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  • 1990-1994  (10)
  • 1970-1974  (4)
  • 1960-1964
  • 1955-1959
  • 1993  (10)
  • 1971  (4)
  • 1
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 97 (1993), S. 4192-4195 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 97 (1993), S. 4187-4191 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 97 (1993), S. 9736-9740 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 129 (1993), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The presence of human Merkel cells in the eccrine ridges and eccrine germs was studied, using antibodies to simple epithelial keratins, in separated epidermal sheets with attached eccrine ducts. The localization of Merkel cells could be analysed three-dimensionally in the wet, whole-mount of the stained sheets. In the plantar skin of a 12-week-old human fetus, immunoreactive (ir-) Merkel cells were randomly located in the flattened epidermis. In the plantar skin of a 15-week-old human fetus, there was early development of eccrine germs, and Merkel cells were concentrated in eccrine gland ridges. In the plantar skin of a 20-week-old human fetus, eccrine germs were well formed and ir- Merkel cells were located within the developing eccrine ridges and ducts. In the plantar skin of adults, the eccrine concentration of Merkel cells was markedly reduced. Concentration of Merkel cells on the eccrine structures was also observed in the scalp skin of human fetuses. This tendency continued into adult life, although there was a marked reduction in the total number of Merkel cells. These findings suggest that epidermal Merkel cells move down into the eccrine ducts as eccrine germs extend into the mesenchyme. Alternatively, they may develop de novo from the keratinocytes of the eccrine duct. In view of the expression of nerve growth factor receptor in fetal Merkel cells, it is postulated that these eccrine gland Merkel cells play a role in the formation of the periglandular nerve plexus.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 143-147 (Oct. 1993), p. 761-766 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 240 (1971), S. 1-22 
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Nagelzellen, die von den ventralen, apikalen und dorsalen Anteilen der proximalen Matrix gebildet wurden, rückten in axial-distaler Richtung vorwärts, bis sie amproximalen Verhornungspunkte zusammentrafen. Von diesem Punkte an wurden der proximalen Nagelplatte ununterbrochen Zellen von der ventralen und dorsalen Matrix und vom Nagelbett zugefügt. Bald hörte die dorsale Matrix auf, Nagelzellen zu entwickeln und wurde weiter distal in den hinteren Nagelfalz umgewandelt. Mit der differentialen Phasenkontrast-Apparatur von Zeiss-Nomarski konnte man die Teilung der proximalen Nagelplatte in eine ventrale und dorsale Hälfte erkennen. Nächst der Lunula entwickelte das Nagelbett noch eine weitere deutliche Schicht unter der proximalen ventralen Schicht. Elektronmikroskopisch zeigten alle Nagelzellen, ohne Rücksicht auf ihren Ursprung, Verhornung durch Anhäufung von Fibrillen ohne Bildung von Keratohyalinkörnern. Membrane-coating granules (MCG) entstanden in reichlicher Menge. Sie wurden abgestoßen und bildeten die intercellulßre Kittsubstanz. Das abgestoßene Material erweiterte einige der engen Membranspalten, während es gewöhnliche, klaffende (nicht-spezifische) Zellgrenzen verengte und dadurch 150–180 Å weite intercelluläre Zwischenräume bildete, nämlich dieengen Zellverkittungen. Die engen Zellverkittungen stellten den häufigsten Typ der intercellulären Anlagerung dar, wodurch die verhornten Nagelzellen zusammengehalten wurden. Die dicke Zellhülle der verhornten Zellen, nämlich dasGrenzband, wurde durch Niederschlag von dichtem Material an der protoplasmatischen Seite der Zellmembran gebildet und nicht durch die membrane-coating granules.
    Notes: Summary The nail cells produced in the ventral, apical and dorsal portions of the proximal matrix moved in axiodistal direction to meat together at theproximal point of keratinization. The proximal nail plate from this point on was added continuously by the cells from ventral matrix and nail bed. Dorsal matrix soon ceased to produce nail cells and further distally transformed into the posterior nail fold. With Zeiss-Nomarski differential interference contrast equipment, the proximal nail plate could be divided into the ventral and dorsal halves. Near the lunula the nail bed produced one more distinct layer beneath the proximal ventral layer. Electron miscroscopically all nail cells regardless of their origins were seen keratinizing by accretion of tonofibrils without formation of keratohyaline granules. Membrane-coating granules (MGG's) were produced in abundance. They were discharged and provided the intercellular cement. The discharged material widened some of the gap junctions while it tightened nonspeccific junctions to produce 150–180 Å intercellular spaces, i.e. thenarrow junctions. The narrow junctions were the most common type of intercellular junction connecting the keratinized nail cells. The thick cellular envelope of the keratinized cells, i.e. themarginal band, was formed by a precipitation of dense material on the cytoplasmic side of the plasma membranes and not by discharged MCG's.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-069X
    Keywords: Merkel cell ; Bulge ; Arrector pili muscle ; Nerve plexus ; Skin development
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The distribution of Merkel cells in human fetal hair follicles was studied using whole mounts of separated epidermis with attached hair follicles. The technique had the advantage of enabling the elucidation of the spatial relationships of Merkel cells with other cells in the skin. In a 16-week-old fetus the hair anlagen had formed one or two epithelial swellings of variable size. In a 17-week-old fetus sebaceous glands and the bulge of the hair follicle were recognizable and immunoreactive Merkel cells were present in the bulge and surrounding the acrotrichium (intraepidermal follicular canal). In a 20-week-old fetus the sebaceous gland and bulge were well formed and immunoreactive Merkel cells were concentrated in the bulge and infundibulum. In vertical sections of a 20-week-old fetus immunoreactive Merkel cells were also situated in the vicinity of the bulge. Arrector pili muscles were first observable in a 24-week-old fetus being weakly stained with anti-desmin antibody. In a 24-week-old fetus, nerves were also stained within the arrector pili muscles with S-100 protein antibody. In the presumptive arrector pili muscle immunoreactivity for S-100 protein developed before or at the same time as immunoreactivity for desmin. Merkel cells or their products in the bulge may serve as attractants for the growing arrector pili muscle which contain peripheral nerves. Following our report that dermal Merkel cells influence the formation of the dermal nerve plexus, perifollicular Merkel cells near the bulge may also play an inductive and growth-stimulative role for the perifollicular nerve plexus.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 240 (1971), S. 349-364 
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Kleine protoplasmatische Körnchen, welche in verschiedenen verhornenden Epithelien gefunden worden sind und als der Zellmembran aufliegende Körnchen oder Keratinosome bezeichnet wurden, konnten durch Phospholipase C gespalten werden. Körnchen, die in die intercellulären Zwischenräume abgestoßen waren, waren gleichfalls durch Phospholipase C spaltbar. Da angenommen wird, daß Phosphatide einen Teil der intercellularen Kittsubstanz bilden, nicht nur in der Haut, sondern auch in anderen eng zusammengefügten Epithelien, wird die Bezeichnung „Kittkörnchen“ oder „Kittkörper“ für diese Körnchen vorgeschlagen.
    Notes: Summary Small cytoplasmic granules, which have been found in various keratinizing epithelia and called the membrane-coating granules or keratinosomes, were found to be amenable to phospholipase C digestion. Granules discharged into the intercellular spaces could also be digested with phospholipase C. Since it is believed that phospholipids are part of the intercellular cement not only in the skin but in other tightly junctioned epithelia, the name “cement granule” or “cementsome” was proposed for these granules.
    Type of Medium: Electronic Resource
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