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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of clinical monitoring and computing 13 (1997), S. 5-9 
    ISSN: 1573-2614
    Keywords: Monitoring ; carbon dioxide ; relative humidity ; Measurement techniques ; airway obstruction ; Ventilation ; apnea ; Equipment: airway ; hygrometer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Medicine
    Notes: Abstract Objective. The aim of this study was to detect cyclic changes in the relative humidity (RH) occurring with spontaneous respiration using a rapid-response hygrometer, and to evaluate its potential applicability as an apnea monitor in nonintubated subjects. Methods. Respiratory monitoring using a rapid-response hygrometer was performed in spontaneously breathing, nonintubated subjects. Changes in RH during spontaneous breathing were measured in adult volunteers, breathing room air and nonintubated infants who underwent cardiac catheterization under intravenous anesthesia. The detection of apnea by the hygrometer was assessed in the adult patients during the induction of anesthesia and those undergoing minor gynecologic surgery under epidural anesthesia. The hygrometric sensor was positioned in front of the nostril; a simultaneous recording of CO2 was obtained from nasal cannulas by a sidestream capnograph. Each waveform was collected and acquired by a PC-based computer, and data were analyzed off-line. Results. The hygrometer showed a rapid response to the cyclic changes in RH during spontaneous respiration and could identify respiratory phases of tachypnea as high as 60 breaths per minute in infants. RH rapidly increased to 80% with a plateau on expiration and decreased to 40% on inspiration. These phasic changes, consisting of three distinct phases, expiratory upstroke, plateau and inspiratory downslope, preceded the corresponding capnographic changes by nearly two seconds. Expiratory increase in RH appeared to be influenced by the respiratory flow rate as well as the response time of the equipment. As respiration was depressed due to airway obstruction, the magnitude of RH gradually decreased and then disappeared at the time of apnea. Conclusions. The hygrometer could detect cyclic changes in RH during spontaneous respiration. Apnea was immediately detected by the decreases in the magnitude of RH. The results demonstrate the potential usefulness of a rapid-response hygrometer for monitoring respiratory rate and early detection of apnea.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1438-8359
    Keywords: Inhalation anesthetics ; Artemia salina ; Motility ; Video monitoring ; Cooperativity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The swimming movement of artemia salina in the artificial sea water was measured by using the video camera system in the absence and presence of anesthetics, i.e. enflurane, halothane, and isoflurane. The movement of artemia looked random at a glance but the obtained distribution curve for the swimming speed was skewed toward the high speed side somewhat resembling a Maxwellian distribution curve seen in the statistics of ideal gases. When anesthetic were added, the distribution curve became sharpened and shifted to the low speed side, which is similar to a behavior of ideal gasses when they are cooled down. The mean swimming-speed was decreased eventually leading to an irreversible death with increasing the anesthetic dose. The activity was analyzed by using the hydrodynamic equation. The ED50, which is a dose that causes a 50% reduction in the activity, of all anesthetics used in this study was quite similar to the MAC values for human. It was also suggested that an interaction between anesthetics and artemia was highly cooperative since the larger Hill coefficients were obtained for all three anesthetics used. (Takasaki T, Tatara T, Suezaki Y, et al.: Effect of inhalation anesthetics on swimming activity of artemia salina. J Anesth 5: 287–293, 1991)
    Type of Medium: Electronic Resource
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