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  • 1
    Electronic Resource
    Electronic Resource
    Elevated interleukin-18 levels in bronchoalveolar lavage fluid of patients with eosinophilic pneumonia (2004)
    Oxford, UK : Munksgaard International Publishers
    Allergy 59 (2004), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Interleukin (IL)-18 can induce Th2 cytokine production particularly in collaboration with IL-2. Accumulation of Th2 cells and increased levels of Th2 cytokines are found in bronchoalveolar lavage fluid (BALF) from patients with eosinophilic pneumonia (EP). To evaluate the role of IL-18 in the pathogenesis of EP, we measured the concentration of IL-2, IL-12, IL-18, and Th2 cytokines in BALF from patients with EP.Methods:  The concentrations of interferon (IFN)-γ, IL-2, IL-5, IL-10, IL-12, IL-13, and IL-18 in BALF were measured in patients with idiopathic acute eosinophilic pneumonia (AEP), with idiopathic chronic eosinophilicpneumonia (CEP), with sarcoidosis and healthy volunteers (HV).Results:  The BALF concentrations of Th2 cytokines, IL-5, IL-10, and IL-13, were higher in patients with EP than in sarcoidosis and control. The IL-2 level in BALF was higher in EP than in sarcoidosis and control. The IL-18 and IL-12 (p40 + p70) levels were higher in patients with EP than sarcoidosis, while the level of IL-12 (p70) was below the detection limit in patients with EP. There was a significant correlation between IL-2 level and both IL-5 and IL-13 in BALF of patients with EP.Conclusions:  Our findings suggest that IL-18 may contribute to Th2 cytokine-dominant responses in patients with EP in collaboration with IL-2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.2004.00492.x
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  • 2
    Electronic Resource
    Electronic Resource
    Accumulation of CCR4-expressing CD4+ T cells and high concentration of its ligands (TARC and MDC) in bronchoalveolar lavage fluid of patients with eosinophilic pneumonia (2003)
    Oxford, UK : Munksgaard International Publishers
    Allergy 58 (2003), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Th2 cells are thought to be involved in eosinophilic inflammation of the lung. CC chemokine receptor 4 (CCR4) has been identified as a specific receptor for both thymus and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC), and is preferentially expressed on Th2 cells.Objective: Our aim was to evaluate the role of Th2 cells in the lung of patients with eosinophilic pneumonia (EP).Methods: The concentrations of TARC, MDC, and interleukin (IL)-5 were measured in bronchoalveolar lavage fluid (BALF) by ELISA. Proportion of CCR4-expressing CD4+ T cells (CCR4+ CD4+ T cells) was determined by flow cytometry.Results: TARC and MDC concentrations in BALF were higher in patients with EP than in normal subjects. The proportion of CCR4-expressing cells among CD4+ T cells was higher in BALF than in peripheral blood of patients with EP. There was a significant correlation between the number of CCR4+ CD4+ T cells and the levels of TARC, MDC, and IL-5 in BALF of patients with EP.Conclusions: Our data suggest that Th2 cells, which express CCR4 and its ligands (TARC and MDC), contribute to the pathogenesis of EP in the lung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.2003.00149.x
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  • 3
    Electronic Resource
    Electronic Resource
    Granulocyte-colony stimulating factor-producing esophageal carcinoma: serum level as a marker for monitoring the effects of treatment (2000)
    Springer
    International journal of clinical oncology 5 (2000), S. 328-333 
    Details
    ISSN: 1437-7772
    Keywords: Key words Granulocyte colony stimulating factor ; G-CSF-producing esophageal carcinoma ; Serum G-CSF level ; Adjuvant chemo-radiotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report here a case of granulocyte-colony stimulating factor (G-CSF)-producing esophageal carcinoma in a 66-year-old man. The International Union Against Cancer (UICC) staging was IV A, and a diagnosis of moderately differentiated squamous cell carcinoma was made, based on histopathology. The diagnosis was based on marked leukocytosis (41 500 leukocytes/mm3) and an elevated serum level of G-CSF (154 pg/ml). Immunofluorescent histochemistry and northern blot analysis confirmed the expression of G-CSF protein in cancer cells and its mRNA in cancer tissue. We paid special attention to any change in serum G-CSF levels during aggressive cancer treatment. Subtotal esophagectomy induced a significant decrease in G-CSF level. Adjuvant chemo-radiotherapy, targeting celiac lymph node metastasis, and radiotherapy, targeting solitary lung metastasis, together effectively maintained a low serum G-CSF level, despite a recurrence of the tumor in the lungs, in the form of multiple metastases, with an increase in serum G-CSF levels. The patient's clinical course suggested that serum G-CSF would be a useful marker for monitoring the effects of treatment on G-CSF-producing carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00012058
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  • 4
    Electronic Resource
    Electronic Resource
