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  • 1
    Electronic Resource
    Electronic Resource
    Effect of eicosapentaenoic acid in asthma (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 18 (1988), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The role of arachidonic acid metabolites in the pathogenesis of airway inflammation and clinical asthma is currently unknown. The addition of eicosapentaenoic acid (EPA) to the diet of humans has been shown to generate metabolites that are less potent than their arachidonic acid counterparts. The substitution of EPA for arachidonic acid metabolites in patients might cause a decrease in airway inflammation and an improvement in clinical asthma. We studied the effect of addition of EPA to the diet of twelve asthmatic patients. Standard clinical evaluations and pulmonary function tests were done on weeks 0, 3, 6, 10, 12 and 14. Patients ingested either low-dose EPA (0.1 g/day) or high-dose EPA (4.0 g/day) from weeks 6–14 (total of 8 weeks). There was no difference in clinical status or pulmonary function between groups at the start of the study. There was no change in clinical status or pulmonary function between or within groups at the end of 8 weeks of EPA ingestion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1988.tb02857.x
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  • 2
    Electronic Resource
    Electronic Resource
    Frühveränderungen der Schilddrüsenhormone nach Radiojodtherapie der Hyperthyreose unter Berücksichtigung von Ätiologie und begleitender Medikation (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 386-392 
    Details
    ISSN: 1432-1440
    Keywords: Radioiodine therapy ; Thyroid hormone levels ; Thyroid storm ; β-Blockers ; Glucocorticoides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Radioiodine therapy (RITh) is an effective mode of treatment of different types of hyperthyroidism (immunogenic, IH; nonimmunogenic, NIH). The aim of this study was to evaluate the risk of thyroid storm after RITh. For this purpose a systematic determination of thyroid hormones (TT3, TT4) 5 and if possible 12 days after RITh was performed in 416 patients with borderline or overt hyperthyroidism. Additional antithyroid medication after RITh was necessary in 20 patients. Among the remaining 396 patients 48% had been pretreated with antithyroid drugs because of more severe clinical symptoms. This medication was canceled 10 to 5 days before RITh in all cases. After RITh the mean TT3 and TT4 levels of the subgroups, with and without antithyroid premedication, decreased nearly in parallel course. The whole group of 396 patients presented a significant decrease in TT3 levels with a mean from 1.9 to 1.4 ng/ml. In 18 cases (5%) an increase in TT3 level (≥0.5 ng/ml) was detected without requiring antithyroid therapy. No case of thyroid storm was observed in the entire patient group. TT3 decrease appeared to be more pronounced in patients with higher pretreatment levels. TT4 showed a significant decrease only in case of elevated levels. Posttherapeutic hormone levels were not dependent on the etiology of hyperthyroidism (IH, NIH). The decrease of TT3 levels in the IH group was more pronounced after application of 150 Gy compared with 60 Gy. The additional medication with propranolol (≥60 mg/day) enforced the TT3 decrease. Accompanying glucocorticoid medication had no influence on the hormone levels. From these results we conclude that RITh induces no thyroid storm or pronounced elevated hormone levels, if patients with severe hyperthyroidism are pretreated with thionamides.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01711266
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  • 3
    Electronic Resource
    Electronic Resource
    Palliative treatment of painful osseous metastases in prostate carcinoma with the osteotropic β-emitter rhenium-186-HEDP (1997)
    Springer
    Der Urologe 36 (1997), S. 540-547 
    Details
    ISSN: 1433-0563
    Keywords: Key words Prostate cancer • Painrelief • Bone metastases • Rhenium-186-HEDP • Strontium-89 ; Schlüsselwörter Prostatakarzinom • Schmerzpalliation • Knochenmetastasen •186Rhenium-HEDP •89Strontium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die palliative Schmerzbehandlung bei multiplen, ossären Metastasen des fortgeschrittenen Prostatakarzinoms durch systemische Applikation von 89Strontium ist seit langem eine wichtige Option unter den wenigen verfügbaren Therapiemodalitäten. Als neue Substanz mit erheblichen Vorteilen (kürzere physikalische Halbwertszeit, szintigraphische Darstellbarkeit, günstige Biodistribution) steht jetzt 186Rhenium-HEDP zur Verfügung. Seine klinischen Vorteile liegen in der guten Berechenbarkeit des myelosuppressiven Effekts, so daß die Nebenwirkungen geringer sind und die Therapie früher und häufiger wiederholt werden kann. In der Arbeit wird über 15 Anwendungen von Rhenium-186-HEDP bei Prostatakarzinompatienten im Stadium D mit einer 1,4- bis 2fach höheren als der z. Z. üblichen Standardaktivität berichtet. Die Ansprechrate, gemessen an Schmerzreduktion und verbesserter Mobilität der Patienten, betrug 87 % bei vertretbarem myelosuppressivem Effekt. Die durchschnittliche Dauer des Effekts lag bei 4–6 Wochen. Alle 4 Patienten mit einer Zweittherapie sprachen auch auf diese Behandlung an. Die nuklearmedizinische Schmerztherapie mit 186Rhenium-HEDP stellt ein wirksames und auch in erhöhter „Dosis“ nebenwirkungsarmes Verfahren zur palliativen Therapie schmerzhafter Knochenmetastasen dar.
