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  • 1
    Electronic Resource
    Electronic Resource
    Diet, bacteria and colonic cancer (1999)
    Bingley : Emerald
    Nutrition & food science 99 (1999), S. 187-193 
    Details
    ISSN: 0034-6659
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The links between diet, bacteria and colonic cancer are examined in this article. Studies suggest that high intakes of fat and protein are associated with elevated risk of colonic cancer whereas cereals, fruits and vegetables seem to be protective. A further aspect considered in relation to this type of cancer is metabolism by gut bacteria. Probiotics, prebiotics and synbiotics are presented as ways of stimulating the activities, certain gut flora and the use of "functional foods" is also discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/00346659910270945
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  • 2
    Electronic Resource
    Electronic Resource
    Phase II study of aziridinylbenzoquinone (AZQ) in patients with central nervous system malignancies: a Southwest Oncology Group study (1985)
    Springer
    Journal of neuro-oncology 3 (1985), S. 131-135 
    Details
    ISSN: 1573-7373
    Keywords: AZQ ; carbamic acid ; central nervous system malignancies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary AZQ, an alkylating agent with lipophilic characteristics allowing CNS penetration was studied in patients with primary CNS malignancies refractory to surgical and radiotherapeutic modalities. Responses were evaluated by three criteria: neurologic examination, performance status and CT scan of the brain. Improvement in all three parameters with stable or decreasing doses of decadron was required for a partial response. Thirty-six poor risk (prior chematherapy) patients with Grades III and IV astrocytomas were treated with 30 mg/m2. Three patients had a partial response (14, 17, 60 weeks duration). Two patients had mixed responses (worsening of one disease parameter with improvement in another), four had stable disease and one patient had improvement in neurologic parameters with a stable CT scan. Twenty-six patients had increasing disease. Fifteen good risk patients (no prior chemotherapy) with recurrent grades III and IV astrocytomas were treated at a dose of 40 mg/m2 intravenously every three weeks. There were no objective responses in this group of patients. Three patients with nonastrocytomas were treated and no responses observed. The drug was well tolerated. Myelosuppression in the form of leukopenia and thrombocytopenia was the major toxicity. Myelosuppression required dose reductions in eight patients and discontinuation of therapy due to repeated treatment delays in two patients. AZQ at doses of 30 and 40 mg/m2 given on an intermittent bolus schedule is inactive in patients with Grades III and IV recurrent astrocytoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02228889
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  • 3
    Electronic Resource
    Electronic Resource
    Phase II evaluation of echinomycin (NSC-526417) in patients with central nervous system malignancies (1993)
    Springer
    Journal of neuro-oncology 15 (1993), S. 181-184 
    Details
    ISSN: 1573-7373
    Keywords: echinomycin ; central nervous system malignancies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The objective of this trial was to determine the efficacy of echinomycin (1.2mg/m2) administered on a weekly times four schedule in the treatment of patients with recurrent or progressive central nervous malignancies despite adequate radiotherapy. Thirty-five patients were registered on study. The majority of patients (20) had glioblastoma multiforme. Ten had anaplastic astrocytoma. Eight patients had received prior nitrosoureas. SWOG performance status was 1 in 11 patients and 2 in 22. The median age was 51 years (25–75 years). One patient had a partial remission (3%:95% confidence interval: 1%–16%). Twenty two patients had progressive disease. The median survival was 5.9 months. Toxicity was primarily gastrointestinal with nausea and vomiting in 13 patients and nausea only in 11 patients. Hepatotoxicity occurred in 10 patients. Echinomycin given at this dose and schedule is not effective in treating patients with recurrent or progressive glioblastoma multiforme or anaplastic astrocytomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01053939
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  • 4
    Electronic Resource
    Electronic Resource
    Whole brain irradiation and intrathecal Methotrexate in the treatment of solid tumor leptomeningeal metastases — A Southwest Oncology Group study (1988)
    Springer
    Journal of neuro-oncology 6 (1988), S. 107-112 
    Details
    ISSN: 1573-7373
    Keywords: leptomeningeal carcinomatosis ; intrathecal methotrexate ; whole brain irradiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary From 1981 through 1985 the Southwest Oncology Group (SWOG) conducted a study evaluating the natural history and the effectiveness of standard therapy in those patients with leptomeningeal carcinomatosis from non-hematologic malignancies. Twenty-six patients were evaluated for the effectiveness of treatment; those who responded to therapy by one month exhibited a median additional survival of 5.7 months and those who were not responders at one month exhibited a median additional survival of 1.8 months. We were unable to identify pre-treatment clinical characteristics which would predict for a favorable response to therapy. Aggressive treatment in some patients may be indicated, as those patients who respond to treatment may have a survival benefit. The overall prognosis in this patient group remains exceedingly poor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02327385
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  • 5
    Electronic Resource
    Electronic Resource
    New agents in the treatment of primary brain tumors (1994)
    Springer
    Journal of neuro-oncology 20 (1994), S. 141-153 
    Details
    ISSN: 1573-7373
