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  • 1
    Electronic Resource
    Electronic Resource
    Short stature and gestational diabetes in Brazil (2000)
    Springer
    Diabetologia 43 (2000), S. 848-851 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Gestational diabetes, pregnancy, stature, obesity, risk factors, undernourishment.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. To examine the association between maternal stature and gestational diabetes mellitus.¶Methods. We studied a sample of 5564 consecutive Brazilian women 20 or more years old, who were pregnant for approximately 21–28 weeks, had no history of diabetes outside pregnancy and were attending general prenatal care units in six state capitals in Brazil from 1991 to 1995. We did a 2-h, 75-g oral glucose tolerance test, defining gestational diabetes by World Health Organisation criteria.¶Results. Those in the shortest quartile of height ( ≤ 151 cm) had a 60 % increase in the odds of having gestational diabetes, independently of prenatal clinic, age, global obesity, family history of diabetes, skin colour, referral pattern, waist circumference, parity, previous gestational diabetes, education, ambient temperature and gestational age compared with the tallest quartile [odds ratio (OR) = 1.60, p = 0.005]. This association was observed for those with above median values of skinfold thickness (OR = 1.74, p = 0.006) but not for those with below median values (OR = 1.22, p = 0.51). Associations of short stature with high 2-h glycaemia ( ≥ 7.8 mmol/l) (OR = 1.61, p = 0.005) were essentially the same as those for gestational diabetes. There was, however, no association between short stature and gestational hyperglycaemia when the latter was defined exclusively by fasting values (OR = 0.97, p = 0.90).¶Conclusion/interpretation. In Brazil short stature associates with gestational diabetes, principally in women with greater fat mass. This difference in glycaemic levels is present postprandially but not in the fasting state. [Diabetologia (2000) 43: 848–851]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051460
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  • 2
    Electronic Resource
    Electronic Resource
    Computed tomography during arterial portography under temporary balloon occlusion of the hepatic artery: evaluation of pseudolesions caused by arterio-portal venous shunts (2000)
    Springer
    Abdominal imaging 25 (2000), S. 583-586 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Computed tomography during arterial portography (CTAP)—Arterioportal venous shunts—Hepatocellular carcinoma—Pseudolesion—Balloon occlusion—Hepatic artery.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Computed tomography during arterial portography (CTAP) under temporary balloon occlusion of the hepatic artery (BOHA-CTAP) was introduced to evaluate pseudolesions caused by portal venous impairments such as arterioportal shunt and tumor thrombus. Methods: BOHA-CTAP was performed in seven patients with hepatocellular carcinoma and correlated with clinical outcomes. For patients with wedge-shaped defects suggestive of pseudolesions, BOHA-CTAP was obtained by a 5-F balloon occlusion catheter into the proper hepatic artery through the second 5-F introducer inserted into the common femoral artery a few centimeters below the first 5-F sheath for CTAP. Results: Eight pseudolesions were determined clinically on follow-up CT, ultrasonography, or magnetic resonance imagings. On BOHA-CTAP, five of the eight pseudolesions were eliminated, and two were diminished in comparision with conventional CTAP. One wedge-shaped defect due to tumor thrombus in the portal vein did not show any change. Conclusion: BOHA-CTAP can reduce pseudolesions caused by portal venous impairments and enable the demarcation of the true tumors. RID="" ID="" 〈E5〉Correspondence to:〈/E5〉 J. Koizumi
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/s0026110000048
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  • 3
    Electronic Resource
    Electronic Resource
    Interleukins in Churg-Strauss syndrome [IL-13 and ] (2000)
    Copenhagen : Munksgaard International Publishers
    Allergy 55 (2000), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.2000.00720.x
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  • 4
    Electronic Resource
    Electronic Resource