    Notes: Summary Systemic administration of strontium-89 is an important option for pain relief in advanced prostate carcinoma with multiple osseous metastases. Recently, rhenium-186-HEDP was introduced as a new substance which has important advantages (shorter physical half-life, scintigraphic imaging, dose distribution). The myelosuppressive effect can be estimated more accurately in advance, so that adverse effects can be reduced and the treatment can be repeated after a shorter period of time and more often. Our study comprises 15 treatments with rhenium-186-HEDP in advanced prostate cancer patients using the 1.4- to 2-fold standard dose. The response rate, estimated as reduction in pain and increase in patient mobility, was 87 % with no major myelosuppressive effects. The mean duration of pain relief was 4–6 weeks. All four patients with repeated therapy were also responding to the second treatment. Radionuclide therapy for painful osseous metastases with rhenium-186-HEDP appears to be an effective and, even at higher doses, safe procedure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001200050134
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  • 4
    Electronic Resource
    Electronic Resource
    Intracavitary treatment of intrasellar cystic craniopharyngeomas with 90-Yttrium by trans-sphenoidal approach — a technical note (1995)
    Springer
    Acta neurochirurgica 135 (1995), S. 206-209 
    Details
    ISSN: 0942-0940
    Keywords: Intrasellar cystic craniopharyngeoma ; trans-sphenoidal approach ; intracavitary irradiation ; 90-Yttrium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intracavitary irradiation of intrasellar cystic craniopharyngeomas by stereotactic cyst puncture and injection of radioactive solutions is not yet possible. Therefore we designed a new method sphenoidal approach with only a small bony opening of the sella floor, followed by cyst puncture, exclusion of cyst leakage by Metrizamid injection under x-ray control, injection of Y-90-colloid solution at a dosage wich delivers a radiation of 200 Gy to the cyst wall, and finally tight closure of the puncture site using fibrin glue and gelfoam. This method has been used in three patients with good results (follow-up 12–15 months) and without complications. Even though long-term follow-up is not yet available, our preliminary results suggest that this method will be useful for future
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02187771
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  • 5
    Electronic Resource
    Electronic Resource
    Scintigraphic evidence for cardiac sympathetic dysinnervation in long-term IDDM patients with and without ECG-based autonomic neuropathy (1995)
    Springer
    Diabetologia 38 (1995), S. 1345-1352 
    Details
    ISSN: 1432-0428
    Keywords: Insulin-dependent diabetes mellitus ; metaiodobenzylguanidine ; autonomic neuropathy ; sympathetic dysinnervation ; QT interval
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To analyse the presence and extent of global and regional distributions of cardiac sympathetic dysinnervation in long-term insulin-dependent diabetes mellitus (IDDM) without myocardial perfusion abnormalities (99mTc-methoxy isobutyl isonitrile study), 123I-metaiodobenzylguanidine (123I-MIBG) scintigraphy was performed in two clinically-comparable groups (20 diabetic patients with and 22 diabetic patients without ECG-based cardiac autonomic neuropathy). For comparison nine control subjects without heart disease were investigated. Only six diabetic patients (27%) without and one diabetic patient (5%) with ECG-based autonomic neuropathy were found to have a uniform homogeneous uptake of 123I-MIBG, in contrast to a uniform homogeneous uptake in all control subjects. The uptake of 123I-MIBG in the posterior myocardium of diabetic patients was smaller than in the anterior, lateral and septal myocardium (p〈0.001, p〈0.001, p=0.001). In addition, diabetic patients with cardiac autonomic neuropathy (≥ two of five age-related cardiac reflex tests abnormal) demonstrated a more reduced uptake in the global, lateral and posterior myocardium than diabetic patients without (p〈0.01, p〈0.01, p〈0.001). A correlation between global or regional myocardial 123I-MIBG uptake, however, and duration of diabetes, HbA1c, body mass index or QT interval length was not observed. Our study demonstrates that cardiac sympathetic dysinnervation is common in long-term IDDM even in patients without ECG-based cardiac autonomic neuropathy and that the posterior myocardium is predominantly affected. We conclude that 123I-MIBG scintigraphy is a promising approach to further elucidate the pattern and natural history of myocardial dysinnervation in IDDM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401768
