Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Renal excretion of an angiotensin I converting enzyme inhibitor (SA-446) in dogs (1984)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 325 (1984), S. 356-359 
    Details
    ISSN: 1432-1912
    Keywords: Angiotensin converting enzyme inhibitor ; SA-446 ; Probenecid ; Renal clearance of SA-446 ; Organic anion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The renal excretory mechanism of an orally active inhibitor of angiotensin converting enzyme (SA-446) was examined in anesthetized dogs. Parenteral administration of this compound resulted in production of constant levels of about 2 mg/l in the plasma (PSA) and the urine concentration was 726±200 mg/l, a level significantly higher than that in the plasma. Renal clearance of SA-446 (CSA) was 2.24±0.34 ml/g·min and was significantly higher than GFR. The clearance ratio (CSA/GFR) of over 1.0 was indicative of a net tubular secretion. Administration of probenecid resulted in a significant rise in PSA and in a significant decrease in urinary excretion but with no change in the plasma protein binding ratio. CSA decreased significantly from 2.24±0.34 to 0.71±0.14 ml/g·min. The inhibotory action of SA-446 (0.02 mg/kg, i.v.) on the pressor response to angiotensin I disappeared at about 50 min, this action being maintained for about 2 h in the probenecid pretreated dog. Since probenecid is a competitive inhibitor of organic anion secretory transport, our results show the net tubular secretion of SA-446, via organic anion transport systems. Prolongation of the action of SA-446, as induced by probenecid may be due to the increase of plasma concentration, by the inhibition of tubular secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00504381
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    The effect of blood pressure on inner ear blood flow (1984)
    Springer
    European archives of oto-rhino-laryngology and head & neck 239 (1984), S. 197-203 
    Details
    ISSN: 1434-4726
    Keywords: Inner ear blood flow ; Blood pressure ; Angiotensin II
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We investigated the effects of blood pressure on the blood flow in the inner ear as compared with other organs in normotensive rats (NR), spontaneously hypertensive rats (SHR) and renal hypertensive rats (RHR). The cardiac output and the regional blood flow were measured by a radioactive microsphere technique in conscious rats. The haemodynamics of the inner ear and other organs and the effects of a converting-enzyme inhibitor (SA-446) on the regional blood flow were compared among NR, SHR, and RHR, the blood pressure being 107, 152, and 185 mm Hg, respectively. With the exception of the heart, the organ blood flow was lower in SHR than in NR in all organs, including the inner ear. It was also lower in RHR than in SHR. The blood pressure dropped after i.v. injection of SA-446, while the regional blood flow increased. The effect was strongest in RHR, followed by SHR and finally NR.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00464244
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...