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  • 1
    Electronic Resource
    Electronic Resource
    Lichen sclerosus is frequently present in penile squamous cell carcinomas but is not always associated with oncogenic human papillomavirus (2003)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 148 (2003), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Background Penile squamous cell carcinoma (SCC) may occur on pre-existing lesions of lichen sclerosus (LS). However, the prevalence of histological changes of LS in penile SCC is not well established. Moreover, mucosal oncogenic human papillomaviruses (HPVs) are sometimes detected in penile SCC, but have not been systematically sought in LS-associated penile SCC. Objectives To establish the prevalence of LS histological changes and of mucosal oncogenic HPV in a series of patients with penile SCC. Methods Consecutive cases of histologically proven penile SCC from a single university hospital over a 14-year period were retrospectively selected and reviewed. Histological signs of LS were systematically sought. HPV was detected by polymerase chain reaction (PCR) amplification of DNA from paraffin-embedded skin samples using general primers GP5+/GP6+ (allowing detection of mucosal HPV) and oncogenic type 16-, 18-, 31- and 33-specific primers. Results Eighteen cases of penile SCC were found. The mean ± SD age of patients at diagnosis was 67·3 (14·5 years). In eight of 18 (44%) cases, SCC was associated with histological features of LS. Seventeen skin biopsy specimens of SCC (nine without and eight with LS histology) were subjected to PCR amplification for HPV. Mucosal HPV was detected in six of them (35%). Five of nine SCCs without histological features of LS were positive for mucosal HPV: three with HPV type 16 and two with only general primers. In contrast, all eight SCCs associated with LS were negative for oncogenic HPV types, although one was positive with general primers. Conclusions Penile SCC seems to be frequently associated with LS histological changes. As with vulval SCC, we found that non-LS-associated penile SCC tended to be frequently associated with oncogenic HPV infection, whereas LS-associated penile SCC was not. Larger series are needed to confirm this association.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2003.05326.x
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  • 2
    Electronic Resource
    Electronic Resource
    Contribution to the diagnosis and follow-up of bladder tumours by KL1 monoclonal antibody
    Amsterdam : Elsevier
    Biology of the Cell 73 (1991), S. 41 
    Details
    ISSN: 0248-4900
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0248-4900(91)90226-D
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  • 3
    Electronic Resource
    Electronic Resource
    Quantitative immunolocalization of four immunodominant antigens of Toxoplasma gondii
    Amsterdam : Elsevier
    Biology of the Cell 73 (1991), S. 89-97 
    Details
    ISSN: 0248-4900
    Keywords: Toxoplasma gondii ; image analysis ; immunocytochemistry ; immunodominant antigen ; morphometric quantitation
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0248-4900(91)90013-D
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  • 4
    Electronic Resource
    Electronic Resource
    Etude histologique et histochimique des lésions induites au niveau du poumon de souris par un carcinogène: le N-nitroso-N methylurethane (1970)
    Springer
    Journal of cancer research and clinical oncology 74 (1970), S. 227-235 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Resume L'injection parentérale d'un carcinogène chimique, le N-nitroso-N méthyluréthane, détermine au niveau du poumon de souris des foyers de prolifération atypique associés à un intense processus de pneumonie réticulée hypertrophique. Les auteurs étudient d'une part la morphologie de telles lésions et d'autre part en explorent certains aspects métaboliques par les méthodes histochimiques. L'étude des hydrolases, en particulier des phosphatases alcaline, apparait importante à considérer, notamment au niveau de la circulation capillaire.