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  • 6
    Electronic Resource
    Electronic Resource
    Scintigraphic evidence for cardiac sympathetic dysinnervation in long-term IDDM patients with and without ECG-based autonomic neuropathy (1995)
    Springer
    Diabetologia 38 (1995), S. 1345-1352 
    Details
    ISSN: 1432-0428
    Keywords: Key words Insulin-dependent diabetes mellitus ; metaiodobenzylguanidine ; autonomic neuropathy ; sympathetic dysinnervation ; QT interval.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To analyse the presence and extent of global and regional distributions of cardiac sympathetic dysinnervation in long-term insulin-dependent diabetes mellitus (IDDM) without myocardial perfusion abnormalities (99 mTc-methoxy isobutyl isonitrile study), 123I-metaiodobenzylguanidine (123I-MIBG) scintigraphy was performed in two clinically-comparable groups (20 diabetic patients with and 22 diabetic patients without ECG-based cardiac autonomic neuropathy). For comparison nine control subjects without heart disease were investigated. Only six diabetic patients (27 %) without and one diabetic patient (5 %) with ECG-based autonomic neuropathy were found to have a uniform homogeneous uptake of 123I-MIBG, in contrast to a uniform homogeneous uptake in all control subjects. The uptake of 123I-MIBG in the posterior myocardium of diabetic patients was smaller than in the anterior, lateral and septal myocardium (p 〈 0.001, p 〈 0.001, p = 0.001). In addition, diabetic patients with cardiac autonomic neuropathy ( ≥ two of five age-related cardiac reflex tests abnormal) demonstrated a more reduced uptake in the global, lateral and posterior myocardium than diabetic patients without (p 〈 0.01, p 〈 0.01, p 〈 0.001). A correlation between global or regional myocardial 123I-MIBG uptake, however, and duration of diabetes, HbA1 c, body mass index or QT interval length was not observed. Our study demonstrates that cardiac sympathetic dysinnervation is common in long-term IDDM even in patients without ECG-based cardiac autonomic neuropathy and that the posterior myocardium is predominantly affected. We conclude that 123I-MIBG scintigraphy is a promising approach to further elucidate the pattern and natural history of myocardial dysinnervation in IDDM. [Diabetologia (1995) 38: 1345–1352]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050433
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  • 7
    Electronic Resource
    Electronic Resource
    Beitrag der Nuklearmedizin zur Diagnostik des Hirntumorrezidivs und der zerebralen Radionekrose (1998)
    Springer
    Der Radiologe 38 (1998), S. 924-929 
    Details
    ISSN: 1432-2102
    Keywords: Schlüsselwörter Hirntumor ; Rezidiv ; FDG-PET ; IMT-SPECT ; Key words Cerebral tumors ; Recurrence ; FDG-PET ; IMT-SPECT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The evaluation of brain tumor recurrence and therapy-induced benign changes following surgery and/or irradiation is a diagnostic challenge for imaging methods based on either morphology (cCT/MRI) or function (SPECT/PET). Current literature and the present data of our own patients demonstrate the diagnostic efficiency of IMT-SPECT and FDG-PET in the detection of recurrence and in-vivo grading. Thirty-nine patients suspected of brain tumor recurrence at follow-up were studied by FDG-PET and IMT-SPECT. Thirty-four of 39 patients showed recurrences; in 12 cases even a change in the grade of malignancy was observed. All high-grade recurrences could be confirmed by either methods. IMT-SPECT showed a higher sensitivity in detecting low-grade tumors at recurrence. In contrast to IMT-SPECT, FDG-PET supports sufficient in-vivo grading. Both methods can be used to differentiate between tumor recurrence and radionecrosis. In conclusion the results of our study demonstrate the efficiency of IMT-SPECT and FDG-PET in confirming recurrences and determining the actual tumor grade.
