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  • 1
    Electronic Resource
    Electronic Resource
    Neuropeptide Y- and substance P-like immunoreactive nerve fibers in the rat dura mater encephali (1990)
    Springer
    Anatomy and embryology 182 (1990), S. 363-373 
    Details
    ISSN: 1432-0568
    Keywords: Neuropeptide Y ; Substance P ; Immunocytochemistry ; C-fibers ; Dura mater ; Dural sinus ; Meningeal arteries ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Density and pattern of nerve fibers with neuropeptide Y-like immunoreactivity (NPY-LI) and substance P-like immunoreactivity (SP-LI) in the rat dura mater encephali were investigated by light and electron microscopy using whole-mount preparations. NPY-LI fibers are observed throughout the encephalic dura mater. A remarkable net of NPY-LI nerve fibers is located in the walls of the sagittal and transverse sinuses. Beyond that NPY-LI network, distinct NPY-LI nerve fibers or plexus occur in the rostral falx, parietal dura mater of the olfactory bulb, supratentorial dura mater, parietal dura mater of the cerebellum, tentorium cerebelli and the ventral dura mater. Electron microscopic studies reveal that NPY-LI is exclusively located in unmyelinated axons of small and large nerve fiber bundles, with or without a perineural sheath. Immunopositive C-fibers are predominantly associated with the vascular bed. SP-LI nerve fibers have a moderate and more uniform distribution in the encephalic dura mater. A distinct plexus of SP-LI fibers follows the branches of the middle meningeal artery and the adjacent dura mater. SP-LI fibers are most prominent in the parietal dura mater of the cerebellum. Fine beaded SP-LI fibers, arising from larger SP-LI fiber bundles, are observed in close association to the capillary bed. SP-LI axons are all unmyelinated. They are found in larger nerve fiber bundles with a perineural sheath or in Schwann cells lacking any perineural sheath. The function of NPY-LI and SP-LI nerve fibers in the rat dura mater is discussed in relation to their topography, density and termination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02433496
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  • 2
    Electronic Resource
    Electronic Resource
    345. Histochemische Untersuchungen von intestinalen Metaplasmen der Magenschleimhaut beim Magencarcinom (1983)
    Springer
    Langenbeck's archives of surgery 361 (1983), S. 902-902 
    Details
    ISSN: 1435-2451
    Keywords: Carbohydrate histochemistry ; O-acetylated sialic acids ; Intestinal metaplasia ; Gastric carcinoma ; Carbohydrat-Histochemie ; O-acetylierte Sialinsduren ; Intestinale Metaplasie ; Magencarcinom
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die intestinale Metaplasie (IM) kann an Hand histochemischer und morphologischer Kriterien in einen Jejunumtyp und in einen Colontyp einerseits sowie in einen kompletten Typ und in einen inkompletten Typ andererseits unterschieden werden. Der prämaligne Charakter der Subtypen bleibt jedoch umstritten. Einzeln ausgezählte IM-Herde in 30 Ulcus- und Carcinommdgen zeigen ein überdurchschnittlich häufiges Auftreten von Sulphomucinen in der Carcinomgruppe. Eine histochemisch colondhnliche IM mit Nachweis von Sulphomucinen und substituierten Sialomucinen war dagegen in der Carcinomgruppe nicht häufiger nachweisbar.
    Notes: Summary Intestinal metaplasia (IM) can be divided morphologically and histochemically into a ‘ejunars' type and ‘colonic’ type, as well as a complete and incomplete type. The premalignant potential of the subtypes, however, remains controversial. Individually examined IM lesions in 30 stomachs resected for ulcer and carcinoma showed an exceptionally frequent occurrence of sulphomucins in the carcinoma group. A histochemically colon-like IM with detection of sulphomucins and O-acetylated sialomucins was not found to be more frequent in the carcinoma group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01276171
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  • 3
    Electronic Resource
    Electronic Resource
    340. Histochemische Frühdiagnostik beim Coloncarcinom (1983)
    Springer
    Langenbeck's archives of surgery 361 (1983), S. 900-900 
    Details
    ISSN: 1435-2451
    Keywords: Carcinoma of the colon ; Colonic mucin ; Sialic acid histochemistry ; Lectins ; Coloncarcinom ; Colonmucin ; Sialinsäure-Histochemie ; Lektine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In maligne entarteten Geweben sind unvollständig ausgebildete Glykokonjugate häufig. Zur Frühdiagnostik des Coloncarcinoms wurde daher zunächst die Kohlenhydratsequenz des normalen Colonmucins des Menschen untersucht. Mit Sialinsäure- und Lektin-histochemischen Methoden konnte gezeigt werden, daß die terminale O-Acylsialinsäure an das C-6-Atom des vorangehenden N-Acetylgalaktosamins gebunden ist. Daher ist zu vermuten, daß über den Lektin-histochemischen Nachweis Sialinsäure-freier N-Acetylgalaktosaminreste eine Frühdiagnose des Coloncarcinoms möglich ist.
