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  • 1
    Electronic Resource
    Electronic Resource
    Procollagen-III peptide serum levels in Paget's disease of the bone (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 174-178 
    Details
    ISSN: 1432-1440
    Keywords: Procollagen-III peptide ; Paget's disease of the bone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A commercially available radioimmunoassay kit was used to determine aminoterminal procollagen-III peptide (pNcoll III) serum levels in patients with Paget's disease of the bone and control subjects. In patients with Paget's disease pNcoll III concentrations were significantly elevated. They decreased to varying degrees under chronic therapy with human and salmon calcitonin, disodium ethane 1-hydroxy 1,1 diphosphonate (EHDP), or a combination therapy of EHDP and human calcitonin. The results were compared with the effect on traditional biochemical markers of disease activity: serum alkaline phosphatase and urinary hydroxyproline excretion, both of which reacted more acutely to the various therapies than pNcoll III, although pretreatment correlations were close. The most probable source of pNcoll III is not the Pagetic bone per se, but the vascular, fibrous connective tissue replacing normal bone marrow.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728230
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  • 2
    Electronic Resource
    Electronic Resource
    Sedation with intravenous infusions of propofol or thiopentone (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 50 (1995), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The aim of this study was to investigate pain perception during thiopentone or propofol infusions for sedation. Thirty ASA 1 or 2 patients received a two step infusion of either thiopentone (step 1: 1.25 mg.kg-1 followed by 2.5 mg.kg-1.h-1; step 2: 1.25 mg.kg-1 and 12.5 mg.kg-1.h-1; n = 15) or propofol (step 1: 0.5 mg.kg-1, 1 mg.kg-1.h-1; step 2: 0.5 mg.kg-1, 5 mg.kg-1.h-1; n = 15) for sedation. At control and 10 min after the start of each infusion dosage, reaction times and thermal pain detection thresholds were determined. We found no clinically or statistically significant depression of thermal pain detection thresholds during propofol or thiopentone infusions and these are, therefore, unlikely to be associated with clinically relevant hyperalgesia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1995.tb04560.x
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  • 3
    Electronic Resource
    Electronic Resource
    Esomeprazole 40 mg i.v. provides faster and more effective intragastric acid control than pantoprazole 40 mg i.v.: results of a randomized study (2004)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 20 (2004), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Oral esomeprazole 40 mg provides greater acid control than oral pantoprazole 40 mg.Aim : To compare the effects on intragastric acid control of esomeprazole 40 mg administered intravenously with pantoprazole 40 mg intravenously.Methods : Healthy Helicobacter pylori-negative male and female subjects were enrolled into this single-centre, open, randomized, two-way crossover study. Esomeprazole 40 mg intravenously and pantoprazole 40 mg intravenously were administered as 15-min infusions once daily at 09:00 hours for 5 days. Continuous 24-h intragastric pH monitoring was carried out at baseline and on days 1 and 5.Results : pH-data were available for all 25 subjects who completed the study. Esomeprazole 40 mg intravenously resulted in 8.3 and 13.9 h with an intragastric pH 〉 4 on days 1 and 5 compared with 5.3 and 9.0 h, respectively for pantoprazole 40 mg intravenously (day 1: P 〈 0.001, day 5: P 〈 0.0001). During the first 4 h of dosing on day 1 corresponding values were 1.7 and 0.6 h respectively (P 〈 0.0001). A mean median pH above 4 on day 5 was only attained with esomeprazole 40 mg intravenously.Conclusions : Once-daily dosing with esomeprazole 40 mg intravenously provides faster and more pronounced intragastric acid control than pantoprazole 40 mg intravenously.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2004.02272.x
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  • 4
    Electronic Resource
    Electronic Resource
    Gastrospirillum hominis in asymptomatic, healthy individuals (1993)
    Springer
    Digestive diseases and sciences 38 (1993), S. 2087-2089 
    Details
    ISSN: 1573-2568
    Keywords: Gastrospirillum hominis ; healthy subjects ; gastritis ; Helicobacter pylori ; prevalence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Gastrospirillum hominis is a spiral-shaped bacterium found in the stomach. It has been implicated as a possible cause of chronic gastritis. We report two cases ofG. hominis colonization observed in a series of 175 healthy, asymptomatic volunteers investigated forHelicobacter pylori. None of the volunteers has symptoms or a history of gastrointestinal disease. Both carriers ofG. hominis had histological signs of chronic, active antral gastritis. Multiple tests forH. pylori were negative. The prevalence of this spiral bacterium in healthy, asymptomatic individuals may be as low as in symptomatic persons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01297089
