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  • 1
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Asthma is an increasing health problem worldwide, but the long-term temporal pattern of clinical symptoms is not understood and predicting asthma episodes is not generally possible. We analyse the time series of peak expiratory flows, a standard measurement of airway function that has been ...
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In lung diseases such as asthma, expiratory flow becomes limited, airways can collapse and the vital exchange of gases is compromised. Here we model the inflation of collapsed regions of the lung during inspiration in terms of avalanches propagating through a bifurcating network of airways, and ...
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 368 (1994), S. 615-618 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] FIG. 1 a, The terminal airway resistance Rt as a function of inflation time for three different capsules on a single dog lung lobe. The measurements were carried out using a modification6 of the alveolar capsule oscillator technique5. Three small plastic capsules were glued to the surface of each ...
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-9686
    Keywords: Airway impedance ; Airway resistance ; Airway acoustics ; Airway wall properties ; Airway geometry ; Branching asymmetry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Indirect measures of airway diameter such as respiratory system input impedance (Z in) have been widely used to infer or quantify bronchoconstriction, or bronchodilation. One such measure, Z in above 100 Hz has been shown to be primarily influenced by airway geometry and airway walls but not by lung and chest wall tissues. We used a recently developed method based on a complex asymmetrically branched network of tubes with nonrigid walls to analyze Z in from 100 to 2,000 Hz in control and bronchoconstricted (histamine injection) dogs. The resulting estimates of airway diameters indicated that peripheral airways were constricted far more (≈30% of their control diameters) than central airways (i.e., 0% in the trachea). Separate measurements of changes in airway diameters were made in an excised dog lung using high resolution computed tomography. The observed changes in airway diameter between lung volumes of total lung capacity (TLC) and functional residual capacity (FRC) were quantitatively consistent with those obtained from Z indata in our control dogs at FRC. We conclude that this systems identification method can be used to estimate the distribution of airway diameters from Z in.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Annals of biomedical engineering 26 (1998), S. 230-241 
    ISSN: 1573-9686
    Keywords: Lung resistance ; Lung elastance ; Airway inhomogeneities ; Viscoelasticity ; Nonlinearity ; Confidence bound ; Sensitivity analysis ; Nonlinear models ; Lung: mechanics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract We present a combined theoretical and numerical procedure for sensitivity analyses of lung mechanics models that are nonlinear in both state variables and parameters. We apply the analyses to a recently proposed nonlinear lung model which incorporates a wide range of potential nonlinear identification conditions including nonlinear viscoelastic tissues, airway inhomogeneities via a parallel airway resistance distribution function, and a nonlinear block-structure paradigm. Additionally, we examine a system identification procedure which fits time- and frequency-domain data simultaneously. Model nonlinearities motivate sensitivity analyses involving numerical approximation of sensitivity coefficients. Examination of the normalized sensitivity coefficients provides direct insight on the relative importance of each model parameter, and hence the respective mechanism. More formal quantification of parameter uniqueness requires approximation of the paired and multidimensional parameter confidence regions. Combined with parameter estimation, we use the sensitivity analyses to justify tissue nonlinearities in modeling of lung mechanics for healthy and airway constricted conditions, and to justify both airway inhomogeneities and tissue nonlinearities during broncoconstriction. The tools in this paper are general and can be applied to a wide class of nonlinear models. © 1998 Biomedical Engineering Society. PAC98: 8745Hw, 8710+e
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-9686
    Keywords: Respiratory impedance ; Ventilator ; Real-time estimation ; Intensive care unit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Time-domain estimation has been invoked for tracking of respiratory mechanical properties using primarily a simple single-compartment model containing a series resistance (R rs) and elastance (E rs). However, owing to the viscoelastic properties of respiratory tissues,R rs andE rs exhibit frequency dependence below 2 Hz. The goal of this study was to investigate the bias and statistical accuracy of various time-domain approaches with respect to model properties, as well as the estimated impedance spectra. Particular emphasis was placed on establishing the tracking capability using a standard step ventilation. A simulation study compared continuous-timeversus discrete-time approaches for both the single-compartment and two-compartment models. Data were acquired in four healthy humans and two dogs before and after induced severe pulmonary edema while applying sinusoidal and standard ventilator forcing.R rs andE rs were estimated either by the standard Fast Fourier Transform (FFT) approach or by a time-domain least square estimation. Results show that the continuous-time model form produced the least bias and smallest parameter uncertainty for a single-compartment analysis and is quite amenable for reliable on-line tracking. The discrete-time approach exhibits large uncertainty and bias, particularly with increasing noise in the flow data. In humans, the time-domain approach produced smooth estimates ofR rs andE rs spectra, but they were statistically unreliable at the lower frequencies. In dogs, both the FFT and time-domain analysis produced reliable and stable estimates forR rs orE rs spectra for frequencies out to 2 Hz in all conditions. Nevertheless, obtaining stable on-line parameter estimates for the two-compartment viscoelastic models remained difficult. We conclude that time-domain analysis of respiratory mechanics should invoke a continuous-time model form.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Annals of biomedical engineering 26 (1998), S. 103-116 
    ISSN: 1573-9686
