebral blood volume (rCBV) were found contralateral to the tumour in gray matter which was apparently normal brain structure, as seen on computerized tomography (CT). The oxygen extraction fraction (rOEF) decreased significantly (p 〈 0.05 by a paired-t test) from that of the pretreatment study, due to surgical decompression and radiochemotherapy. At the late stage (three to thirty-one months with a mean of thirteen months), rCBF decreased significantly from the early stage study (p〈0.05); oxygen consumption (rCMRO2) fell in all cases significantly from the pretreatment study (p〈0.01) and from the early stage study (p〈0.05); consequently, rOEF remained unchanged at a level similar to the early stage study. Glucose consumption (rCMRGl) increased slightly as compared with the early stage study but failed to be restored to the level of the pretreatment study. Noteworthy was a coupling reduction of rCBF and rCMRO2—presumably, a late delayed effect of radiochemotherapy. These preliminary results indicate that with PET studies it may be possible to predict damage to normal brain tissue after radiochemotherapy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01402891
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