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  • 5
    Electronic Resource
    Electronic Resource
    Tolerance and rebound to H2-receptor antagonists: Intragastric acidity in patients with duodenal ulcer (1991)
    Springer
    Digestive diseases and sciences 36 (1991), S. 1685-1690 
    Details
    ISSN: 1573-2568
    Keywords: H2-receptor antagonists ; continuous 24-hr pH monitoring ; duodenal ulcer ; tolerance ; rebound hyperacidity ; intragastric acidity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Tolerance to the antisecretory effects of H2-receptor antagonists develops consistently in healthy volunteers. The aim of this study was to determine whether tolerance occurs with repeated dosing of H2-receptor antagonists in patients with duodenal ulcer. Continuous intragastric 24-hr pH measurements were performed in 12 patients with duodenal ulcer in symptomatic remission before, on days 1 and 29, and two days after receiving ranitidine 300 mg four times a day for 34 days. The 24-hr median intragastric pH (interquartile range) was 5.4 (4.4–6.1) on day 1 and 4.6 (4.0–5.2) on day 29 of dosing with ranitidine (not significant). Median nighttime pH was 6.8 (6.3–7.0) on day 1 and 6.8 (6.6–7.1) on day 29 (not significant). During the daytime, the median pH decreased marginally from 4.7 (3.8–5.2) on day 1 to 3.8 (3.0–4.6) on day 29 (P〈0.03). There was no difference in median intragastric pH during 24-hr, day and night periods before and two days after ranitidine dosing. No significant tolerance or rebound to H2-receptor antagonists was observed in patients with duodenal ulcer disease. This contrasts with data gathered in healthy volunteers and may be due to defects in the regulation of acid secretion in duodenal ulcer disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01296610
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  • 6
    Electronic Resource
    Electronic Resource
    Cigarette smoking, gastric acidity and peptic ulceration (1990)
    Springer
    Digestive diseases and sciences 35 (1990), S. 1482-1487 
    Details
    ISSN: 1573-2568
    Keywords: peptic ulcer ; gastric acidity ; pH monitoring ; smoking
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The influence of cigarette smoking on intragastric acidity was assessed in duodenal ulcer patients in symptomatic remission and in healthy volunteers in a retrospective study. Continuous 24-hr pH recordings in 150 nonsmokers and 174 smokers receiving placebo treatment were compared. Daytime intragastric acidity was higher in smokers with a median pH (interquartile range) of 1.56 (1.34–1.80) than in nonsmokers, who had a median pH of 1.70 (1.45–1.97) (P〈0.001). There was no difference in 24-hr and nighttime median pH between the two groups. The small difference in daytime intragastric acidity in smokers and nonsmokers is unlikely to account for the increased prevalence of peptic ulcer disease in smokers. The analysis of smoking status in duodenal ulcer patients and healthy controls and males and females supports the general trend towards higher daytime acidity in smokers. Again, no differences in pH during the 24-hr or night period were found between the groups. The epidemiological and clinical correlation between smoking and duodenal ulcer disease is not adequately explained by increased intragastric acidity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01540565
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  • 7
    Electronic Resource
    Electronic Resource
    Tolerance to oral H2-receptor antagonists (1990)
    Springer
    Digestive diseases and sciences 35 (1990), S. 976-983 
    Details
    ISSN: 1573-2568
    Keywords: 24-hour pH-metry ; tolerance ; ranitidine ; famotidine ; acid inhibition ; pharmacodynamics ; H2-receptor antagonists
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The acid-inhibitory action of H2-receptor antagonists was shown to decrease after one to two weeks of dosing in healthy volunteers. This tolerance was evaluated in three randomized, placebo-controlled trials with the H2-receptor antagonists famotidine, 40 mg given after the evening meal for 28 days; ranitidine, 300 mg four times a day for seven days followed by 300 mg at night until day 28; and ranitidine, 300 mg three times a day vs 300 mg at night for 14 days. Continuous 24-hr pH monitoring with glass electrodes was performed under fed conditions. The median 24-hr pH decreased from 3.2 on day 1 with famotidine 40 mg to 1.9 on day 28 (P〈0.0012). After seven days of dosing with ranitidine 300 mg four times a day the median 24-hr pH dropped from 5.0 on day 1 to 3.0 on day 7 (P〈0.001) and then to 2.2 with ranitidine 300 mg at night on day 28. With ranitidine 300 mg three times a day the median 24-hr pH fell from 4.3 on day 1 to 2.4 on day 14 (P〈 0.0005). With ranitidine 300 mg at night the respective pH values were 2.5 and 1.8 (P〈 0.003). Tolerance to H2-receptor antagonists given in a single evening dose was only evident during the night, whereas tolerance occurred throughout the day and night with the three- and four-times-a-day regimens. A large increase in the interindividual variability of pH response was seen during the nighttime.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01537246
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