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  • 1
    ISSN: 1432-1041
    Keywords: Ipsapirone ; CRF ; ACTH ; cortisol ; time series analysis ; hypothalamic-pituitary-adrenal axis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The neuroendocrine effects (changes in plasma CRF, ACTH and cortisol) of single and multiple (t.d.s. for 2 days) doses of ipsapirone (BAY Q 7821) 5 and 10 mg have been investigated in 6 healthy male volunteers. The study followed a balanced complete block, placebo-controlled and double blind design with two baseline phases (pre and post-treatment). Volunteers were investigated on identical days during 5 successive weeks. The results do not show a specific effect of ipsapirone on the hypothalamic-pituitary-adrenal axis when doses in the range of 5–30 mg per day were given.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-072X
    Keywords: Archaebacteria ; methanogenesis ; energy conservation ; membranes ; F420-dependent hydrogenase ; Methanosarcina
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The distribution of the F420-reactive and F420-nonreactive hydrogenases from the methylotrophic Methanosarcina strain Gö1 indicated a membrane association of the F420-nonreactive enzyme. The membrane-bound F420-nonreactive hydrogenase was purified 42-fold to electrophoretic homogeneity with a yield of 26.7%. The enzyme had a specific activity of 359 μmol H2 oxidized · min-1 · mg protein-1. The purification procedure involved dispersion of the membrane fraction with the detergent Chaps followed by anion exchange, hydrophobic and hydroxylapatite chromatography. The aerobically prepared enzyme had to be reactivated anaerobically. Maximal activity was observed at 80°C. The molecular mass as determined by native gel electrophoresis and gel filtration was 77000 and 79000, respectively. SDS gel electrophoresis revealed two polypeptides with molecular masses of 60000 and 40000 indicating a 1:1 stoichiometry. The purified enzyme contained 13.3 mol S2-, 15.1 mol Fe and 0.8 mol Ni/mol enzyme. Flavins were not detected. The amino acid sequence of the N-termini of the subunits showed a higher degree of homology to cubacterial uptake-hydrogenases than to F420-dependent hydrogenases from other methanogenic bacteria. The physiological function of the F420-nonreactive hydrogenase from Methanosarcina strain Gö1 is discussed.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Acta Polymerica 43 (1992), S. 151-158 
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Measurement methods that are applicable for the characterization of porous structures, i.e. differential scanning calorimetry, low-temperature gas adsorption, mercury high pressure porosimetry, electron and light microscopy, X-ray small angle scattering, water retention value, and apparent density, are described with respect of the peculiarities of poly(acrylonitrile) fibres. The methods have been applied on differently stretched and thermally treated PAN fibres in the gel state and after dehydration, respectively. The observed effects are explained by the different stabilities of the gel fibre structure.
    Notes: Die zur Charakterisierung von Porenstrukturen anwendbaren Meßmethoden Differential-Scanning-Calorimetrie, Tieftemperatur-Gasadsorption, Quecksilber-Hochdruckporosimetrie, Elektronen- und Lichtmikroskopie, Röntgenkleinwinkelstreuung sowie Wasserrückhaltevermögen und scheinbare Dichte werden unter Berücksichtigung der Besonderheiten von Polyacrylnitrilfasern vorgestellt. Die genannten Methoden wurden auf unterschiedlich gereckte und thermisch behandelte PAN-Fasern im Gelzustand und nach Entwässerung angewendet. Die dabei auftretenden Effekte werden mit der unterschiedlichen Stabilität der Gelfaserstruktur erklärt.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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