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  • 1
    Electronic Resource
    Electronic Resource
    Zur Bestimmung der Methionin-Synthetase in menschlichen Geweben und ihrer biologischen Bedeutung (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 985-985 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Methionin-Synthetase ist ein Schlüsselenzym in der Synthese von Nucleoproteiden. Ein einfaches Verfahren für die routinemäßige Bestimmung wurde in unseren Arbeitskreisen entwickelt. Die Kontrolle dieses Enzyms läßt wichtige Ergebnisse, besonders für die Diagnose und Therapie bösartiger Erkrankungen, erwarten.
    Notes: Summary Methionin synthetase is a key enzyme in nucleoprotein synthesis. A simple method for its routine estimation was developed. Sequential determinations may become an important parameter in cell metabolism, especially in relation to diagnostics and therapy of neoplastic diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01486991
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Demonstration of adenosin 3′,5′-monophosphate dependent protein-phosphokinase in human platelets (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 1114-1115 
    Details
    ISSN: 1432-1440
    Keywords: Platelets ; Cyclic AMP ; Protein-phosphokinases ; Blutplättchen (Mensch) ; c-AMP ; Protein-Phosphokinase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In menschlichen Blutplättchen wurde eine Enzymreaktion gefunden, die die Eigenschaften typischer Proteinkinasen anderer Zellen und Gewebe zeigt: Phosphorylation basischer Proteine (Histon) in Serin- und Threoninresten, Magnesiumabhängigkeit und Stimulation durch Adenosin 3′,5′-monophosphat. Dieses Enzym könnte ein wichtiges Bindeglied zwischen der intracellulären c-AMP-Konzentration und der Plättchen-Funktion darstellen.
    Notes: Summary An enzyme reaction in human platelets is demonstrated which possesses the properties of protein-phosphokinases isolated from other cells: phosphorylation of basic proteins in phosphoserine and -threonine linkages, magnesium dependency and stimulation by adenosine 3′,5′-monophosphate. It is suggested that this enzyme might be responsible for the expression of the cAMP effects on the platelets.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01486857
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Verhandlungen ärztlicher Gesellschaften (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 889-892 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01488949
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Das Proteinmuster der Ductus thoracicus-Lymphe von Normalpersonen und Patienten mit Lebercirrhose (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 86-91 
    Details
    ISSN: 1432-1440
    Keywords: Lymph ; Proteins ; Immunoglobulins ; Isoenzymes ; Peptides ; Lymphe ; Proteine ; Immunglobuline ; Isoenzyme ; Peptide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Proteine aus Ductus thoracicus-Lymphe von 7 Patienten mit Lebercirrhose wurden mit Blutseren derselben Patienten sowie mit Lymph- und Blutseren von Normalpersonen nach Konzentration, elektrophoretischem Verhalten im Polyacrylamidgel, immunologischen Eigenschaften und Enzymgehalt verglichen. Auffallend war in den Lymphseren ein relativ geringer IgM-Gehalt, ein teilweise erhöhter IgA-Gehalt, eine hohe Albuminkonzentration, ein lebertypisches LDH-Isoenzymmuster, in 2 Lymphseren das Vorkommen eines lebereigenen Proteins und in einigen pathologischen Lymphseren das Auftreten eines Glykopeptids in hoher Konzentration.
