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  • 1
    Electronic Resource
    Electronic Resource
    Block and Graft Copolymers of Pivalolactone. I. A New Class of Elastoplastics and Thermoplastic Elastomers (1976)
    s.l. : American Chemical Society
    Macromolecules 9 (1976), S. 371-373 
    Details
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ma60050a042
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  • 2
    Electronic Resource
    Electronic Resource
    Chemistry of the polynuclear metal halides. 13. Mixed-metal M6X12n+ species containing both tantalum and molybdenum (1978)
    s.l. : American Chemical Society
    Inorganic chemistry 17 (1978), S. 1867-1872 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic50185a034
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    An ultrastructural study of the effects of x-irradiation on the oral epithelium of the rat: Qualitative aspects (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 5 (1976), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Adult male rats of Simonsen strain were given a dose of 5000 r at 50 peak KV of x-irradiation directed at the lower lip, which was everted through a hole in a lead rubber cylinder shielding the head and body of the animal. Light and electron microscopic observations were made on specimens of lip oral mucosa from animals killed at 2, 6, 26 and 50 h and at 12 days after irradiation. The experimental model met the aim of permitting the study of the sequential effects of a high dose of irradiation without causing ulceration of the mucosa.Widespread degenerative changes were noted in the basal cells as early as 2 h after x-irradiation, increasing in degree up to 50 h. They included inflation of the outer nuclear envelope and rough endoplasmic reticulum (RER) with loss of ribosomes, swelling of mitochondria and disarrangement of cristae evident at 2 h, followed at 6 h by swelling of nucleus and cytoplasm and 26 h by frank membrane breaks. Irreversible degrees of damage were noted in a small though growing minority of cells. Immediate mobilization of the Golgi-lysosomal system was evident as an increase in size of the zone, maximal at 2 h, and subsequent autophagic activity. Signs of recovery, beginning at 26 h, were noted in nuclear envelope, RER, intercellular space, and in mitotic activity by 50 h. Virtually complete recovery was seen at 12 days.It is held that the successful confinement of irradiation to a small tissue volume, the effective activity of the lysosomal system and the short epithelial turnover time were important factors in limiting the damage and in permitting recovery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1976.tb01766.x
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  • 4
    Electronic Resource
    Electronic Resource
    Diffusion through a membrane: Approach to equilibrium (1976)
    Springer
    Bulletin of mathematical biology 38 (1976), S. 527-534 
    Details
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract The transfer of solute through a membrane separating two aqueous solutions is studied with the time-dependent diffusion equation for composite media. By introducing new independent and dependent variables it is shown that the differential equations and boundary conditions can be transformed into a dimensionless form which does not explicitly depend on the diffusivities of the media. Laplace transforms are used to derive explicit solutions for the solute concentration as a function of position and time. It is shown that at large time the concentration approaches the equilibrium distribution exponentially. Explicit results are given for the decay time as a function of the parameters of the system. In addition, an accurate and simplified expression is derived for the decay time for the case of small membrane permeability. The accuracy of the analytic solutions for the concentration profiles is tested by comparing them with numerical results obtained by solving the diffusion equations by the method of finite differences. Excellent agreement is found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02459551
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  • 5
    Electronic Resource
    Electronic Resource
    123. Frühresultate nach 110 aorto-coronaren Venenbypassoperationen (1978)
    Springer
    Langenbeck's archives of surgery 347 (1978), S. 629-630 
    Details
    ISSN: 1435-2451
    Keywords: Surgery, aortocoronary by-pass ; Early results ; Aortocoronarer Venenbypass ; Frühresultate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In einer 12-monatigen Periode wurden 110 Patienten (102 Männer, 8 Frauen) mit einer Frühmortalität von 4,5 % operiert. Zusatzeingriffe: 3 mal Klappenersatz, 7 mal Aneurysmektomie. Einfach-Bypass erhielten 22 Kranke,ohne Mortalität. 43 Patienten hatten Doppelbypass, hier starben 3, und unter 45 Patienten mit 3–5fachem Bypass starben 2. 88 % der Gruppe weist in einer Frühbeobachtungsperiode von 4 Monaten Besserung im Vergleich mit dem präoperativen Zustand auf. Für das Persistieren der Beschwerden werden Bypassverschlüsse, Myokardinsuffizienz und:diffuse Coronarveränderungen verantwortlich gemacht.