    Keywords: central nervous system tumors ; new agents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A review of single agent trials of cytotoxic agents in adults with high grade gliomas is presented. The rationale for testing these agents in patients with brain tumors was variable and is discussed. The criteria to evaluate responses were also variable ranging from subjective evaluation of clinical improvement with a stable radiographic assessment to the same objective response criteria utilized for solid tumors. Trials of agents specifically designed for brain tumors such as AZQ and spiromustine have been disappointing. There are encouraging results being seen in early trials of newer agents which await confirmation in larger trials but which hold promise for improving the disappointing results seen so far with chemotherapy in primary brain tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01052724
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  • 6
    Electronic Resource
    Electronic Resource
    Differential solubility of subcomponents of rat glomerular basement membrane (1984)
    Springer
    Bioscience reports 4 (1984), S. 319-326 
    Details
    ISSN: 1573-4935
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Marked differences were found in the electrophoretic profiles and amino-acid compositions of components prepared from rat glomerular basement membrane (GBM) by a number of different solubilization procedures. Treatment with reducing agent resulted in a simplified electrophoretic pattern which was characterized by the presence of a major collagenous component with a mol.wt, of 150 000. In contrast, detergent solubilized mainly lower-mol.-wt, material which had a more polar amino-acid composition. When both reagents were used together the majority of the basement-membrane material was soJubilized within 2 h and components with mol.wts, of 170 000 and 135 000 were predominant i n the pro-α region of the gel. Treatment for a further 16 h was required to solubilize higher-mol.-wt, material and to achieve maximum solubility of components in the pro-α region with mol.wts, of 185 000 and 150 000. These methods provide a means of separating subcomponents of rat GBM while avoiding the problems of degradation inherent in enzymatic procedures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01140495
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  • 7
    Electronic Resource
    Electronic Resource
    A Southwest Oncology Group phase II evaluation of fluderabine monophosphate in sarcoma (1994)
    Springer
    Investigational new drugs 12 (1994), S. 259-261 
    Details
    ISSN: 1573-0646
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00873969
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  • 8
    Electronic Resource
    Electronic Resource
    Evaluation of topotecan in patients with recurrent for metastatic squamous cell carcinoma of the head and neck (1996)
    Springer
    Investigational new drugs 14 (1996), S. 403-407 
    Details
    ISSN: 1573-0646
    Keywords: head and neck cancer ; topotecan ; topoisomerase-I inhibitor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Twenty-nine patients with persistent, recurrent and/or metastatic squamous cell carcinoma of the head and neck were treated daily for five days at three-week intervals with topotecan 1.5 mg/m2. Four patients received prior chemotherapy, 23 prior surgery and 29 prior radiation therapy. Of the 29 eligible patients, 8 patients were not evaluable for response and were assumed to be non-responders. Of the remaining 21 évaluable patients, there were zero responses (0%, 95% confidence interval [0,.12]). The most common toxicities were myelosuppression, dyspnea and malaise/fatigue/lethargy. Topotecan has limited activity in advanced head and neck cancer with this dose and schedule.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00180818
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  • 9
    Electronic Resource
    Electronic Resource
    Phase II trial of menogaril in metastatic adenocarcinoma of the prostate (1994)
    Springer
    Investigational new drugs 12 (1994), S. 67-70 
    Details
    ISSN: 1573-0646
    Keywords: prostate cancer ; menogaril ; phase II
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Menogaril, a semisynthetic anthracycline antibiotic, was administered to patients with metastatic adenocarcinoma of the prostate. Forty-five patients with measurable disease and 45 patients with evaluable disease received 150–200 mg/m2 over 1 hour every 28 days. There were three partial responses (PR) among 87 patients evaluable for response. Myelosuppression was dose limiting. There were two deaths related to leukepenia. Other toxicities included phlebitis, alopecia, nausea and vomiting. One patient developed acute nonlymphocytic leukemia. Menogaril at these doses and schedule is toxic and has no signficant antitumor activity in metastatic adenocarcinoma of the prostate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00873240
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  • 10
    Electronic Resource
    Electronic Resource
    Phase II trial of intravenous melphalan for metastatic colorectal carcinoma (1990)
    Springer
    Investigational new drugs 8 (1990), S. S87 
    Details
    ISSN: 1573-0646
    Keywords: melphalan ; colon cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Based on the high response rates seen among patients with colon cancer receiving high dose Melphalan with autologous marrow infusion, the Southwest Oncology Group conducted a Phase II trial of the compound at a conventional dose. The initial starting dose of 40 mg/m2 was reduced to 30 mg/m2 after severe myelotoxicity was encountered in the first five patients. Toxicity was primarily myeloid and was moderate to severe in most patients with one treatment related death. There were two complete and one partial response among 43 patients. Melphalan at 30 mg/m2 has little activity among patients with metastatic colorectal carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00171991
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