    Notes: Summary Incomplete carbohydrate chains of glycoconjugates commonly occur in malignant tissue. For early diagnosis of carcinoma of the colon, the terminal carbohydrate sequence of normal human colonic mucin was investigated. A combination of sialic acid and lectin histochemical methods showed that the terminal O-acylsialic acids are bound to the carbon-6 of the preceding N-acetylgalactosamine moiety. Therefore, lectin histochemical detection of sialic-acid-free N-acetylgalactosamine residues may be of value for the early diagnosis of cancer of the colon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01276166
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  • 4
    Electronic Resource
    Electronic Resource
    Glutamate immunoreactivity is enriched over pinealocytes of the gerbil pineal gland (1994)
    Springer
    Cell & tissue research 278 (1994), S. 579-588 
    Details
    ISSN: 1432-0878
    Keywords: Key words: Pineal gland ; Pinealocytes ; Glutamate ; Postembedding immunogold staining ; Synaptic-like microvesicles ; Synaptophysin ; Meriones unguiculatus (Rodentia)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Mammalian pinealocytes have been shown to contain synaptic-like microvesicles with putative secretory functions. As a first step to elucidate the possibility that pinealocyte microvesicles store messenger molecules, such as neuroactive amino acids, we have studied the distributional pattern of glutamate immunoreactivity in the pineal gland of the Mongolian gerbil (Meriones unguiculatus) at both light- and electron-microscopic levels. In semithin sections of plastic-embedded pineals, strong glutamate immunoreactivity could be detected in pinealocytes throughout the pineal gland. The density of glutamate immunolabeling in pinealocytes varied among individual cells and was mostly paralleled by the density of immunostaining for synaptophysin, a major integral membrane protein of synaptic and synaptic-like vesicles. Postembedding immunogold staining of ultrathin pineal sections revealed that gold particles were enriched over pinealocytes. In particular, a high degree of immunoreactivity was associated with accumulations of microvesicles that filled dilated process terminals of pinealocytes. A positive correlation between the number of gold particles and the packing density of microvesicles was found in three out of four process terminals analyzed. However, the level of glutamate immunoreactivity in pinealocyte process endings was lower than in presumed glutamatergic nerve terminals of the cerebellum and posterior pituitary. The present results provide some evidence for a microvesicular compartmentation of glutamate in pinealocytes. Our findings thus lend support to the hypothesis that glutamate serves as an intrapineal signal molecule of physiological relevance to the neuroendocrine functions of the gland.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004410050248
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  • 5
    Electronic Resource
    Electronic Resource
    Differential distribution of five members of the matrix metalloproteinase family and one inhibitor (TIMP-1) in human liver and skin (1997)
    Springer
    Cell & tissue research 289 (1997), S. 173-183 
    Details
    ISSN: 1432-0878
    Keywords: Key words: Collagen ; Matrilysin (PUMP) ; Wound healing ; Tumors ; Fat-storing cells ; Peripheral nerve glial cells ; Fibrocytes ; Human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Matrix metalloproteinases represent a family of zinc-dependent proteolytic enzymes thought to be involved in normal and disease-related tissue remodeling processes. Increasing information about these enzymes is becoming available concerning their primary sequences, regulation at the mRNA level, activation of proenzymes, and modulation of enzyme activity by tissue inhibitors. In contrast, their morphological distribution and biological functions in normal tissues are poorly understood. In the present report, the comparative distribution of five members (gelatinase-A, gelatinase-B, matrilysin, stromelysin-1, and stromelysin-3) of the matrix metalloproteinase family and of one inhibitor (TIMP-1) has been morphologically analyzed in human liver and skin with the aid of new monospecific antibodies. Because of their common designation as matrix proteinases, these enzymes might have been expected to be distributed throughout these tissues, or at least in the connective tissue. However, each member of the family produces a highly specific pattern, staining structures such as arteriolar smooth muscle cells, myoepithelial cells in secretory portions or the luminal lining in excretory ducts of dermal sweat glands, liver bile canaliculi, or structures surrounding peripheral nerve axons. No reactivity is detected in rat tissues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004410050863
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Glutamate immunoreactivity is enriched over pinealocytes of the gerbil pineal gland (1994)
    Springer
    Cell & tissue research 278 (1994), S. 579-588 
    Details
    ISSN: 1432-0878
    Keywords: Pineal gland ; Pinealocytes ; Glutamate ; Postembedding immunogold staining ; Synaptic-like microvesicles ; Synaptophysin ; Meriones unguiculatus (Rodentia)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Mammalian pinealocytes have been shown to contain synaptic-like microvesicles with putative secretory functions. As a first step to elucidate the possibility that pinealocyte microvesicles store messenger molecules, such as neuroactive amino acids, we have studied the distributional pattern of glutamate immunoreactivity in the pineal gland of the Mongolian gerbil (Meriones unguiculatus) at both light- and electron-microscopic levels. In semithin sections of plastic-embedded pineals, strong glutamate immunoreactivity could be detected in pinealocytes throughout the pineal gland. The density of glutamate immunolabeling in pinealocytes varied among individual cells and was mostly paralled by the density of immunostaining for synaptophysin, a major integral membrane protein of synaptic and synaptic-like vesicles. Postembedding immunogold staining of ultrathin pineal sections revealed that gold particles were enriched over pinealocytes. In particular, a high degree of immunoreactivity was associated with accumulations of microvesicles that filled dilated process terminals of pinealocytes. A positive correlation between the number of gold particles and the packing density of microvesicles was found in three out of four process terminals analyzed. However, the level of glutamate immunoreactivity in pinealocyte process endings was lower than in presumed glutamatergic nerve terminals of the cerebellum and posterior pituitary. The present results provide some evidence for a microvesicular compartmentation of glutamate in pinealocytes. Our findings thus lend support to the hypothesis that glutamate serves as an intrapineal signal molecule of physiological relevance to the neuroendocrine functions of the gland.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00331377
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    Paper (German National Licenses)
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