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  • 1
    Digitale Medien
    Digitale Medien
    Glycosaminoglycans of Rat Cerebellum: I. Quantitative Analysis of the Main Constituents at Postnatal Day 6 (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 44 (1985), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: Isolated glycosaminoglycans (GAGs) were quantified biochemically in the cerebella of 6-day-old rats. 14C-Labeled hyaluronic acid (HA) and chondroitin-4-sulfate (C-4-S), added prior to isolation of GAGs from tissue, served as internal standards to allow correction for unknown losses during the purification procedure and exact quantification of GAGs in the intact tissue. Three main constituents—HA, chondroitin sulfate (CS), and heparan sulfate (HS)—were found at concentrations of 1.82, 1.52, and 0.76 μg/mg protein amounting to 44%, 37%, and 19% of the total GAG fraction, respectively. Incorporation of [3H]glucosamine precursor into GAGs was higher for HS (56% of incorporated precursor) and lower for HA (29%) and CS (15%). The specific activities of individual GAGs were 64.7 nCi/μg for HS, 14.2 for HA, and 8.3 for CS.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1985.tb12901.x
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  • 2
    Digitale Medien
    Digitale Medien
    Nitrogen-oxygen bond fission as the rate-determining step in the aqueous conversion of N-peptidyl-O-(p-nitrobenzoyl)hydroxylamines to p-nitrobenzoic acid and peptidylhydroxamic acids (1989)
    s.l. : American Chemical Society
    The @journal of organic chemistry 54 (1989), S. 5880-5883 
    Details
    ISSN: 1520-6904
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/jo00286a017
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  • 3
    Digitale Medien
    Digitale Medien
    Carbon-13 NMR investigations on the structure of .alpha.-keto acids in aqueous solution (1988)
    s.l. : American Chemical Society
    The @journal of organic chemistry 53 (1988), S. 214-216 
    Details
    ISSN: 1520-6904
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/jo00236a050
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  • 4
    Digitale Medien
    Digitale Medien
    Characterization of the human T cell response to antigen 5 from Vespula vulgaris (Ves v 5) (2005)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 35 (2005), S. 0 
    Details
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background The T cell reactivity to the major allergen of bee venom, phospholipase A2, has been thoroughly characterized. In contrast, only little is known about the human cellular response to major allergens from wasp venom.Objective To characterize the human T cell response to antigen 5 from Vespula vulgaris, Ves v 5.Methods Recombinant Ves v 5 was used to establish allergen-specific T cell lines (TCL) and T cell clones (TCC) from the peripheral blood of vespid-allergic and non-allergic individuals. Ves v 5-specific TCL were mapped for T cell epitopes using overlapping synthetic peptides representing the complete amino acid sequence of Ves v 5. Ves v 5-specific TCC were analysed for antigen-induced secretion of IL-4, IFN-γ and IL-10.Results Seventeen distinct T cell epitopes were recognized by allergic individuals among which Ves v 5181–192 was identified as a dominant T cell epitope. Partially different epitopes were observed in TCL from non-allergic subjects and the dominant epitope Ves v 5181–192 was not prevalent in these cultures. Ves v 5-specific TCC isolated from allergic individuals did not show the typical T helper type 2 (Th2)-like cytokine profile in response to specific stimulation, i.e. high amounts of IL-4 and low IFN-γ. TCC from non-allergic individuals showed a Th1-like cytokine pattern.Conclusions Our findings provide evidence that the allergic T cell response to Ves v 5 is not Th2-dominated and that different immunogenic sites on this major wasp venom allergen are recognized by allergic and non-allergic individuals.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2222.2005.02180.x
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  • 5
    Digitale Medien
    Digitale Medien
    Glycosaminoglycans of Rat Cerebellum: II. A Developmental Study (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 44 (1985), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: Total and individual glycosaminoglycans (GAGs) were determined in rat cerebellum in tissue explants at various postnatal ages. The major constituents of GAGs were chondroitin sulfate (CS), hyaluronic acid (HA), and heparan sulfate (HS). Dermatan sulfate (DS) and keratan sulfate (KS) could not be detected and therefore each amounts to 〈5% of all GAGs at all ages studied. HA was the prominent GAG during postnatal development and only a minor constituent at adult ages, whereas CS was the predominant GAG in adulthood. HS remained relatively constant throughout development. The incorporation of [3H]glucosamine into individual GAGs was highest for HS at postnatal day 6, whereas HA showed intermediate and CS the lowest levels of incorporation during the first postnatal week. All major GAGs showed the lowest incorporation values at adult ages.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1985.tb12902.x
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  • 6
    Digitale Medien
    Digitale Medien
    SOME REMARKS ON THE BEHAVIOR OF THE MAGNETOTELLURIC PHASE (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical prospecting 33 (1985), S. 0 
    Details
    ISSN: 1365-2478
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Geologie und Paläontologie , Physik
