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  • 1985-1989  (19)
  • 1920-1924
  • 1987  (19)
  • 1
    Electronic Resource
    Electronic Resource
    Effect of divalent cations on the potassium contracture of slow muscle fibers ofRana temporaria (1987)
    Springer
    The journal of membrane biology 100 (1987), S. 215-220 
    Details
    ISSN: 1432-1424
    Keywords: slow muscle fiber ; K contracture ; divalent cations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary K contractures of single slow muscle fibers ofRana temporaria were measured isometrically in the presence of normal, reduced, and increased Ca2+ concentrations at 18 to 20°C. At normal Ca2+ concentration (1.8mm) contracture tension decreased from its peak value of 35.4±8.2 N/cm2 to 59.4±23.9% within one minute, and to 48.3±27% within two minutes (30 fibers). Peak tension was virtually unaffected by changes of the Ca2+ concentration, but maintenance of tension was impaired by low (0.2mm), and improved by high (10mm) Ca2+ concentrations. When Ca2+ was added during the K contracture, there was practically no restoration of lost tension. Effects similar to those of Ca2+ were observed upon addition of foreign divalent cations to the medium. Co2+, Ni2+, and Cd2+ were slightly more effective than Ca2+ and Mn2+; the smallest effects were obtained with Mg2+, Sr2+, and Ba2+. The effects of foreign divalent cations were independent of the presence of Ca2+. It is concluded that in slow fibers ofRana temporaria maintenance of contracture tension is not due to an influx of Ca2+ ions. Instead, binding of divalent cations to superficial sites seems to be essential.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02209152
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  • 2
    Electronic Resource
    Electronic Resource
    D600 prolongs inactivation of the contractile system in frog twitch fibres (1987)
    Springer
    Pflügers Archiv 410 (1987), S. 75-82 
    Details
    ISSN: 1432-2013
    Keywords: Twitch fibre ; K-contracture ; Inactivation ; D600
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract (1) Single twitch fibres were dissected from tibialis muscles ofRana temporaria and used to study the effect of D600 (gallopamil) on potassium-induced contractures. (2) 95 mM K-Ringer's was applied for 8–15 s at intervals of generally 2.5–5 min; at temperatures of 6–8°C and in the absence of D600 the amplitude of the contractures remained fairly constant. After pretreatment with D600 (30 μM) a single (conditioning) K-contracture was sufficient to ‘paralyze’ the fibres (cf. Eisenberg et al. 1983). (3) Complete paralysis could also be achieved at 18–20°C. In three fibres a single conditioning K-application was sufficient; in two more fibres two or three conditioning K-applications were required. (4) D600-paralysis could not only be achieved with high K-concentrations but also by conditioning with subor suprathreshold K-concentrations (20–40 mM); the duration of the conditioning periods required to induce complete paralysis was approximately the same before and after D600-treatment. (5) Contractures were partially abolished by application of 20–40 mM K-Ringer's for short conditioning periods; after D600-treatment the degree of contracture loss was similar. (6) At low temperature the state of partial or complete paralysis induced by subthreshold K-concentrations and D600 was maintained for long periods of time. (7) The presence of 10 mM Ca2+ did not protect the fibres from being paralyzed by treatment with D600 and high K-Ringer's at low temperature; however, more than one conditioning K-application was required. (8) Resting and action potentials of paralyzed fibres were not significantly different from control values. However, endplate potentials were reduced in size, and failure of neuromuscular transmission was observed in some of these fibres. (9) It is concluded that D600 prolongs the state of inactivation of the contractile mechanism, while the development of inactivation does not seem to be markedly affected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00581899
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  • 3
    Electronic Resource
    Electronic Resource
    Radiological findings in patients with mucopolysaccharidosis I H/S (Hurler-Scheie syndrome) (1987)
    Springer
    Pediatric radiology 17 (1987), S. 409-414 
    Details
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The development of radiological changes in two patients with mucopolysaccharidosis (MPS) Type I H/S is described. Radiological findings reveal enlargement of the sella in one patient, impression of the basilar skull in the other patient. Sclerosis and thickening of the base of skull was observed in both patients. The mandibular necks were short with striking flattening of the superior surfaces of the condyles, when the patients reached adult age. At the age of 12, hypertelorism and spaced teeth were already present in both patients. In addition, they showed early costal, clavicular and scapular changes, irregularities of the acromial joints and acetabulae, hypoplasia of the inferior portion of the iliac bones and flared iliac wings. The flat femurs had short metaphyses and were held in valgus position. Development of dentigerous cysts as well as mandibular changes seem to be rather specific for this variant ofα-L-iduronidase deficiency. In contrast to the classical form of MPS I, skeletal changes of the spine and hands are minimal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02396619
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  • 4
    Electronic Resource
    Electronic Resource
    Identification of a lys2 mutant of Candida maltosa by means of transformation (1987)