    Notes: Summary The proteins of the thoracic duct lymph and blood serum from seven patients with liver cirrhosis and from normal persons were characterized by protein determination, electrophoresis on polyacrylamid gel, as well as by immunological and enzymatic methods. Differences between lymph and blood sera were observed. The lymph sera showed a low IgM content, a partially elevated IgA content, high albumin concentration, and altered LDH-isoenzyme pattern. In some lymph sera high concentrations of soluble protein from the liver and a glycopeptide were found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01484815
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    Paper (German National Licenses)
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  • 5
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    Making Sense out of the Terminology of the New Social Studie s (1972)
    Philadelphia : Periodicals Archive Online (PAO)
    Social studies. 63:4 (1972:Apr.) 147 
    Details
    ISSN: 0037-7996
    Topics: History
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:3111-1972-063-04-000002
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  • 6
    Electronic Resource
    Electronic Resource
    Dynamic pressure-flow curves in the autoregulating kidney vasculature of conscious dogs (1972)
    Springer
    Pflügers Archiv 335 (1972), S. 29-45 
    Details
    ISSN: 1432-2013
    Keywords: Blood Flow Velocity ; Renal Artery ; Blood Pressure ; Vessel Distensibility ; Autoregulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In three healthy conscious dogs blood pressure was measured in the abdominal aorta with an implanted miniature transducer. Flow velocity in the left renal artery was recorded by an electromagnetic flowmeter. An appropriate distance between the transducer sites compensated the time-lag introduced by the flowmeter system and allowed records with a negligable foot to foot phase shift between the flow- and the pressure pulse. Pressure-flow curves (I.-P. curves) were obtained recording flow versus pressure beat by beat on an oscilloscope. Electrical stimulation of the right cervical vagus nerve produced I.-P.-curves, which decayed in less than 3 sec down to a blood pressure of 25 mm Hg (dynamic I.-P.-curve). Static I.-P.-curves were recorded by reducing blood pressure within 1 to 2 min to the same pressure level. The following results were obtained: A unique dynamic I.-P.-curve, which follows the power functionI=a·P n exists for each level of arterial mean pressure i.e. “myogenic” vascular tone. An increase of arterial mean pressure (i.e. “myogenic” vascular tone) decreases the exponentn and increases the coefficienta of the power function. The static I. P.-curve, which runs parallel to the pressure axis above 90 mm Hg is actually composed of a family of different dynamic I.-P.-curves. The kidney resistance vessels are rather distensible. The pressure-dependent increase of “myogenic” vascular tone, which developes at perfusion pressures above 55 mm Hg, decreases the vessel distensibility. A change of mean perfusion pressure causes the kidney resistance vessels to shift from one to another dynamic I.-P.-curve without altering mean blood flow.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00586933
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  • 7
    Electronic Resource
    Electronic Resource
    Der Einfluß einer konstanten Herzfrequenz auf den Carotis-Sinus-Reflex am wachen Hund (1972)
    Springer
    Pflügers Archiv 337 (1972), S. 59-70 
    Details
    ISSN: 1432-2013
    Keywords: Pressoreceptors ; Parasympatholytics ; Pacemaker, Artificial ; Cardiac Output ; Vascular Resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In healty, conscious dogs the heart rate was kept constant at 144 to 146 beats per minute either by vagal blockade with Atropine (0,5 mg/kg i.v.) or by electrical pacing of the heart. In the resting dog a carotid-sinus-reflex was elicited clamping both common carotid arteries with implanted pneumatic cuffs. Velocity in the ascending aorta (electromagnetic flowmeter), pressure in the descending thoracic aorta (implanted miniature pressure transducer) and pressure in the right carotid sinus using a catheter were measured. By analogue processing acceleration in the ascending aorta, stroke volume and stroke work of the left ventricle, and mean values were derived. Compared to the reflex under normal resting heart rates (64 beats per minute) the results show, that with a constant heart rate (144–146 beats per minute) blood pressure rises by about the same amount induced by a larger increase of the peripheral resistance. Because the fast increase of cardiac output regularly observed under normal conditions was eliminated, the time course of pressure elevation was slower when heart rate was kept constant. The elevated stroke work of the left ventricle during carotid occlusion cannot be explained by an increase of contractility due to enhanced sympathetic activity, because no such increase in contractility was found. It is suggested, that a low control heart rate allows fast reflex adjustment of blood pressure mediated by increases of cardiac output due to vagal inhibition. In contrast, when heart rate is high due to vagal blockade or electrical pacing, the reflex response is determined by slow changes of the total peripheral resistance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587873
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