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  • 1
    Electronic Resource
    Electronic Resource
    Determinants of a normal (versus impaired) oral glucose tolerance after combined pancreas-kidney transplantation in IDDM patients (1996)
    Springer
    Diabetologia 39 (1996), S. 462-468 
    Details
    ISSN: 1432-0428
    Keywords: Pancreas transplantation ; insulin secretion ; pancreatic hormones ; oral glucose tolerance ; glucagon stimulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary After successful pancreas transplantation, insulin-dependent diabetic patients are characterized by a normal or at worst impaired oral glucose tolerance (World Health Organisation criteria). It is not known which pathophysiological mechanisms cause the difference between normal and impaired oral glucose tolerance. Therefore, we studied 41 patients after successful combined pancreas-kidney transplantation using stimulation in the fasting state with oral glucose (75 g), intravenous glucose (0.33 g/kg) and glucagon bolus injection (1 mg i.v.). Glucose (glucose oxidase), insulin and C-peptide (immunoassay) were measured. Repeated-measures analysis of variance and multiple regression analysis were used to analyse the results which showed: 28 patients had a normal, and 13 patients had an impaired oral glucose tolerance. Impaired oral glucose tolerance was associated with a greatly reduced early phase insulin secretory response (insulin p〈0.0001; C-peptide p=0.037). Age (p=0.65), body mass index (p=0.94), immunosuppressive therapy (cyclosporin A p=0.84; predniso(lo)ne p=0.91; azathioprine p=0.60) and additional clinical parameters were not different. Reduced insulin secretory responses in patients with impaired oral glucose tolerance were also found with intravenous glucose or glucagon stimulations. Exocrine secretion (α-amylase in 24-h urine collections) also demonstrated reduced pancreatic function in these patients (−46%; p=0.04). Multiple regression analysis showed a significant correlation of 120-min glucose with ischaemia time (p=0.003) and the number of HLA-DR mismatches (p=0.026), but not with HLA-AB-mismatches (p=0.084). In conclusion, the pathophysiological basis of impaired oral glucose tolerance after pancreas transplantation is a reduced insulin secretory capacity. Transplant damage is most likely caused by perioperative influences (ischaemia) and by the extent of rejection damage related, for example, to DR-mismatches.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400678
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  • 2
    Electronic Resource
    Electronic Resource
    Determinants of a normal (versus impaired) oral glucose tolerance after combined pancreas-kidney transplantation in IDDM patients (1996)
    Springer
    Diabetologia 39 (1996), S. 462-468 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Pancreas transplantation ; insulin secretion ; pancreatic hormones ; oral glucose tolerance ; glucagon stimulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary After successful pancreas transplantation, insulin-dependent diabetic patients are characterized by a normal or at worst impaired oral glucose tolerance (World Health Organisation criteria). It is not known which pathophysiological mechanisms cause the difference between normal and impaired oral glucose tolerance. Therefore, we studied 41 patients after successful combined pancreas-kidney transplantation using stimulation in the fasting state with oral glucose (75 g), intravenous glucose (0.33 g/kg) and glucagon bolus injection (1 mg i. v.). Glucose (glucose oxidase), insulin and C-peptide (immunoassay) were measured. Repeated-measures analysis of variance and multiple regression analysis were used to analyse the results which showed: 28 patients had a normal, and 13 patients had an impaired oral glucose tolerance. Impaired oral glucose tolerance was associated with a greatly reduced early phase insulin secretory response (insulin p 〈 0.0001; C-peptide p = 0.037). Age (p = 0.65), body mass index (p = 0.94), immunosuppressive therapy (cyclosporin A p = 0.84; predniso(lo)ne p = 0.91; azathioprine p = 0.60) and additional clinical parameters were not different. Reduced insulin secretory responses in patients with impaired oral glucose tolerance were also found with intravenous glucose or glucagon stimulations. Exocrine secretion (α-amylase in 24-h urine collections) also demonstrated reduced pancreatic function in these patients (–46 %; p = 0.04). Multiple regression analysis showed a significant correlation of 120-min glucose with ischaemia time (p = 0.003) and the number of HLA-DR mismatches (p = 0.026), but not with HLA-AB-mismatches (p = 0.084). In conclusion, the pathophysiological basis of impaired oral glucose tolerance after pancreas transplantation is a reduced insulin secretory capacity. Transplant damage is most likely caused by perioperative influences (ischaemia) and by the extent of rejection damage related, for example, to DR-mismatches. [Diabetologia (1996) 39: 462–468]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400678
