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  • 1
    Electronic Resource
    Electronic Resource
    Die 131-Jod-Hippuranclearance zur Erfassung der nephrotoxischen Wirkung von cis-Dichlorodiamino-Platin (II) (cis-Platin, cis-DDP) (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 561-566 
    Details
    ISSN: 1432-1440
    Keywords: Cis-dichlorodiammine-platinum (II) ; Nephrotoxicity ; Iodo-131-hippurate-clearance ; Serum creatinine ; Creatinine clearance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 25 patients, who received repeated doses of cis-DDP, we determined iodo-131-hippurate-clearance, creatinine clearance and serum creatininc to assess the nephrotoxic effect induced by cis-DDP. A highly significant decrease in the iodo-131-hippurate-clearance was found between the first and the following cycles. There was no significant change in serum creatinine and creatinine clearance however. The radio-hippurate-clearance showed a clinically not important reduction during several cytotoxic courses in 15/25 patients (60%). A clinically relevant impairment of the radio-hippurate-clearance occurred in 8/25 patients (32%), mainly before the third and fifth cytotoxic cycle. In two patients this clearance did not alter or was even rising. In 12 cases a diminuation of the iodo-131-hippurate-clearance was observed, which in only 5 cases correlated to a decreased creatinine clearance and in only two cases to an elevated serum creatinine. Therefore, we consider neither creatinine nor creatinine clearence nor the combination of both parameters to be appropriate to assess tubular nephropathy induced by cis-DDP. Radio-hippurate-clearance should play a superior role deciding on treatment stop or dose reduction of cis-DDP. The regression of cis-DDP-induced nephropathy was not evaluated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01486846
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Improvement of bone scintigraphy by quantitative evaluation compared with X-ray studies and iliac crest biopsy in malignant disease (1983)
    Springer
    European journal of nuclear medicine 8 (1983), S. 342-345 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Bone marrow biopsy of the iliac crest was performed on 268 patients (124♂; 144♀). Of these patients 206 had haematological systemic disorders (HSD) or carcinoma and suspected bone involvement, which was confirmed by biopsy on 66 patients. Bone biopsy was performed not longer than 3 weeks after X-ray examination and bone scintigraphy which, combined, had already raised the suspicion of skeletal involvement in 55% of the 66 patients with skeletal involvement diagnosed by biopsy. Additional quantitative evaluation of the bone scans using bone to soft tissue ratios was able to increase the overall accuracy to 67% in that group. Additional quantitative assessment of the scan yielded considerably more effective bone scintigraphy, particularly in cases with visually normal patterns. Available equipment should therefore be used in scintigraphic bone imaging on a routine basis. It was shown that the various methods of examination, i.e. X-ray, biopsy and scintigraphy with both visual and quantitative evaluation provide their own individual values for the final diagnosis. Therefore, if one of the methods shows a negative result, bone involvement is not excluded and the others should be used for confirmation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253542
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    224. Zur Technik der klinischen segmentalen Pankreastransplantation: Ist die Occlusionsmethode sinnvoll? (1983)
    Springer
    Langenbeck's archives of surgery 361 (1983), S. 752-752 
    Details
    ISSN: 1435-2451
    Keywords: Duct occlusion ; Pancreatic allografting ; Gangocclusion ; Pankreastransplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bisher wurden 12 konsekutive segmentale Pankreastransplantationen bei 11 Patienten durchgeführt, wobei in allen Fällen die Gangocclusion mit Ethibloc angewandt wurde. 5 Pankreastransplantate funktionieren derzeit: 2 Jahre, 1 Jahr, 3 Monate, 2 Monate, 1,5 Monate. Bisher haben wir keinen Hinweis dafür (weder klinisch noch nuklear-medizinisch noch histologisch), daß ein Pankreastransplantat aufgrund einer sekundär induzierten Pankreasfibrose versagte. Wir sehen daher keinen Grund, die Technik der Gangocclusion mit Ethibloc bei der klinischen Pankreastransplantation im Augenblick zu verlassen.
    Notes: Summary Twelve consecutive segmental pancreatic allografts have been performed in 11 patients using the technique of duct obstruction with Ethibloc in all cases. Five pancreatic allografts are currently functioning (2 years, 1 year, 3 months, 2 months, 1.5 months). There is no evidence (neither by clinical observations, nor by scan or histological studies) that a pancreatic allograft failed due to secondary fibrosis. Thus, we will continue to use the technique of Ethibloc occlusion in clinical pancreatic transplantation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01276049
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    Paper (German National Licenses)
    Fulltext
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