ISSN:
0170-2041
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Description / Table of Contents:
Albomycins, II. - Absolute Configuration of the Deferri Form of the AlbomycinsChemical and enzymatic hydrolyses afford the degradation products of the albomycins δ2, δ1, and ε (1a - c). The absolute configuration of these degradation products or of there derivatives could be elucidated by the combination of chiroptical, gaschromatographic, and NMR (NOE) spectroscopic methods. N5-Acetyl-N5-hydroxyornithine (4) and serine (3) exist in the L-configuration, while the nucleoside contains the 6-amino-6-deoxy-4-thio-L-glycero-α-L-ido-heptofuranuronic acid. The configuration of this nucleoside could also be established by the X-ray analysis of the sulfoxide 21.
Notes:
Chemische und enzymatische Hydrolysen führen zu Abbauprodukten der Albomycine δ2, δ1 und ε (1a - c). Die absoluten Konfigurationen der Abbauprodukte oder deren Derivate werden durch Kombination chiroptischer, gaschromatographischer und NMR-spektroskopischer (NOE) Methoden abgeleitet. N5-Acetyl-N5-hydroxyornithin (4) und Serin (3) liegen in der L-Konfiguration vor, während das Nucleosid die 6-Amino-6-desoxy-4-thio-L-glycero-α-L-ido-heptofuranuronsäure enthält. Die Konfiguration des Nucleosids wird unabhängig davon durch die Röntgenstrukturanalyse des kristalline Sulfoxids 21 belegt.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.198419840803
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