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  • 1
    Electronic Resource
    Electronic Resource
    Primary cutaneous plasmacytoma: a role for a triggering stimulus? (2005)
    Oxford, UK : Blackwell Science Ltd
    Clinical and experimental dermatology 30 (2005), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Primary cutaneous plasmacytoma is a rare type of cutaneous B-cell lymphoma, characterized by clonal proliferation of plasma cells, that primarily develops in the skin. Five cases have been described to date in which a local triggering stimulus may be involved in development of this skin tumour. We describe the case of a primary cutaneous plasmacytoma localized to the lower lip. This site had been affected for 15 years with recurrent herpes simplex virus-1 infection. Neoplastic plasma cells were found to be bcl-2-positive. We hypothesize that chronic stimulation of keratinocytes by herpes simplex virus-1, possibly through toll-like receptors, may have favoured the release of cytokines (e.g. interleukin-6) able to induce plasma cell proliferation, transformation and survival.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.2004.01692.x
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  • 2
    Electronic Resource
    Electronic Resource
    MRI of Wolfram syndrome (DIDMOAD) (1999)
    Springer
    Neuroradiology 41 (1999), S. 729-731 
    Details
    ISSN: 1432-1920
    Keywords: Key words DIDMOAD syndrome ; Wolfram syndrome ; substantia nigra ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Wolfram syndrome (DIDMOAD) is a rare diffuse neurodegenerative disorder characterised by diabetes insipidus, diabetes mellitus, optic atrophy, deafness, and a wide variety of abnormalities of the central nervous system, urinary tract and endocrine glands. It may be familial or sporadic. Reported features on MRI of the brain are absence of the physiological high signal of the posterior lobe of the pituitary, shrinkage of optic nerves, chiasm and tracts, atrophy of the hypothalamic region, brain stem, cerebellum, and cerebral cortex. We report a 12-year-old girl with a 5-year history without brain stem, cerebellar or cerebral atrophy. MRI showed an unusual feature: a focus of high signal on PD- and T2-weighted images in the right substantia nigra. This is consistent with previously reported neuropathological post-mortem studies, but has never been reported in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050832
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  • 3
    Electronic Resource
    Electronic Resource
    Antibacterial activity of Penicillium spp. strains isolated in extreme environments (2000)
    Springer
    Polar biology 23 (2000), S. 294-297 
    Details
    ISSN: 1432-2056
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Penicillium spp. isolated from the sediments of ponds in continental Antarctica have been studied and compared with species obtained from similar environments in the Apennines of the Liguria region, in northwestern Italy. The antibacterial activity exhibited by some strains was evaluated against standard strains using both liquid and solid media. The preliminary data suggest an antibacterial activity similar to β-lactam antibiotics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003000050447
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  • 4
    Electronic Resource
    Electronic Resource
    Involvement of atlanto-axial joint in rheumatoid arthritis: Rare or frequent? (1994)
    Springer
    Clinical rheumatology 13 (1994), S. 459-463 
    Details
    ISSN: 1434-9949
    Keywords: Rheumatoid Arthritis ; Computerized Tomography ; Atlanto-axial Joint
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The authors studied the incidence of atlanto-axial joint involvement by conventional radiography and CT in 183 patients with classical or definite rheumatoid arthritis (RA). In determining lesions the significance of factors such as age, sex, duration and severity of the disease was evaluated. Atlanto-axial subluxations turned out to be quite frequent (30%) in the series of patients examined and were directly correlated with age, duration and stage of the disease, and extra-articular manifestations. Clinical symptoms were evident in only 70.9% of cases, confirming the correlation reported by other authors between clinical manifestations and radiologically observed lesions. Traditional radiography performed in the dynamic position revealed a prevalence of anterior subluxation, whereas CT gave a precise indication of the entity and type of atlanto-axial lesion. In conclusion, the authors confirm the importance of such investigations in all patients with RA, even those without evident clinical manifestations. They also emphasize the necessity of periodic monitoring in view of the possible risk of mortality in these patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02242943
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  • 5
    Electronic Resource
    Electronic Resource
    Functional and morphological changes in small bowel of crohn's disease patients (1995)
    Springer
    Digestive diseases and sciences 40 (1995), S. 1388-1393 
    Details
    ISSN: 1573-2568
    Keywords: Crohn's disease ; intestinal permeability ; disaccharidases ; thymidine kinase ; disease activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Morphological and functional changes were examined in the upper jejunum and terminal ileum of 18 patients suffering from Crohn's disease. Intestinal permeability, biochemical determination of enzymatic activities, and morphologic evaluation of the severity of the lesions were evaluated. Ulcerative colitis and irritable bowel syndrome patients served as controls. We found abnormal lactulose-mannitol tests in all patients with active Crohn's disease. Permeability changes correlated with increased crypt cell proliferation, as indicated by thymidine kinase activity. A significant reduction in brush border enzyme activities was seen in the terminal ileum, but no significant change was observed in the unaffected upper jejunum. The number of mast cells was increased in the diseased ileum. We conclude that the site of inflammation and the healing capacity of the epithelium are important in determining functional and biochemical abnormalities in active Crohn's disease. Changes may be dependent on the type and number of immune cells involved in the inflammatory process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02065556
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  • 6
    Electronic Resource
    Electronic Resource
    Cervical myelopathy secondary to ossification of the posterior longitudinal ligament (a case report) (1984)
    Springer
    Neurological sciences 5 (1984), S. 203-207 
    Details
    ISSN: 1590-3478
    Keywords: Cervical myelopathy ; longitudinal ligament ossification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Viene riportato un caso di ossificazione del legamento longitudinale posteriore, documentato con Rx, mielografia e TAC della colonna vertebrale. Il paziente è stato sottoposto a laminectomia decompressiva per via posteriore, con miglioramento della sintomatologia. II caso viene discusso alla luce degli altri dati della letteratura.
    Notes: Abstract A case of ossification of the posterior longitudinal ligament, documented by spinal X-ray, myelography and CT scanning of the spinal cord is reported. The patient underwent decompressive laminectomy by posterior approach, which was successful. The case is discussed in the light of recent published data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02043224
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