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  • 1
    Electronic Resource
    Electronic Resource
    Thermal stability of WSix/GaAs interface (1987)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 61 (1987), S. 220-224 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Secondary ion mass spectrometry (SIMS), Rutherford backscattering spectrometry (RBS), and measurements of forward current-voltage characteristics at various temperatures were used to study metallurgical reactions in WSix/GaAs formed by sputter deposition. Both SIMS and RBS showed that annealing at 800 °C results in migration of W and Si into GaAs when the atomic ratio x deviates from 0.5. On the other hand, the forward current-voltage characteristics of WSix/GaAs diodes at various temperatures showed that the excess current across the interface induced after annealing is large when x deviates substantially from 0.5, in agreement with the SIMS and RBS results. It is suggested that the migration of W and Si is directly involved in the thermal degradation of the structural and electrical properties of the WSix/GaAs interface and its x dependence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.338860
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  • 2
    Electronic Resource
    Electronic Resource
    Zn-induced impurity levels in layer semiconductor InSe (1989)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 66 (1989), S. 3647-3650 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The impurity levels in Zn-doped InSe have been investigated by photoluminescence (PL), Hall effect (HE), and deep-level transient spectroscopy (DLTS). Previous analysis by PL spectra shows that the radiative transition is dominated by donor-Zn acceptor pairs. In the present work, a search was made for the deep acceptor level using the combined data from HE and DLTS measurements. We find that the deep acceptor level, which is associated with defects or defect complexes formed by Zn atoms in the interlayer, is located about 0.6 eV above the valence band.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.344075
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of diltiazem on the pharmacokinetics of propranolol, metoprolol and atenolol (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 67-70 
    Details
    ISSN: 1432-1041
    Keywords: diltiazem ; propranolol ; metoprolol ; atenolol ; pharmacokinetics ; drug interaction ; beta-adrenoceptor blockade ; healthy volunteers ; pharmacodynamic effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetic interaction between diltiazem and three β-adrenoceptor blockers propranolol, metoprolol and atenolol was investigated in healthy volunteers given diltiazem 30 mg or placebo t.d.s. for 3 days, followed by a single dose of propranolol 20 mg, metoprolol 40 mg or atenolol 50 mg. The AUCs of propranolol and metoprolol were significantly increased after diltiazem and it significantly prolonged the elimination half-life of metoprolol. In contrast, it did not significantly affect the pharmacokinetics of atenolol. Propranolol significantly decreased the resting pulse rate after diltiazem pretreatment as compared to placebo. The results indicate that diltiazem impaired the clearance of propranolol and metoprolol, which are principally metabolized by an oxidative pathway, and that the kinetic interaction between diltiazem and propranolol may partly be related to the significant reduction in the pulse rate produced by the latter.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561026
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  • 4
    Electronic Resource
    Electronic Resource
    Treatment of acute subdural hematoma with a low GCS score (1989)
    Springer
    Neurosurgical review 12 (1989), S. 198-200 
    Details
    ISSN: 1437-2320
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01790648
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of retinoic acid on the replication of human immunodeficiency virus in HTLV-I-positive MT-4 cells (1987)
    Springer
    Medical microbiology and immunology 176 (1987), S. 189-198 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The inhibitory effect of all-trans-retinoic acid (RA) on human immunodeficiency virus (HIV) replication upon infection was studied quantitatively using a novel bioassay system with a HTLV-I-carrying human T-cell line, MT-4. The results can be summarized as follows. (1) The appearance of HIV antigen was significantly reduced when the cells were treated with more than 1 μg/ml of the chemical after infection. When HIV specific plaque assay was performed to titrate the virus from the supernatant of culture treated with 10 μg/ml of RA no plaques were observed. (2) When RA was applied directly in the plaque assay, significant decrease of the number of plaques was discerned showing 68, 66, 47 and 16, at doses of 0.1, 1, 5, and 10 μg/ml of RA, while 102 plaques were formed in the control dish. (3) The appearance of cytopathic effects of MT-4 cells by HIV was more delayed in RA-treated cultures than in untreated cultures. (4) Concomitant treatment of the cells with 5 μg/ml of RA and various concentrations of suramin resulted in the more effective inhibition of HIV replication than suramin alone. (5) RA did not inhibit the reverse transcriptase activity (RT) of HIV directly. These data suggest that RA inhibits HIV replication by inducing an antiviral state in the cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00196686
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  • 6
    Electronic Resource
    Electronic Resource
    Antiretroviral activity in a marine red alga: reverse transcriptase inhibition by an aqueous extract of Schizymenia pacifica (1987)
    Springer
    Journal of cancer research and clinical oncology 113 (1987), S. 413-416 
    Details
    ISSN: 1432-1335
    Keywords: Antiretroviral activity ; Marine algae ; Avian myeloblastosis virus ; Reverse transcriptase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An aqueous extract from the marine red alga, Schizymenia pacifica has been tested in a cell free system for its effect on reverse transcriptase from avian retrovirus (avian myeloblastosis virus), and mammalian retrovirus (Rauscher murine leukemia virus). The extract inhibited reverse transcriptase from both these retroviruses but showed almost no effect, if any, on the activity of cellular DNA polymerase alpha and RNA polymerase II in vitro. Consequently it is unlikely to have an adverse effect on the growth of cultured cell. The inhibitory activity of the extract was stable over a relatively wide pH range (pH 1–11) and was not lost after pronase digestion. Inhibitory activity of the extract was lost after boiling at 100°C in 0.67 N HCl, and after treatment with 100 mM NaIO4. The active principle in the extract has an apparent molecular weight in excess of 100 000 daltons. This new reverse transcriptase inhibitor is probably a polysaccharide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390034
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  • 7
    Electronic Resource
    Electronic Resource
    The outcome of severe head injuries in children (1989)
    Springer
    Neurosurgical review 12 (1989), S. 436-440 
    Details
    ISSN: 1437-2320
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01790687
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