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  • 1
    Electronic Resource
    Electronic Resource
    Laser diagnostic in molecular beams (1975)
    Springer
    Applied physics 8 (1975), S. 65-70 
    Details
    ISSN: 1432-0630
    Keywords: Nozzle beams ; Laser Diagnostic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract The output from a stabilized, tunable single-mode laser is split into two beams which cross the molecular beam perpendicularly and at an angle of β to the beam axis. Tuning the laser frequency across the unshifted and Doppler-shifted absorption profile of the molecular transition yileds the velocity distribution of the molecules in the beam for individual quantum states. The internal state distribution among vibrational and rotational levels in the beam can be determined by comparing the fluorescence simultaneously induced in the beam and in a cell with molecules in thermal equilibrium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00883672
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Disposition of β-methyldigoxin in man (1975)
    Springer
    European journal of clinical pharmacology 9 (1975), S. 105-114 
    Details
    ISSN: 1432-1041
    Keywords: Methyldigoxin ; excretion ; deep compartment ; O-demethylation ; glycosides ; metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The time course of radioactivity in plasma and the excretion in urine and faeces over 7 days were determined in 12 healthy subjects after single oral and intravenous doses of a solution of3H-β-methyldigoxin. 62.2±2.1 and 29.0±5.2 per cent of the dose were excreted in urine and faeces, respectively, within 7 days of intravenous administration, compared with 55.2±2.8 and 28.6±5.7 per cent after oral administration. This indicates almost complete absorption of the glycoside when given in solution. 12 hours after its administration a pseudo-distribution equilibrium was reached and the average half life of tritiated compounds was 1.3 days. By 48 – 96 hours after treatment the average half life was 2.8 days. O-demethylation was revealed as the main metabolic degradation step in man. The rate of Demethylation was higher after oral than i.v. administration. Thus, only 31% of the radioactivity excreted in the urine consisted of unchanged β-methyldigoxin after oral administration compared to 51% after i.v. dosing. Only traces of bis- and monoglycosides were excreted in urine, but there were considerable amounts in faeces, where they accounted for more than 35% of the total excretion. Up to 40% of the radioactivity in plasma and urine consisted of polar conjugates during the first 12 hours after administration of β-methyldigoxin. The mono- and bisglycosides were identified as the main products of conjugation. During the 7 days approximately 15% of the administered dose was metabolized by splitting off glycosidic bonds and conjugation to polar compounds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614005
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of phenobarbital, spironolactone and pregnenolone-16α-carbonitrile on bile formation in the rat (1975)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 287 (1975), S. 33-45 
    Details
    ISSN: 1432-1912
    Keywords: Bile Formation ; Lipid Secretion ; Phenobarbital ; Spironolactone ; Pregnenolone-16α-Carbonitrile
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of pretreatment for 4 days with the hepatic microsomal enzyme inducers phenobarbital (8 mg/100 g body weight), spironolactone (20 mg/100 g body weight) and pregnenolone-16α-carbonitrile (7 mg/100 g body weight) on bile flow and bile lipid secretion have been compared in rats. Similar to phenobarbital, spironolactone and pregnenolone-16α-carbonitrile increased bile flow but did not alter bile salt excretion, indicating that these agents increased bile salt independent bile formation. This finding could be substantiated for spironolactone by studies of the relationship between bile salt excretion and bile flow during bile salt infusions. Whereas phenobarbital decreased cholesterol and phospholipid secretion to 39 and 49%, respectively, spironolactone and pregnenolone-16α-carbonitrile more than doubled cholestal excretion without influencing phospholipid output. As a consequence, marked differences in the effect on cholesterol saturation were observed: a decrease by phenobarbital and an increase following spironolactone and pregnenolone-16α-carbonitrile. The present studies demonstrate that different types of enzyme inducers may share certain effects on bile formation and differ in others.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00632636
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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