    Notes: Summary During a twelve-month period, 110 consecutive patients (102 men, 8 woman) with chronic stable angina were operated upon. Early mortality was 4.5 % in this specific series. Concomitant valve replacement and left-ventricular aneurysmectomy were performed in three (2 AVR, 1 MVR) and seven patients respectively. Of all survivors, 88 % were free of angina within a 4-month follow-up period. Bypass occlusion, congestive heart failure, and diffuse sclerosis were primarily responsible for unsuccessful operative results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01579415
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  • 6
    Electronic Resource
    Electronic Resource
    A rapid and simple method for the isolation of pure eosinophilic leukocytes from horse blood (1978)
    Springer
    Cellular and molecular life sciences 34 (1978), S. 1654-1656 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary An improved and short method is described for the isolation of intact eosinophilic leukocytes from horse blood with high yield (1–1.5 g/20 1). Viability and purity of the preparations were verified by light and electron microscopy and by the trypan blue exclusion test. Isolated eosinophils were 98–100% pure, intact and viable, and they could be shown to phagocytise immune-complexes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02034734
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  • 7
    Electronic Resource
    Electronic Resource
    A thermodynamic analysis of the secondary transition in the spontaneous precipitation of calcium phosphate (1978)
    Springer
    Calcified tissue international 25 (1978), S. 209-216 
    Details
    ISSN: 1432-0827
    Keywords: Thermodynamics ; Kinetics ; Apatite ; Octacalcium phosphate ; Tricalcium phosphate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary A thermodynamic analysis has been made of the secondary transition stage in the spontaneous precipitation of calcium phosphate following the amorphous-crystalline transformation. The first formed crystalline material has a solubility similar to that of octacalcium phosphate (OCP) and the computed thermodynamic solubility product remains invariant in the pH range 7.00–8.60. The duration of the secondary stage is sensitive to pH and the transition appears to occur by hydrolysis of the first formed OCP-like phase to a more basic apatitic phase with a tricalcium phosphate (TCP) stoichiometry. The crystalline material at the end of this transition has an invariant solubility product, in the pH range 7.00 to 8.60, when the TCP-like molecular formula is assumed. Changes in the solution chemistry which accompany the solid-tosolid transitions are consistent with the above conclusions. The results of this study are also consistent with those of a previous study which suggest that the stability of the amorphous calcium phosphate phase is dependent upon the instability of the solution phase with respect to OCP formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02010771
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  • 8
    Electronic Resource
    Electronic Resource
    Distribution of the a blood-group activity in porcine serum (1976)
    Springer
    Cellular and molecular life sciences 32 (1976), S. 929-930 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The A blood-group activity of pig serum is bound to a lipid, in some cases also to a nonlipid fraction. The major lipidic A activity (roughly 50%) is carried with the HDL class, while the VLDL and LDL classes contain roughly 25% each.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02003773
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  • 9
    Electronic Resource
    Electronic Resource
    A thermodynamic analysis of the amorphous to crystalline calcium phosphate transformation (1978)
    Springer
    Calcified tissue international 25 (1978), S. 59-68 
    Details
    ISSN: 1432-0827
    Keywords: Amorphous calcium phosphate ; Thermodynamics ; Apatite ; Octacalcium phosphate ; Tricalcium phosphate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary A thermodynamic analysis of the precipitation of amorphous calcium phosphate (ACP) and its transformation to crystalline apatite has been made. A nearly constant ion product, over a wide variety of conditions, was obtained for a tricalcium phosphate (TCP)-like phase suggesting that the molecular unit which governs the solubility of ACP may be similar in composition to TCP. The introduction of 10% acid phosphate into the formula for the TCP ion product improves the fit of experimental data and results in an invariant ion product. The stability of ACP in solution was found to be dependent upon its thermodynamic instability with respect to an octacalcium phosphate (OCP)-like phase. The dependence of the induction period for the amorphous to crystalline transformation upon the pH and the Ca/P ratio of the solution is best explained by the assumption that an OCP-like phase is initially nucleated on the surfaces of the ACP particles. The events that occur in the immediate post-transition period suggest the hydrolysis of this OCP-like material to an apatitic phase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02010752
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  • 10
    Electronic Resource
    Electronic Resource
    Computersystem für die automatische Analyse von Herzkatheterdaten (1978)
    Springer
    Journal of molecular medicine 56 (1978), S. 81-91 
    Details
    ISSN: 1432-1440
    Keywords: Heart catheterisation ; Cath-lab-systems ; Computer analysis ; Haemodynamic studies ; Man-computer interaction ; Computer reliability ; Herzkatheteruntersuchung ; Herzkatheterlabor ; Computeranalyse ; Hämodynamik ; Mensch-Computer-Dialog ; Computer-Zuverlässigkeit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das in Aachen entwickelte Computersystem für die on-line-Analyse von hämodynamischen Daten ermöglicht im Dialog mit dem Rechner die sofortige Auswertung von Ekg, Drücken und Kälte- bzw. Farbstoffverdünnungskurven. Das Vorgehen bei der Kurvenauswertung sowie die vom Computer angestellten Berechnungen der einzelnen hämodynamischen Parameter werden beschrieben. Bei der Gegenüberstellung der ärztlich-manuellen Auswertung der auf Papier registrierten Druckkurven und der Computerresultate zeigt das in der täglichen Routine seit Oktober 1974 eingesetzte System eine sehr gute Korrelation für die Wellenerkennung und Wellenvermessung. Auch bei Verwendung verschiedener in der Praxis üblicher, flüssigkeitsgefüllter Katheter und des Tip-Manometers bestätigt sich für die Druckregistrierung in den einzelnen Herzabschnitten, daß das Computersystem für alle verwendeten Kathetermaterialien eine zuverlässige Auswertung bringt. Die flexible Konzeption des Computerprogramms mit seiner schnellen Adaptation an neue Fragestellungen erlaubt seinen Einsatz nicht nur in der klinischen Routine sondern besonders bei der Bearbeitung wissenschaftlicher Probleme im Rahmen hämodynamischer Untersuchungen.
    Notes: Summary The computer-system for the on-line-analysis of hemodynamic data developed in Aachen enables the clinical user to perform the immediate on-line analysis of ECG, pressure-curves and thermo- or dye-dilution-curves in a dialog mode. The procedure of pressure analysis as well as the calculations by the computer for the individual haemodynamic parameters are described. The comparison of the medicalmanual evaluation of the pressure curves on paper-registration and the computer results of the same measurement shows a very good correlation for wave-recognitions and wave-measurements for this system, integrated in the daily routine since 24 months. As well in the application of various fluid-filled catheters used in praxis as in tip-manometers it could be proved for the pressure-analysis in the different positions of the heart, that the computer-system produces reliable evaluations for all catheter materials used. The flexible conception of the computer program with its fast adaption to new problems allows its use not only in the clinical routine, but also and especially in the handling of scientific questions in the frame-work of haemodynamic analysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01480088
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