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  • 1975-1979  (3)
  • 1975  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Effect of diazoxide on left ventricular performance in hypertension (1975)
    Springer
    European journal of clinical pharmacology 8 (1975), S. 387-392 
    Details
    ISSN: 1432-1041
    Keywords: Left ventricular pressure ; left ventricular contractility ; hypertension ; diazoxide ; beta-adrenergic blockade ; isometric exercise
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of diazoxide on left ventricular performance during rest and isometric exercise (handgrip) was examined in 16 unselected hypertensive patients, 6 of whom had been pretreated with the beta-adrenergic blocking agent pindolol. Diazoxide regularly and promptly produced a fall in left ventricular systolic and end diastolic pressures, and an increase in heart rate and left ventricular dp/dtmax. Haemodynamic changes were maximal 2 minutes after injection of the drug and decreased little over the next 8 minutes. After beta-adrenergic blockade, diazoxide caused a more pronounced reduction in left ventricular systolic pressure and a less marked fall in end-diastolic pressure, whilst the diazoxide-induced rise in heart rate was partially and the increase of dp/dtmax was completely inhibited. The increase in systolic pressure during isometric exercise was not influenced by diazoxide, but the positive inotropic reaction was augmented. The findings appear to show that cardiac stimulation by diazoxide is due to a reflex mechanism transmitted by baroreceptors, and that improvement of cardiac performance is mainly due to a reduction of left ventricular after-load.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00562311
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1975)
    Springer
    Journal of molecular medicine 53 (1975), S. 288-291 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01469123
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Kinetik der Chlor-Addition an aliphatische Olefine (1975)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 317 (1975), S. 53-61 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Addition von Chlor an 24 Olefine verschiedener Struktur wurde in Methanol als Lösungsmittel bei etwa -70°C nach der Methode der Konkurrenzreaktion kinetisch untersucht. Um eine radikalische Reaktion auszuschließen, wurde in Gegenwart von Sauerstoff und unter Lichtausschluß gearbeitet.Die relativen Reaktionsgeschwindigkeiten der 22 untersuchten offenkettigen aliphatischen Olefine lassen sich befriedigend mit der dreiparametrigen und der fünfparametrigen TAFT-Gleichung korrelieren, doch deuten die Ergebnisse (ϱ* = -1,29 bzw. ϱ1* = -1,26 und ϱ2* = -1,16) auf einen Übergangszustand, der keine Ähnlichkeit mit einem offenkettigen Carbeniumion besitzt.
    Additional Material: 6 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19753170106
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    Paper (German National Licenses)
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