    Springer
    Current genetics 11 (1987), S. 385-391 
    Details
    ISSN: 1432-0983
    Keywords: Candida maltosa ; Transformation ; LYS2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary We have isolated five mutants of Candida maltos, which lack the 2-aminoadipate reductase activity, an enzyme involved in the lysine biosynthesis. By means of complementation analysis using protoplast fusion, the isolated mutants were divided into two complementation groups. Thereof the C. maltosa strain G457 could be transformed by the plasmids pDP12 and pDP13, which contain the L YS2-coding gene of Saccharomyces cerevisiae. On the basis of our presented results obtained by studies on hybridization, stability, and recovery of plasmids from C. maltosa transformants, we suggest that transformation does proceed integratively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00378181
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  • 5
    Electronic Resource
    Electronic Resource
    Continuation vs discontinuation of low-phenylalanine diet in PKU adolescents (1987)
    Springer
    European journal of pediatrics 146 (1987), S. A17 
    Details
    ISSN: 1432-1076
    Keywords: Phenylketonuria ; Adolescents ; Dietary control ; Intelligence ; Psychological problems
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442050
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  • 6
    Electronic Resource
    Electronic Resource
    Successful bone marrow transplantation from an unrelated donor in a child with AML in second remission (1987)
    Springer
    Annals of hematology 55 (1987), S. 199-204 
    Details
    ISSN: 1432-0584
    Keywords: Bone Marrow transplantation ; unrelated mismatched donor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In February 1986 we transplanted a 10-year-old girl with AML in second remission with the bone marrow of an unrelated donor. HLA-types were different for one A- and one B-antigen between patient and donor. Conditioning regimen consisted of 14 Gy total body irradiation with lung shielding, 8×3 g/m2 cytosin arabinoside and 90 mg/kg cyclophosphamide. GVHD-prophylaxis was performed with cyclosporin A, methotrexate and prednisolone. Only mild GVHD I of the skin could be observed after rapid engraftment. 100 days after transplantation the patient was in good clinical condition and GVHD-prophylaxis was discontinued without any reactivation of acute or chronic GVHD. Engraftment was documented by sex chromosome and blood group typing. 120 days after transplantation leukemic blasts were detected in the peripheral blood and the child died 130 days after BMT from relapse of the leukemia. Despite the negative outcome, this was the first successful bone marrow transplantation from a unrelated donor in Germany.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320090
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  • 7
    Electronic Resource
    Electronic Resource
    Tunneling and point-contact spectroscopy of high-T c superconductors M−Ba2Cu3O7 (M=Y, La, Eu) (1987)
    Springer
    The European physical journal 69 (1987), S. 173-178 
    Details
    ISSN: 1434-6036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Tunneling and point-contact measurements have been performed on different high-T c superconductors M−Ba2Cu3O7 with M=Y, La, Eu. The average energy gaps deduced from the tunneling spectra are about 2Δ=33 meV for the Y- and La-type samples and about 2Δ=38 meV for the Eu-type samples, which give ratios 2Δ/k B T c in the range from 4 to 6. The point-contact characteristics show a distinct minimum in the differential resistance about zero bias and additional sharp spikes up to 40 mV. From these pointcontacts we can give an estimate of the critical current, yielding values in the range from 0.2 to 3 mA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01307273
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  • 8
    Electronic Resource
    Electronic Resource
    Rate equations for the dynamics of mixed valence ions (1987)
    Springer
    The European physical journal 65 (1987), S. 305-311 
    Details
    ISSN: 1434-6036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The high temperature dynamics of mixed valent 4f-shells is studied by means of rate equations. Symmetries and detailed balance considerably reduce the number of independent rates. Rates are calculated by Fermi's golden rule. The approach presented here provides an elementary and transparent reproduction of results previously obtained using Mori's formalism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01303716
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  • 9
    Electronic Resource
    Electronic Resource
    Two-photon excited parametric emission from sodium atoms (1987)
    Springer
    Applied physics 44 (1987), S. 41-44 
    Details
    ISSN: 1432-0649
    Keywords: 42.65 Cq
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Tunable coherent radiation around 840, 830, and 795 nm has been generated upon two-photon excitation of sodium 4d and 5s levels, respectively. The generation is due to special parametric processes. A molecular nature of the emissions, as recently proposed, can be ruled out by the performed investigations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00693982
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  • 10
    Electronic Resource
    Electronic Resource
    Human immunodeficiency virus infection is prevalent in Malawi (1987)
    Springer
    Infection 15 (1987), S. 363-363 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01647741
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