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  • 3
    Electronic Resource
    Electronic Resource
    Cosmic ray tracking - a new approach to high-energy γ-astronomy
    Amsterdam : Elsevier
    Nuclear Instruments and Methods in Physics Research Section A: 315 (1992), S. 257-259 
    Details
    ISSN: 0168-9002
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0168-9002(92)90711-C
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  • 4
    Electronic Resource
    Electronic Resource
    Cosmic ray tracking - a new approach to high-energy γ-astronomy
    Amsterdam : Elsevier
    Nuclear Instruments and Methods in Physics Research Section A: 323 (1992), S. 60-64 
    Details
    ISSN: 0168-9002
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0168-9002(92)90269-A
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  • 5
    Electronic Resource
    Electronic Resource
    Book reviews (1993)
    Springer
    European food research and technology 197 (1993), S. 453-456 
    Details
    ISSN: 1438-2385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01202617
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  • 6
    Electronic Resource
    Electronic Resource
    Trauma of the torso and the urogenital tract in Alpine skiiers (1990)
    Springer
    World journal of urology 7 (1990), S. 223-226 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Approximately 375000 people living in West Germany take out special skiing insurance. More than 90% of the skiing accidents occurring in this population during four consecutive winters could be registered and analyzed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01576347
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  • 7
    Electronic Resource
    Electronic Resource
    Overview of the West German Urological Multicenter Study Traumatology (1990)
    Springer
    World journal of urology 7 (1990), S. 227-234 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A total of 385 patients (83% men, 52% aged 16–30) with urogenital (UG) trauma were treated in 19 urological clinics between April 1984 and December 1986. In all, 41% of the accidents were due to traffic; 13% to work and sports each; 8% to sexual activities; and 6% to violence. The distribution of injury severity included 40% light, 21% moderate and 39% severe. Of 427 UG lesions, 27% were combined with intraabdominal and 24% with pelvic injuries. The kidneys were involved in 51% of cases and the bladder, urethra, penis and scrotum, including its content, in ca. 10% each. Of the renal traumas, 49% were ruptures; 48% contusions; and 7% hilar lesions,a nd in 6% the complete destruction of the organ occurred. In all, 76% of these traumas were treated conservatively, whereas 8% each required reconstruction or nephrectomy. Amongst the urethral ruptures, 46% were complete; 39% partial posterior; and 11% ruptures of the penile urethra. In 43% of cases the treatment was conservative and in 41% a primary reconstruction was carried out. All intraperitoneal (43%) and 2/3 of the extraperitoneal bladder ruptures (57%) were operated on. Gross hematuria was found in 73% of the renal, 83% of the vesical and 73% of the urethral injuries. Microhematuria occurred in 24%, 9% and 13% of cases, whereas no hematuria was found in 3%, 5% and 13% of the kidney, bladder and urethral injuries, respectively. The injury-relevant sensitivity of the imaging methods was computed to be 95% for cystograms, 91% for urethrograms and 83% for angiograms. When used to screen trauma patients, the sensitivity proved to be 69% for the CT scan, 55% for the intravenous pyelogram (IVP) and 54% for sonography. Overall, 37% of 161 complications involved the UG tract, followed by neurological complications, those due to the operation or treatment, to infections or to organ failure. In all, 11% of patients remained in the hospital for only 1 day; 50% for up to 13 days; 20% for 14–60 days; and 17% for 〉60 days.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01576348