    Development of squamous cell carcinoma by two high-risk human papillomaviruses (HPVs), a novel HPV-67 and HPV-31 from bowenoid papulosis (2000)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 143 (2000), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report a patient with bowenoid papulosis (BP) involving two high-risk human papillomaviruses (HPVs) and the development of invasive squamous cell carcinoma (SCC). Our patient showed verrucous lesions on the penis, perianal area and groin that had been noted over the previous 8 years and had recurred after all therapeutic approaches. The perianal and left inguinal lesions revealed invasive SCC on histology. HPV-31 and HPV-67 sequences were detected by polymerase chain reaction from BP lesions of the perianal area and the shaft of the penis. HPV-31 has already been reported in BP as a high-risk HPV for the development of SCC, but HPV-67 is a novel one that has never been reported in BP. As HPV-67 has sequence homology to HPV-52 and HPV-58, it belongs to the family of HPV-16, a high-risk HPV group. Thus our patient showed two high-risk HPVs, i.e. HPV-31 and the novel HPV-67, which may be directly involved in the development of SCC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2000.03718.x
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  • 5
    Electronic Resource
    Electronic Resource
    The bisphosphonate incadronate for bone metastases of breast cancer (2000)
    Springer
    International journal of clinical oncology 5 (2000), S. 241-246 
    Details
    ISSN: 1437-7772
    Keywords: Key words Bisphosphonate ; Breast cancer ; Bone metastasis ; Bone Metabolic markers ; Tumor marker
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. Bisphosphonates are bone resorption inhibitors which are effective in the treatment of diseases of increased bone turnover, such as hypercalcemia of malignancy and osteolytic bone metastasis. The safety and efficacy of incadronate, a third-generation bisphosphonate, were evaluated in breast cancer patients with bone metastases. Methods. Fifteen breast cancer patients with bone metastasis were enrolled. Incadronate's safety, its effectiveness in relieving bone pain, and its effects on bone metabolic markers and a tumor marker were assessed in 8 patients treated with a 10-mg IV infusion once a week for 5 weeks (10 mg × 5), 3 patients treated with a single 20-mg IV infusion (20 mg × 1), and 4 patients treated with a 20-mg IV infusion once a week for 5 weeks (20 mg × 5). Pain assessment was performed only in the patients with the repeated infusion regimens. Results. All incadronate treatment regimens were administered without any serious adverse reactions. Minimal fever was noted in 6 patients, but it subsided without any treatment. Incadronate relieved bone pain in 10 of the 12 patients who received repeated infusions. Levels of bone resorption markers dropped transiently, but the decreases in the individual markers of bone resorption varied. Levels of bone formation markers did not change significantly. Levels of a tumor marker specific to breast cancer, carbohydrate antigen (CA)15-3 decreased in patients whose metastases were limited to bone. Conclusion. The third-generation bisphosphonate, incadronate, was administered safely at dosages of up to 20 mg once a week for 5 weeks. Incadronate reduced bone pain, bone resorption marker levels, and CA15-3 tumor marker levels in breast cancer patients with bone metastases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00012044
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  • 6
    Electronic Resource
    Electronic Resource
    Familial amyloidotic polyneuropathy (ATTR Ser50Ile): the first autopsy case report (2000)
    Springer
    Virchows Archiv 436 (2000), S. 345-350 
    Details
    ISSN: 1432-2307
    Keywords: Key words Amyloidosis ; ATTR Ser50Ile ; Autopsy ; Familial amyloidotic polyneuropathy ; Transthyretin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We report an autopsy case of a pedigree of familial amyloidotic polyneuropathy (FAP) with a mutation of isoleucine-50 transthyretin (ATTR Ser50Ile). A 47-year-old man started developing severe diarrhea and weight loss at age 41 years, followed by urinary incontinence, autonomic-nervous-system abnormalities and serious heart failure; the diagnosis of FAP (ATTR Ser50Ile) was made on the basis of genetic, histochemical and immunohistochemical analysis. Six years after the initial symptoms, he died of septic shock. Autopsy revealed suppurative peritonitis, perforation of the sigmoid colon and marked systemic amyloid deposition. The total amount of amyloid deposited in the heart was greatly increased and was much lower in the thyroid gland and kidneys compared with amyloid deposits in ordinary FAP (ATTR Val30Met). Amyloid deposition in peripheral vessel walls was prominent, particularly in lymphatics and veins. His elder sister, 54 years old, started to develop orthostatic hypotension at age 49 years, followed by dysesthesia, diarrhea and severe congestive heart failure. Endomyocardial biopsy revealed severe TTR–amyloid deposition; ultrastructural examination demonstrated that amyloid fibrils were deposited disproportionately and extended radially around microvessels. These characteristic patterns of systemic amyloid deposition and distinct clinical manifestations, especially in the cardiovascular system, are considered to be a characteristic feature of ATTR Ser50Ile amyloidosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050457
