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  • 1
    ISSN: 1432-0509
    Keywords: Key words: Gastrointestinal edema—Edema cirrhosis—Colon edema—CT.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: To evaluate the computed tomographic (CT) features of colonic wall thickening in cirrhotic patients and to determine their prognostic value. Methods: We retrospectively reviewed 28 cirrhotic patients with colonic wall thickening (≥10 mm) on CT. Twenty-six of the 28 patients had hepatocellular carcinoma. The severity of hepatic dysfunction was determined by using the Child–Pugh classification. We analyzed the patterns of bowel wall thickening and degree of portal hypertension on CT and the survival periods after initial CT detection of colonic wall thickening. Results: The involved segment of the colon was diffusely thickened with either scalloped or nodular circumferential configuration. In all patients, the thickened colonic wall enhanced poorly. Although the ascending colon was involved in all patients, the transverse (n= 14) or descending (n= 5) colon was also simultaneously involved. Most patients exhibited an advanced stage of portal hypertension on CT. The median survival period of 25 patients who expired was 34 days, and 21 patients (84%) expired within 3 months. Conclusions: Colonic wall thickening on CT can be used as one of the indicators of poor prognosis in cirrhotic patients. Advanced liver cirrhosis with significantly severe dysfunction is the likely cause of mortality. Therefore, a less aggressive therapeutic approach is recommended if hepatocellular carcinoma is coexistent in these patients.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0509
    Keywords: Key words: Intestines, radiography—Small intestine, gastrointestinal examination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Background: To evaluate and optimize a modified small bowel follow-through examination (SBFT) by using an oral administration of a large amount (600 mL) of methylcellulose after taking a small amount of barium. Methods: Ninety-nine normal subjects underwent modified SBFT with an oral administration of 600 mL of 0.5% methylcellulose after taking 100 mL of 120% or 100, 150, or 200 mL of 70% w/v barium. The transradiancy and distensibility of the bowel and the transit time were compared with those of 39 other normal subjects who underwent conventional SBFT with 500 mL of 70% w/v barium. Results: Except for two subjects who developed diarrhea immediately after examination, no patients complained of acute symptoms, such as abdominal pain or vomiting. Modified SBFT was much superior to conventional series for obtaining good bowel transradiancy and rapid transit time (range = 37–49 min), but bowel distention was not significantly improved. The use of 150 mL of 70% w/v barium was better than the other three modified techniques for achieving good bowel transradiancy, rapid transit time, and less occurrence of flocculation. Conclusion: Modified SBFT is a simple method for easily improving the image quality in terms of bowel transradiancy and transit time.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    The journal of membrane biology 154 (1996), S. 251 -257 
    ISSN: 1432-1424
    Keywords: Key words: Trachea — K+ channels — Basolateral membrane — cAMP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract. To study K+ channels in the basolateral membrane of chloride-secreting epithelia, rat tracheal epithelial monolayers were cultured on permeable filters and mounted into an Ussing chamber system. The mucosal membrane was permeabilized with nystatin (180 μg/ml) in the symmetrical high K+ (145 mm) Ringer solution. During measurement of the macroscopic K+ conductance properties of the basolateral membrane under a transepithelial voltage clamp, we detected at least two types of K+ currents: one is an inwardly rectifying K+ current and the other is a slowly activating outwardly rectifying K+ current. The inwardly rectifying K+ current is inhibited by Ba2+. The slowly activating K+ current was potentiated by cAMP and inhibited by clofilium, phorbol 12-myristae 13-acetate (PMA) and lowering temperature. This is consistent with the biophysical characteristics of I SK channel. RT-PCR analysis revealed the presence of I SK cDNA in the rat trachea epithelia. Although 0.1 mm Ba2+ only had minimal affect on short-circuit current (I sc) induced by cAMP in intact epithelia, 0.1 mm clofilium strongly inhibited it. These results indicate that I SK might be important for maintaining cAMP-induced chloride secretion in the rat trachea epithelia.
    Type of Medium: Electronic Resource
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