    Notes: Summary Parenteral injections of a chemical carcinogen, N-nitroso-N methylurethane, produces in the lung of mice foci of atypical proliferation associated with intense alveolar collapse. The morphology of these lesions is presented, then their metabolic features as determined by histochemical methods. The activity of hydrolases especially of alkaline phosphatases, appears to be important, particularly in the capillary circulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00525455
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  • 5
    Electronic Resource
    Electronic Resource
    Hémangio-endothélio-sarcome splénique avec érythrophagocytose et angiopathie thrombotique (1972)
    Springer
    Virchows Archiv 356 (1972), S. 66-75 
    Details
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les auteurs rapportent l'étude morphologique et ultrastructurale d'un hémangioendothélio-sarcome splénique avec diffusion rapide du processus tumoral au niveau de la moëlle osseuse et du foie. Il existe au sein de la tumeur splénique étudiée une importante activité phagocytaire et surtout érythrophagocytaire des cellules tumorales ainsi que des thromboses multiples. La phase de généralisation est marquée par l'apparition d'une anémie hémolytique, de globules rouges fragmentés, d'une thrombopénie et d'un déficit en facteurs de coagulation. Les thromboses sont responsables de la coagulopathie de consommation. L'anémie hémolytique peut s'expliquer par deux mécanismes associés: l'hémolyse intravasculaire (anémie hémolytique microangiopathique), et, l'érythrophagocytose par les cellules tumorales et le système réticuloendothélial, de globules rouges fragilisés par leur passage dans la tumeur.
    Notes: Summary The authors studied the light and ultrastructural morphology of a malignant hemangioendothelioma of the spleen, which rapidly spread to the liver and bone marrow. An important phagocytic activity, especially erythrophagocytic, of the tumor cells was observed as well as multiple capillary thromboses. The stage of general spread was marked by the appearance of hemolytic anemia, thrombocytopenia, fragmented red blood cells, and a deficit in coagulation factors. The thrombosis was considered to be responsible for the consumption coagulopathy. The hemolytic anemia may be explained by two associated mechanisms: intravascular hemolysis (microangiopathic hemolytic anemia), and erythrophagocytosis by the tumor cells and by the reticuloendothelial system of the red blood cells made fragile by their passage through the tumor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543558
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  • 6
    Electronic Resource
    Electronic Resource
    Myosite ossifiante circonscrite (1969)
    Springer
    Virchows Archiv 348 (1969), S. 16-35 
    Details
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les auteurs rapportent une observation de myosite ossifiante circonscrite primitive chez un homme de 62 ans. Après un bref rappel sur l'aspect histopathologique, ils étudient l'histochimie, l'histoenzymologie et l'ultrastructure des 3 types d'ossification rencontrés dans cette lésion (ossification membraneuse, ossification enchondrale, ossification ostéoblastique). Outre l'importance de la positivité des réactions pour les protéines, il faut souligner celle des M.P.S. acides sulfatés et surtout non sulfatés, de l'activité phosphatasique alcaline, estérasique, déshydrogénasique et leucine-amino-peptidasique, au niveau de la matrice conjonctive ossifiable, l'activité A.T.Pasique étant plus grande au niveau de la zone de minéralisation de l'os. Les conditions d'ossification sont sensiblement identiques à celles de l'os normal, mais l'étude ultrastructurale précise le caractère anormal du collagène du mésenchyme ossifiable: celui-ci est un collagène court dont la période est de 280 à 350 Angstrœms. Ce fait constitue une modification de structure — dont l'origine génétique et familiale possible est évoquée — qui pourrait être l'un des facteurs responsables de l'ossification pathologique.
