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  • 1
    Electronic Resource
    Electronic Resource
    Tyrosine hydroxylase-negative, dopaminergic neurons are targets for transmitter-depleting action of haloperidol in the snail brain (1996)
    Springer
    Cellular and molecular neurobiology 16 (1996), S. 451-461 
    Details
    ISSN: 1573-6830
    Keywords: antipsychotic ; neuroleptic ; gastropod ; monoamine ; catecholamine ; serotonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. The effects of long term administration of micromolar concentrations of the D2 antagonist haloperidol upon monoaminergic neurons in the snailLymnaea stagnalis was investigated. 2. Treatment by bath application with 0.5–2.0 micromolar haloperidol, caused a significant, continuous depletion of dopamine levels in the nervous system as revealed by high performance liquid chromatography. 3. A transient depletion of serotonin was also observed, but DOPA and norepinephrine levels were unaffected. Similar depletion of dopamine was observed after the land snail,Achatina fulica, was injected with haloperidol on each of 4 consecutive days. 4. The depletion of dopamine as revealed with glyoxylate-induced fluorescence inLymnaea appears to be restricted to a subpopulation of catecholaminergic neurons which are immuno-negative for tyrosine hydroxylase, the synthetic enzyme responsible for the conversion of tyrosine to DOPA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02150226
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Transient and sustained expression of FMRFamide-like immunoreactivity in the developing nervous system ofLymnaea stagnalis (mollusca, pulmonata) (1996)
    Springer
    Cellular and molecular neurobiology 16 (1996), S. 661-676 
    Details
    ISSN: 1573-6830
    Keywords: gastropod ; mollusc ; development ; neuropeptides ; FMRFamide ; immunoreactivity ; Lymnaea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. In the present study we have investigated the ontogeny of FMRFamide expression in the snail,Lymnaea stagnalis, from its first appearance to its distribution in young adults. 2. The first FMRFamide-like immunoreactive (FaLI) cells within CNS appear by E45 embryonic stage (premetamorphic veliger). The number of FaLI neurons increases throughout both pre- and post-hatching development. 3. Both transient and sustained expression of FMRFamide-like immunoreactivity by specific sets of neurons occurs. Two cells which transiently express immunoreactivity appear outside the future CNS by the stage E45. Other population of transient FaLI neurons includes bilaterally symmetric groups of cells in the cerebral and pedal ganglia during posthatching stages P1 (hatchlings) to P5 (juveniles). All other immunostained cells which appear during development maintain their transmitter phenotype into adulthood. 4. The possible role of FMRFamide-related peptides in the processes of morpho- and neurogenesis is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02151903
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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