    Notizen: The magnetotelluric phase in the medium of incidence over a good conductor varies from its value at the conductor surface, usually close to 45°, to the characteristic standing-wave phaseshift of 90° over a distance of a few conductor skin-depths, much shorter than the vacuum wavelength at the frequencies considered. Over the top of a graben or at the surface of a two-layer structure the basement can be looked upon as the matrix. If the graben or the overburden is a better conductor it will carry an extra current density in phase with the electric field, thus giving rise to an additional magnetic field also in phase with the electric field. This drives the argument of the surface impedance toward smaller values. For a more resistive graben or overburden the current is depressed, corresponding to a reduction of the surface magnetic field by an amount in phase with the electric field. This effect drives the phase of the impedance to values above the characteristic 45° of a uniform conductor.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2478.1985.tb00774.x
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  • 7
    Digitale Medien
    Digitale Medien
    MULTIFOCAL FIBROSCLEROSIS: CUTANEOUS ASSOCIATIONS (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Australasian journal of dermatology 27 (1986), S. 0 
    Details
    ISSN: 1440-0960
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: There is a group of disorders characterized by simultaneous and progressive fibrosis of several discrete regions of the body. This disease complex, “multifocal fibrosclerosis”, most commonly involves the retroperitoneal and mediastinal compartments and may be accompanied by cutaneous lesions. In most cases the aetiology is unknown but there is good evidence, supported by the patient we describe, for a vasculitic origin in a significant proportion of patients.We report a case of multifocal fibrosclerosis associated with cutaneous lesions. These included livedo reticularis and recurrent, painful nodules and pustules on the legs and feet, which progressed to chronic ulceration. Histologically there was evidence of an underlying necrotising vasculitis.A review of the cutaneous changes that have been reported in association with multifocal fibrosclerosis allows speculation regarding the aetiology of the disease process.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-0960.1986.tb00279.x
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  • 8
    Digitale Medien
    Digitale Medien
    Association study of mast cell chymase polymorphisms with atopy (2005)
    Oxford, UK : Munksgaard International Publishers
    Allergy 60 (2005), S. 0 
    Details
    ISSN: 1398-9995
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background:  Atopic disorders are the result of complex interactions between genetic and environmental factors. Associations analyses between the promoter polymorphism rs1800875 in the mast cell chymase gene (CMA1) and atopy-related phenotypes have yielded inconsistent results.Methods:  We sequenced the CMA1 locus in 24 unrelated healthy individuals with serum IgE levels 〈50% percentile and 24 individuals with atopic eczema and serum IgE levels 〉90% percentile. Seven CMA1 single nucleotide polymorphisms (SNPs) were evaluated for evidence of associations with atopic phenotypes within a large population of German adults (n = 1875). Subjects were phenotyped by standardized questionnaires and interviews, skin prick testing and serum IgE measurements. Genotyping was performed using MALDI-TOF MS (Matrix-Assisted Laser Desorption Ionization–Time of Flight mass spectrometry).Results:  Promoter polymorphism rs1800875 was significantly associated with atopic eczema. No associations between any other single SNP and atopic phenotypes could be detected. Haplotype reconstruction revealed four of 128 possible haplotypes reaching estimated frequencies of 3% or more. Two of these haplotypes showed a borderline-significant association with atopic eczema, which did not remain significant after correction for multiple testing.Conclusions:  Results confirm previous observations of a significant association between the CMA1 promoter polymorphism rs1800875 and atopic eczema, but not with serum IgE levels, and support the hypothesis that CMA1 serves as candidate gene for atopic eczema.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1398-9995.2005.00879.x
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  • 9
    Digitale Medien
    Digitale Medien
    Lumbo-peritoneal shunt in non-hydrocephalic patients (1986)
    Springer
    Acta neurochirurgica 80 (1986), S. 90-92 
    Details
    ISSN: 0942-0940
    Schlagwort(e): Percutaneous lumbo-peritoneal shunt ; CSF rhinorrhoea ; pseudo tumour cerebri ; CSF shunt ; craniotomy ; syringomyelia
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A population of 41 non-hydrocephalic patients in whom a lumboperitoneal shunt (LPS) was inserted for various conditions is reviewed. 19 had persistent cerebro-spinal fluid rhinorrhoea following cranial injury, basal skull surgery or of unknown origin, 3 had recalcitrant benign intra-cranial hypertension, 14 had a persistent bulging craniotomy site after operations for intra-cranial tumours or head trauma, 4 had syringomyelia and 1 had a postoperative cervical meningocele. There was no shunt-related mortality. LPS was effective in treating the initial symptomatology in 31 patients. Further revision or removal of LPS were needed on 9 occasions in 8 patients showing shunt-related mechanical or infectious complications or persistent postural headaches. This report demonstrates the safety of the LPS procedure experienced in another population of 146 patients with communicating hydrocephalus operated on in the meantime. According to the authors' experience, the versatility of the clinical applications of LPS seems well established. LPS should be considered when a CSF diversion is required in patients showing absent or minimal ventricular enlargement in the CT scan.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01812280
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  • 10
    Digitale Medien
    Digitale Medien
    Increased UDP-Glucuronyltransferase in putative preneoplastic foci of human liver after long-term use of oral contraceptives (1985)
    Springer
    Naturwissenschaften 72 (1985), S. 277-278 
    Details
    ISSN: 1432-1904
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00448695
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