    Keywords: Memory length ; Nonlinearity ; Measurement noise ; Ventilatory wave form ; Stress relaxation ; Volterra kernel ; Lung ; Tissue viscoelasticity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract The goal of this study is to quantitatively investigate how the memory length, order of nonlinearity, type of input, and measurement noise can affect the identification of the Volterra kernels of a nonlinear viscoelastic system, and hence the inference on system structure. We explored these aspects with emphasis on nonlinear lung tissue mechanics around breathing frequencies, where the memory length issue can be critical and a ventilatory input is clinically demanded. We adopted and examined Korenberg's fast orthogonal algorithm since it is a least-squares technique that does not demand white Gaussian noise input and makes no presumptions on the kernel shape and system structure. We then propose a memory autosearch method, which incorporates Akaike's final production error criterion into Korenberg's fast orthogonal algorithm to identify the memory length simultaneously with the kernels. Finally, we designed a special ventilatory flow input and evaluated its potential for the kernel identification of the nonlinear systems requiring oscillatory forcing. We found that the long memory associated with soft tissue viscoelasticity may prohibit correct identification of the higher-order kernels of the lung. However, the key characteristics of the first-order kernel may be revealed through averaging over multiple experiments and estimations. © 1998 Biomedical Engineering Society. PAC98: 8745Bp, 8710+e, 8350Gd, 8380Lz
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1573-9686
    Keywords: Stress relaxation ; Long memory ; Fractals ; Wiener model ; Collagen fibers ; Elastin fibers ; Network
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Lung parenchyma is a soft biological material composed of many interacting elements such as the interstitial cells, extracellular collagen–elastin fiber network, and proteoglycan ground substance. The mechanical behavior of this delicate structure is complex showing several mild but distinct types of nonlinearities and a fractal-like long memory stress relaxation characterized by a power-law function. To characterize tissue nonlinearity in the presence of such long memory, we investigated the robustness and predictive ability of several nonlinear system identification techniques on stress–strain data obtained from lung tissue strips with various input wave forms. We found that in general, for a mildly nonlinear system with long memory, a nonparametric nonlinear system identification in the frequency domain is preferred over time-domain techniques. More importantly, if a suitable parametric nonlinear model is available that captures the long memory of the system with only a few parameters, high predictive ability with substantially increased robustness can be achieved. The results provide evidence that the first-order kernel of the stress–strain relationship is consistent with a fractal-type long memory stress relaxation and the nonlinearity can be described as a Wiener-type nonlinear structure for displacements mimicking tidal breathing. © 1999 Biomedical Engineering Society. PAC99: 8719Rr, 8710+e
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Annals of biomedical engineering 23 (1995), S. 672-681 
    ISSN: 1573-9686
    Keywords: Crosstalk ; Hammerstein model ; Wiener model ; Lung tissue mechanics ; Bronchoconstriction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract We present a simple index, extended harmonic distortion (k d ), to represent the degree of system nonlinearity under sparse pseudorandom noise inputs (SPRN). The frequencies in a SPRN waveform are neither harmonics nor sums or differences of the other component frequencies. Expressed by percentage, the k d is the square root of the ratio of output power at non-input frequencies to the total output power. We evoke three simple corrections to recover the true k d under imperfect SPRN inputs. Simulations on two block-structured nonlinear models (Wiener and Hammerstein) demonstrate the necessity and effectiveness of these corrections especially for the Wiener-type nonlinearity. By applying k d to pressure-flow data of dog lungs, we found that the nonlinear harmonic interactions from a lung arise primarily from its tissues most likely the processes governing the tissue stiffness. This nonlinearity, assessed from k d , is stronger at higher tidal volumes and enhanced (but to a lesser degree) during bronchoconstriction. We conclude that since the k d approach avoids the necessity for multiple-input measurements and lengthy data records, it may be useful for tracking the dynamic variations in nonlinearities of a physiological system.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Annals of biomedical engineering 26 (1998), S. 488-501 
    ISSN: 1573-9686
    Keywords: Least squares regression ; Analysis of variance ; Laguerre expansion ; Orthogonal algorithm ; Peripheral auditory system model ; Sensitivity analysis ; Kernel ; Nonlinear physiological system identification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Many techniques have been developed for the estimation of the Volterra/Wiener kernels of nonlinear systems, and have found extensive application in the study of various physiological systems. To date, however, we are not aware of methods for estimating the reliability of these kernels from single data records. In this study, we develop a formal analysis of variance for least-squares based nonlinear system identification algorithms. Expressions are developed for the variance of the estimated kernel coefficients and are used to place confidence bounds around both kernel estimates and output predictions. Specific bounds are developed for two such identification algorithms: Korenberg's fast orthogonal algorithm and the Laguerre expansion technique. Simulations, employing a model representative of the peripheral auditory system, are used to validate the theoretical derivations, and to explore their sensitivity to assumptions regarding the system and data. The simulations show excellent agreement between the variances of kernel coefficients and output predictions as estimated from the results of a single trial compared to the same quantities computed from an ensemble of 1000 Monte Carlo runs. These techniques were validated with white and nonwhite Gaussian inputs and with white Gaussian and nonwhite non-Gaussian measurement noise on the output, provided that the output noise source was independent of the test input.
    Type of Medium: Electronic Resource
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