    Magnetic and Crystallographic Properties of Shape Memory Alloys Ni〈sub〉2〈/sub〉Mn〈sub〉1+x〈/sub〉Sn〈sub〉1-x〈/sub〉 (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 583 (May 2008), p. 119-129 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: X-ray powder diffraction and magnetization measurements were done on the magneticshape memory alloys Ni2Mn1+xSn1-x. The alloys with 0≤x≾0.4 crystallize in the cubic L21 structureand exhibit the ferromagnetic behavior. X-ray diffraction patterns indicate that the excess Mn atomsoccupy the Sn sites. Furthermore, magnetization measurements make clear that the Mn atoms,which substitute for Sn sites, are coupled antiferromagnetically to the ferromagnetic manganesesublattices. The alloys with 0.4≾x≤0.6 undergo a martensitic transition from the high temperatureL21 structure to the orthorhombic 4O one. These alloys show a variety of magnetic transitions. Amagnetic phase diagram of Ni2Mn1+xSn1-x system is discussed qualitatively on the basis of theinteratomic dependence of the exchange interactions
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/19/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.583.119.pdf
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  • 5
    Electronic Resource
    Electronic Resource
    Structural Chemistry of Alkaline Earth Aluminate Phosphors (2006)
    s.l. ; Stafa-Zurich, Switzerland
    Advanced materials research Vol. 11-12 (Feb. 2006), p. 43-46 
    Details
    ISSN: 1662-8985
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Crystal structures of SrAl2O4, BaAl2O4 and their solid solutions have been reviewed interms of the linkage pattern of [AlO4] tetrahedra. With SrAl2O4 the hexagonal-to-monoclinic phasetransformation occurs at 950K during cooling. The space group change from P63 to its subgroup P21eliminates the triad axis of the former phase, which involves a reduction in the symmetry of thetrigonally distorted rings. The hexagonal structures of SrAl2O4 and BaAl2O4 differ distinctly in thelinkage pattern of the [AlO4] tetrahedra. In the former structure, all of the tetrahedral rings areequivalent. In the latter, there are two types of tetrahedral rings; trigonal rings and asymmetrical ones.The trigonal rings, comprising 25% of the total number of rings, contain in their centers the Ba atomswith the special position. This implies that the triad axes exist in the centers of the rings, and hencethey are distorted trigonally as in the hexagonal SrAl2O4. On the other hand, the Ba atoms in theasymmetrical rings are located at the general position site. The structural disorder in Ba0.6Sr0.4Al2O4(space group P6322) was investigated by the combined use of Rietveld method and maximum-entropymethod. The electron density distribution was satisfactorily expressed by the split-atom model, inwhich the strontium/barium and oxygen atoms were split to occupy the lower symmetry sites
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/39/transtech_doi~10.4028%252Fwww.scientific.net%252FAMR.11-12.43.pdf
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  • 6
    Electronic Resource
    Electronic Resource
    Relationships between stream water chemistry and catchment geology in a mountainous region in Nagano Prefecture, Japan II: mid to southern part along the Median Tectonic Line (2000)
    Springer
    Limnology 1 (2000), S. 117-127 
    Details
    ISSN: 1439-863X
    Keywords: Key words Major ions ; Stream waters ; Water-rock interaction ; Geology ; Mapping ; Median Tectonic Line ; Nagano Prefecture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Major ion concentrations were determined for a large number of stream water samples collected from the mountainous area around the Median Tectonic Line (MTL) in the mid to southern part of Nagano Prefecture, Japan. The MTL, a major fault in the accretionary sedimentary complex to Japan Arc, extending linearly in the east–west direction in southwest Japan, bends in this area to south–north along the Akaishi Mountain chain. To the east of the MTL are, in order, Jurassic metamorphic rocks, including black/green schists and ultra-basic serpentinite (Sambagawa-Mikabu Belt); Jurassic mudstone with voluminous chert and calcite (Chichibu Belt); and Cretaceous sandstone (Shimanto Belt). On the other hand, on the west side of the MTL, Cretaceous granitic rocks (including tonalite and quartzdiorite) intruded and significantly metamorphosed the Jurassic sedimentary systems (Ryoke-Belt). In this area, more than 200 water samples were collected from small streams. Ion concentrations were analyzed by ion chromatography, whereby higher ion concentrations relatively rich in Mg2+ and Ca2+ and lower concentrations relatively rich in Na+ were obvious for the streams in Sambagawa-Mikabu, Chichibu, and Ryoke Belts, respectively. These tendencies could be explained by whole rock analysis on XRF (X-ray fluorescence spectrometry) as well as by a preliminary leaching experiment of the powdered rock samples with water. The results strongly suggested that the analytical data of the major ions in the stream waters might be compiled into a hydrogeochemical map, corresponding to the geological map.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s102010070017
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