ISSN:
1600-0625
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
We investigated the effects of repeated broadband UVB (UVB-BB) and repeated narrowband UVB (UVB-NB) on intraepidermal nerve fibers (ENF) immunoreactive (IR) for CGRP and on CHS to DNFB in hairless mice. Mice were exposed to equivalent subinflammatory UVB-BB (Kodacel-filtered FS20) or UVB-NB (TL01) 3× per week for 4 weeks. One, 3, or 7 days after the last UV exposure, the number of CGRP-IR ENF was determined in exposed back skin. At the same time points, other mice were sensitized to DNFB on exposed back skin, challenged on abdominal skin 5 days later, and skin swelling was determined at 24 h after challenge. UVB-BB and UVB-NB significantly increased the number of CGRP-IR ENF in exposed back skin and significantly suppressed the sensitization of animals to DNFB. For both treatments, these effects were maximal 1 day after the last UV exposure. However, at 7 days after the last UV exposure, in UVB-NB-irradiated animals, the number of CGRP-IR ENF was still significantly increased and the sensitization to DNFB significantly suppressed, while in UVB-BB-irradiated animals, these parameters were similar to that in non-irradiated controls. Thus, while repeated exposure to UVB-BB or UVB-NB or both induced increase of CGRP-IR ENF as well as local immunosuppression, the effects after repeated UVB-NB were prolonged compared with that after repeated UVB-BB. This may contribute to the higher phototherapeutic efficacy of UVB-NB vs. UVB-BB.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.0906-6705.2004.0212bs.x
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