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  • 7
    Electronic Resource
    Electronic Resource
    Influence of particle diameter on the morphology of micron-sized, monodispersed composite polymer particles produced by seeded polymerization for the dispersion of highly monomer-swollen polymer particles (2000)
    Springer
    Colloid & polymer science 278 (2000), S. 1007-1013 
    Details
    ISSN: 1435-1536
    Keywords: Key words Dynamic swelling method ; Morphology ; Micron size ; Seeded polymerization ; Composite polymer particle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract  Micron-sized, monodispersed polystyrene (PS)/poly (n-butyl methacrylate) (PBMA) composite particles, in which the PS domain(s) were dispersed in a PBMA continuous phase, were produced by seeded polymerization for dispersions of n-butyl methacrylate (BMA) swollen PS particles in a wide range of PS/BMA ratios in the presence of NaNO2 as a water-soluble inhibitor. Moreover, in order to change the diameter of the composite particles at same PS/BMA ratio, PS/PBMA (1/150 w/w) composite particles were produced using five kinds of PS particles in a range of diameters from 0.64 to 3.27 μm as seeds. The percentages of the PS/PBMA composite particles having double and triple and over PS domains, which were thermodynamically unstable morphologies, increased with the increase in the diameter of BMA swollen PS particles. There was a clear influence of the size of the swollen particles on the morphology of the PS/PBMA composite particles produced.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003960000365
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  • 8
    Electronic Resource
    Electronic Resource
    Universal Correlations of Tc Ion Mass Scaling with Distance (2000)
    Springer
    Journal of superconductivity 13 (2000), S. 181-192 
    Details
    ISSN: 1572-9605
    Keywords: critical temperature ; correlations ; ion mass
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Notes: Abstract We present a short overview of the critical temperature correlations with different parameters for low and high T c superconductors. The overview underlines the importance of crystalline structure in determining the critical temperature value. The structure of copper-based superconductors is studied in comparison with low-temperature superconductors and a new correlation of the transition temperature is found. Namely, the layered structure, more exactly a certain distribution of the mass of the ions along the c-axis is the key factor in determining the “intrinsic” critical temperature, parameter introduced by Kresin et al. [4].
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007707116617
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  • 9
    Electronic Resource
    Electronic Resource
    Prevalence of cervical lesions in rheumatoid arthritis: cross-sectional study on 263 patients (2000)
    Springer
    Modern rheumatology 10 (2000), S. 211-215 
    Details
    ISSN: 1439-7609
    Keywords: Key words Rheumatoid arthritis ; Cervical lesion ; Atlantoaxial subluxation ; Subaxial subluxation ; Vertical subluxation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Spinal lesions in upper and sublaxilar cervical vertebrae were studied radiologically in 263 patients (25 men and 238 women) with rheumatoid arthritis (RA). Their average age was 58.9 years, and their disease duration was ranged from 6 months to 24 years (mean 13 years). Functional lateral views of the cervical spine were made. Atlantaxial subluxation (AAS) and vertical subluxation (VS) were evaluated as upper cervical lesions. Subaxilar subluxation (SAS) and endplate erosion were evaluated as subaxilar cervical lesions. One hundred and seventy-eight (67.7%) of the patients had a cervical lesion. Upper and subaxilar cervical abnormalities were recognized in 136 (51.7%) and 113 (43.0%) patients, respectively. There was no linkage between upper and subaxilar cervical lesions. While the prevalence of these lesions increased with time, the frequency was found to be over 50% within only 5 years from onset in patients with mutilating deformity. This prevalence tended to be associated with disease activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101650070004
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