    Notes: Zusammenfassung Ziel der Studie: Die Beurteilung des Hirntumorrezidivs und der davon differentialdiagnostisch abzugrenzenden posttherapeutisch bedingten benignen Veränderungen nach operativer Resektion und/oder Radiatio stellt eine Herausforderung sowohl für die morphologisch orientierten (cCT/MRT) als auch die funktionell bildgebenden Verfahren (SPECT/PET) dar. Anhand einer Literaturübersicht und der hier vorgestellten Daten des eigenen Patientenguts soll die diagnostische Effizienz von L-3-[123I]Iodo-α-methyltyrosin-SPECT (IMT-SPECT) und [18F]-Fluorodeoxyglucose-PET (FDG-PET) im Rahmen der Rezidivdiagnostik und dem In-vivo Grading primärer Hirntumoren aufgezeigt werden. Patienten: 39 Patienten im Alter zwischen 26 und 67 Jahren, bei denen im Rahmen der Nachsorge der Verdacht auf das Vorliegen eines Tumorrezidivs nach vorangegangener operativer Resektion und/oder Radiatio bestand, wurden zur weiteren Abklärung einer IMT-SPECT- und FDG-PET Diagnostik zugeführt. Bei 34/39 Patienten lag ein Rezidiv vor, in 12 Fällen ein zusätzlicher Grading-Wandel. Mit FDG-PET und IMT-SPECT konnten alle Tumoren höheren Malignitätsgrads nachgewiesen werden. Im Vergleich zu FDG zeigte IMT eine höhere Sensitivität, niedriggradige Rezidive zu bestätigen. FDG-PET ist im Gegensatz zu IMT-SPECT in der Rezidivdiagnostik hinsichtlich des nichtinvasiven Gradings Methode der Wahl. Sowohl die PET als auch die SPECT-Befunde ermöglichten zwischen einem Rezidiv und der Radionekrose zu differenzieren. Bei 2 Patienten führte die nuklearmedizinische Diagnostik zum Nachweis eines Rezidivs, in 1 weiteren Fall wurde eine Radionekrose bestätigt. Diskussion: Zusammenfassend belegen die Ergebnisse insbesondere im Fall unklarer cCT/MRT-Befunde, daß mit der IMT-SPECT in der Rezidivdiagnostik und der FDG-PET bei Verdacht auf einen Grading-Wandel entscheidende diagnostische Zusatzinformationen gewonnen werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001170050443
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  • 8
    Electronic Resource
    Electronic Resource
    Functional results of radioiodine therapy with a 300-GY absorbed dose in Graves' disease (1993)
    Springer
    European journal of nuclear medicine 20 (1993), S. 1051-1055 
    Details
    ISSN: 1619-7089
    Keywords: Radioiodine therapy ; Graves' disease ; Thyroid ablation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this study was to assess the results of high-dose radioiodine therapy given to 43 patients with recurrent hyperthyroidism due to Graves' disease between 1986 and 1992. We chose an intrathyroidal absorbed dose of 300 Gy and determined the applied activity individually, which ranged from 240 to 3120 MBq with a median of 752 MBq. Hyperthyroidism was eliminated in 86% of cases after 3 months and in 100% after 12 months. No patient required a second radioiodine treatment. The incidence of hypothyroidism was 63% after 3 months and 93% after 18 months. Neither the pretherapeutic thyroid-stimulating immunoglobulin level nor the degree of co-existing endocrine ophthalmopathy was correlated with the time at which hypothyroidism developed. Patients with previous radioiodine therapy developed hypothyroidism earlier than patients with previous thyroid surgery. The results show that ablative radioiodine therapy with a 300-Gy absorbed dose is a very effective treatment of hyperthyroidism in Graves' disease, but it should be restricted to patients with recurrent hyperthyroidism combined with severe co-existing disorders or episodes of unfavourable reactions to antithyroid drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00173482
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  • 9
    Electronic Resource
    Electronic Resource
    Improvement of bone scintigraphy by quantitative evaluation compared with X-ray studies and iliac crest biopsy in malignant disease (1983)
    Springer
    European journal of nuclear medicine 8 (1983), S. 342-345 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Bone marrow biopsy of the iliac crest was performed on 268 patients (124♂; 144♀). Of these patients 206 had haematological systemic disorders (HSD) or carcinoma and suspected bone involvement, which was confirmed by biopsy on 66 patients. Bone biopsy was performed not longer than 3 weeks after X-ray examination and bone scintigraphy which, combined, had already raised the suspicion of skeletal involvement in 55% of the 66 patients with skeletal involvement diagnosed by biopsy. Additional quantitative evaluation of the bone scans using bone to soft tissue ratios was able to increase the overall accuracy to 67% in that group. Additional quantitative assessment of the scan yielded considerably more effective bone scintigraphy, particularly in cases with visually normal patterns. Available equipment should therefore be used in scintigraphic bone imaging on a routine basis. It was shown that the various methods of examination, i.e. X-ray, biopsy and scintigraphy with both visual and quantitative evaluation provide their own individual values for the final diagnosis. Therefore, if one of the methods shows a negative result, bone involvement is not excluded and the others should be used for confirmation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253542
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