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  • 8
    Electronic Resource
    Electronic Resource
    Fortlaufende Registrierung der Rectaltemperatur des Menschen unter extremen Bedingungen (1971)
    Springer
    Pflügers Archiv 327 (1971), S. 186-190 
    Details
    ISSN: 1432-2013
    Keywords: Rectal Temperature in Man ; Continuous Recording ; Extreme Environmental Conditions ; Circadian Rhythms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rectal temperature in man is a function of various conditions (e.g. time of day, ambient temperature, work load, oxygen level), whose effects interact with each other in a manner so far mostly unknown. Therefore, it would be desirable not only to make measurements of rectal temperature with these conditions changed separately but also long time recordings under extreme conditions in the field. In order to facilitate this, small battery operated thermographs (90×70×30 mm; 350 g), with small thermistor probes, were developed which allow continuous recording of rectal temperature under extreme environmental conditions without inconvenience to the subjects. Precision in temperature is better than 0.1°C; precision in time after recordings of many weeks duration (with weekly changes of the recording disc) is better than 0.5 h. An exemplum is shown demonstrating the diurnal course of rectal temperature averaged over 1 week, recorded during a mountain climbing expedition to heights of 5000–7000 m, with temperatures between +20°C and −20°C.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587369
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  • 9
    Electronic Resource
    Electronic Resource
    Cumulation and elimination of horse-anti-dog lymphocyte and normal horse gammaglobulin in dogs (1976)
    Springer
    Research in experimental medicine 167 (1976), S. 231-238 
    Details
    ISSN: 1433-8580
    Keywords: Antilympocyte Globulin ; Immunosuppression ; Elimination of Gamma-Globulin ; Antilymphozytenglobulin ; Immunsuppression ; Gammglobulinelimination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zwei Gruppen von Hunden wurden elf Tage lang mit 20 mg/kg 131-I-markiertem Pferde-anti-human-Lymphozyten-Globulin bzw. Normal-Pferde-Gammaglobulin i.v. behandelt. Pferde-anti-human-Lymphozyten-Globulin wurde signifikant schneller eliminiert als Normal-Pferde-Gammaglobulin. Im Gegensatz zu dem kontinuierlichen Anstieg der Serum-Radioaktivität unter Normal-Pferde-Gammaglobulin-Behandlung war in der Pferde-anti-human-Lymphozyten-Globulin-Gruppe ab dem 5. Tag eine Plateaubildung zu beobachten. Zum Behandlungsende betrug die Serumkonzentration des xenogenen Proteins 165 ± 8 mg/1 in der Pferde-anti-human-Lymphozyten-Globulin- und 498 ± 15 mg/1 in der Normal-Pferde-Gammaglobulin-Gruppe. Die Pferde-anti-human-Lymphozyten-Globulin-behandelten Tiere zeigten einen signifikant höheren Anstieg agglutinierender Antikörper gegen Pferde-Erythrozyten als Normal-Pferde-Gammaglobulin-behandelte Tiere. Diese starke Immunogenizität von antilymphozytärem Pferde-Gammaglobulin muß bei der Applikation von Pferde-anti-human-Lymphozyten-Globulin berücksichtigt werden.
    Notes: Summary Two groups of dogs received daily intravenous doses of 20 mg/kg 131-I-labelled horse-anti-dog lymphcyte globulin or normal horse gammaglobulin respectively over a period of 11 days. Horse-anti-dog lymphocyte globulin showed a significantly higher eleimination rate than normal horse gammaglobulin. In contrary to the continuous increase in serum radioactivity during normal horse gammaglobulin treatment, there was a plateau after the 5th day in the horse-anti-dog lymphocyte globulin group. The xenogeneic protein concentration, measured with the single radial immunodiffusion technique, at the end of treatment was 165 ± 8 mg/1 in the horse-anti-dog lymphocyte globulin, compared to 498 ± 15 mg/1 in the normal horse gammaglobulin group. After treatment horse-anti-dog-lymphcyte globulin treated animals showed a significantly higher increase in active hemagglutination titer against horse erythrocytes with an average of 2−8.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851647
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