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  • 1
    Electronic Resource
    Electronic Resource
    Physiological Control of Immune Response and Inflammatory Tissue Damage by Hypoxia-Inducible Factors and Adenosine A2A Receptors* (2004)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 22 (2004), S. 657-682 
    Details
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Immune cell-mediated destruction of pathogens may result in excessive collateral damage to normal tissues, and the failure to control activated immune cells may cause immunopathologies. The search for physiological mechanisms that downregulate activated immune cells has revealed a critical role for extracellular adenosine and for immunosuppressive A2A adenosine receptors in protecting tissue from inflammatory damage. Tissue damage-associated deep hypoxia, hypoxia-inducible factors, and hypoxia-induced accumulation of adenosine may represent one of the most fundamental and immediate tissue-protecting mechanisms, with adenosine A2A receptors triggering "OFF" signals in activated immune cells. In these regulatory mechanisms, oxygen deprivation and extracellular adenosine accumulation serve as "reporters," while A2A adenosine receptors serve as "sensors" of excessive tissue damage. The A2A receptor-triggered generation of intracellular cAMP then inhibits activated immune cells in a delayed negative feedback manner to prevent additional tissue damage. Targeting A2A adenosine receptors may have important clinical applications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.immunol.22.012703.104731
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A preferred orientation of extragalactic double radio sources (1972)
    Springer
    Astrophysics and space science 17 (1972), S. 39-47 
    Details
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The distribution of the main axes of double radio sources is used to test isotropy of that part of the universe which is accessible to radio investigations. Data for 274 double and/or extended sources have been taken from the literature to compute the fit to several simple models of global orientation by means of a χ2-test. The best fit has been found on a 3%-significance level for the preferred orientation along a right-handed helix with pitch angle 82° in the direction α=95°, δ=−38° (1≅65°,b=≅20°). This preferential alignment of radio sources is assumed to be caused by a largescale magnetic field.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00642540
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Die Synthese von 16α,18-Dimethylcorticosteroiden (1975)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 108 (1975), S. 54-63 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: The Synthesis of 16α,18-DimethylcorticosteroidsThe syntheses of 16α,18-dimethylcorticoids 5, 7 and 9 starting from 21-acetoxy-6α-fluoro-16α,18-dimethyl-4-pregnen-3,20-dione (1) are described.
    Notes: Die Synthese der 16α,18-Dimethylcorticoide 5, 7 und 9 aus 21-Acetoxy-6α-fluor-16α,18-dimethyl-4-pregnen-3,20-dion (1) wird beschrieben.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19751080108
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    Paper (German National Licenses)
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