    Notes: Summary The authors report a study of myositis ossificans circumscripta in a 62 year old man. The histopathology is briefly described; the histochemistry, histoenzymology and ultrastructure of the 3 types of ossification seen in this lesion (membranous, enchondral and osteoblastic ossification), are reported in detail. The reactions for proteins were positive, and especially those for non-sulfated and sulfated acid M.P.S., and for alkaline phosphatase, esterase, dehydrogenase and leucine-aminopeptidase, in the ossifiable connective matrix. The A.T.P.ase activity was much stronger within the mineralized area of the bone. The conditions of the ossification appeared to be normal, but the ultrastructural study revealed an abnormal character of the collagen of the ossifiable mesenchyme. The collagen fiber was short, its period of 280 to 350 Angstroems, indicating a structural modification, which is possibly genetic and familial in origin. Such a factor may account for the pathological ossification.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542833
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  • 7
    Electronic Resource
    Electronic Resource
    Lhermitte-Duclos disease associated with syringomyelia (1996)
    Springer
    Neuroradiology 38 (1996), S. 529-531 
    Details
    ISSN: 1432-1920
    Keywords: Key words Lhermitte-Duclos disease ; Dysplastic gangliocytoma ; Magnetic resonance imaging ; Syringomyelia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 23-year-old man presented with a 2-week history of intracranial hypertension. CT showed a large, nonenhancing cerebellar mass with surrounding calcification and displacement of the fourth ventricle. MRI revealed a septate lesion, with low signal on T1-weighted and high signal on T2-weighted images. The cerebellar tonsils were displaced below the foramen magnum and there was associated syringomyelia. The MRI features were characteristic of Lhermitte-Duclos (LD) disease (dysplastic gangliocytoma) and the diagnosis was confirmed following surgery. In this case, we emphasise the usefulness of MRI in the diagnosis of LD disease and consider the possible pathogenesis of the associated syringomyelia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00626089
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  • 8
    Electronic Resource
    Electronic Resource
    Lhermitte-Duclos disease associated with syringomyelia (1996)
    Springer
    Neuroradiology 38 (1996), S. 529-531 
    Details
    ISSN: 1432-1920
    Keywords: Lhermitte-Duclos disease ; Dysplastic gangliocytoma ; Magnetic resonance imaging ; Syringomyelia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 23-year-old man presented with a 2-week history of intracranial hypertension. CT showed a large, nonenhancing cerebellar mass with surrounding calcification and displacement of the fourth ventricle. MRI revealed a septate lesion, with low signal on T1-weighted and high signal on T2-weighted images. The cerebellar tonsils were displaced below the foramen magnum and there was associated syringomyelia. The MRI features were characteristic of Lhermitte-Duclos (LD) disease (dysplastic gangliocytoma) and the diagnosis was confirmed following surgery. In this case, we emphasise the usefulness of MRI in the diagnosis of LD disease and consider the possible pathogenesis of the associated syringomyelia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00626089
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  • 9
    Electronic Resource
    Electronic Resource
    Aspect ultrastructural des lesions induites au niveau du poumon de souris par le N-nitroso-N-methylurethane (1972)
    Springer
    Journal of cancer research and clinical oncology 77 (1972), S. 279-291 
    Details
    ISSN: 1432-1335
    Keywords: Lung mouse tumors ; Chemical carcinogen ; Ultrastructure ; Pneumocyte II ; Crystalline inclusions ; Interstitial fibrosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The pulmonary tumours induced in Swiss mice by NMUR seem to be constituted for the most part by cells closely related to the granular pneumocytes (pneumocytes II ou B). Other rarer cells, of epithelial bronchiolar aspect, may take part in the proliferation. The ultrastructural study of tumoral cells suggest that their secretory functions are disturbed. The origin of the crystalline intratumoral structures is discussed, as well as their possible relationship with the production of surfactant. The peritumoral areas are characterized by a dense interstitial flbrosis in which the collagen fibers are associated with an elastoid substance.
    Notes: Resumé Les tumeurs pulmonaires induites chez la souris swiss par le NMUR apparaissent essentiellement constituées de cellules apparentées aux pneumocytes granuleux (pneumocytes II ou B). D'autres cellules plus rares, de morphologie épithéliale bronchiolaire peuvent participer á la prolifération. L'étude ultrastructurale des cellules tumorales suggère que leurs fonctions secrétoires sont perturbées. Le mode de formation des structures cristallins intratumorales est discuté, ainsi que leur rapport éventuel avec la production du surfactant. Les territoires péri-tumoraux sont caractérisés par une fibrose interstitielle dense où les fibres de collagène sont associées à uns substance élastoïde.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00283971
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  • 10
    Electronic Resource
    Electronic Resource
    Trophic ulcers in giant incisional hernias-pathogenesis and treatment (1997)
    Springer
    Hernia 1 (1997), S. 71-76 
    Details
    ISSN: 1248-9204
    Keywords: Incisional hernia ; Surgical treatment ; Cutaneous ulcer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The authors define a framework for the classification and pathogenesis of trophic ulcers in giant incisional hernias. These ulcers are the result of ischemic changes; they are always situated at the vertex of the herniation and their presence complicate treatment for they are always infected. The management of the ulcer and of the hernia are two distinct concerns which must be considered separately.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02427665
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