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  • 1
    Electronic Resource
    Electronic Resource
    Behavior of high energy ions in the GAMMA 10 tandem mirror : Proceedings of the 12th topical conference on high temperature plasma diagnostics (1999)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 70 (1999), S. 834-837 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: In the GAMMA 10 tandem mirror, ion cyclotron range of frequency heating has been used effectively in the central cell. The ion temperature becomes several keV and an ion beta value is a few %. Semiconductor detectors are used for measurement of high energy protons in both parallel and perpendicular directions to the magnetic field line. Observed pitch angle distribution peaks near the cyclotron resonance layer and estimated pressure profile in the axial direction is consistent with the profile from a diamagnetic loop array. Strong temperature anisotropy can drive an Alfvén ion cyclotron (AIC) mode unstable. In a typical discharge, the temporal evolution of the endloss high energy ions has strong correlation with that of the AIC-mode amplitude. The enhancement of the loss of high energy ions due to the AIC mode is suggested. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1149491
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  • 2
    Electronic Resource
    Electronic Resource
    Probe wave system for studying excitation of Alfvén eigenmodes in the ion cyclotron range of frequency : Papers from the thirteenth topical conference on high temperature plasma diagnostics (2001)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 72 (2001), S. 398-401 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A probe wave system was constructed for studying the excitation of the Alfvén ion cyclotron (AIC) modes in the anchor cell of the GAMMA 10 tandem mirror. In the central cell, the AIC modes are spontaneously excited as axial eigenmodes due to the strong temperature anisotropy. In the anchor cell, the AIC modes were not observed though the anisotropy is the same as in the central cell. The axial profiles of the magnetic field strength and plasma parameters in the anchor cell are different from those in the central cell. Eigenmodes are excited externally in the AIC frequency range by injecting probe waves. This suggests the AIC modes are unstable in the anchor cell and grow to the detectable level when boundary conditions are realized. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1315638
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  • 3
    Electronic Resource
    Electronic Resource
    Transcriptomic analysis of metabolic changes by phosphorus stress in rice plant roots (2003)
    Oxford, UK : Blackwell Science Ltd
    Plant, cell & environment 26 (2003), S. 0 
    Details
    ISSN: 1365-3040
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: As most soil phosphates exist as insoluble inorganic phosphate and organic phosphates, higher plants have developed several strategies for adaptation to low phosphorus (P). These include the secretion of acid phosphatase and organic acids, induction of the inorganic phosphate (Pi) transporter and the substitution of some enzyme activities as alternative pathways to increase P utilization efficiency. It has been proposed that plants also have a ‘pho regulon’ system, as observed in yeast and Escherichia coli; however, the detail of the regulation system for gene expression on P status is still unclear in plants. To investigate the alteration of gene expression of rice roots grown under P-deficient conditions, a transcriptomic analysis was conducted using a cDNA microarray on rice. Based on the changes of gene expression under a –P treatment, the up-regulation of some genes due to P deficiency was confirmed . Some new important metabolic changes are suggested, namely: (1) acceleration of carbon supply for organic acid synthesis through glycolysis; (2) alteration of lipid metabolism; (3) rearrangement of compounds for cell wall; and (4) changes of gene expression related to the response for metallic elements such as Al, Fe and Zn.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3040.2003.01074.x
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  • 4
    Electronic Resource
    Electronic Resource
    Determinants of Bone Loss in a Rural Japanese Community: The Taiji Study (1998)
    Springer
    Osteoporosis international 8 (1998), S. 604-610 
    Details
    ISSN: 1433-2965
    Keywords: Key words:Anthropometrical factors – Bone mineral density – Change rate – Cohort study – Menstruation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: The objective of this study was to assess the rate of bone loss and characterize its determinants, among the inhabitants of Taiji, a rural Japanese community. A cohort of 2261 inhabitants aged 40–79 years was established using resident registration in 1992. Fifty men and 50 women in each of four age strata between 40 and 79 years were randomly selected and completed a self-administered risk factor questionnaire. Baseline bone density of lumbar spine and proximal femur was measured by dual-energy X-ray absorptiometry in 1993. BMD was measured again on the same participants in 1996. The rates of change of lumbar spine BMD in men in their 40s, 50s, 60s and 70s were 0.20%, 0.34%, 0.43% and 0.28% respectively. Rates in women were –0.35%, –1.02%, –0.10% and –0.20% respectively. At the femoral neck, rates of change in BMD among men in their 40s, 50s, 60s and 70s were 0.09%, –0.07%, 0.34% and 0.31% respectively. Femoral neck rates of change among women were –0.55%, 0.02%, 0.49% and –0.25% respectively. The rate of change of lumbar spine BMD was –0.24% in premenopausal women with regular periods, –1.99% in premenopausal women with irregular periods and –0.33% in postmenopausal women. Anthropometric measurements at baseline were also related significantly to change in bone density. Baseline weight and height were statistically significant predictors of bone loss rate.These data provide estimates of the rate of bone loss among Japanese men and women aged 40– 79 years. They suggest that body build and menstrual function in women are important determinants of bone loss.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001980050106
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  • 5
    Electronic Resource
    Electronic Resource
    Spontaneously reduced midgut malrotation: CT diagnosis (2000)
    Springer
    Abdominal imaging 25 (2000), S. 132-133 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Reduced—Midgut malrotation—CT reducible.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Midgut malrotation is a relatively rare congenital malformation that arises from an error of rotation and fixation of the midgut. We report a case of spontaneously reduced duodenal malrotation diagnosed by computed tomography and roentgenography after the ingestion of barium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619910031
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  • 6
    Electronic Resource
    Electronic Resource
    Biochemical Markers of Bone Turnover and Bone Loss at the Lumbar Spine and Femoral Neck: The Taiji Study (1999)
    Springer
    Calcified tissue international 65 (1999), S. 198-202 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Bone metabolic markers — Predictor — Osteoporosis — Epidemiology — Bone mineral density.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. The purpose of this study was to ascertain whether biochemical markers of bone turnover predict bone loss. The survey was carried out in Taiji, Wakayama Prefecture, Japan. From a list of inhabitants aged 40–79 years, 400 participants (50 men and 50 women in each of four age groups) were selected randomly. Bone mineral density (BMD) was measured, and blood and urine samples of all participants were examined to obtain values for eight biochemical markers: alkaline phosphatase (ALP), bone Gla protein (BGP), type I procollagen (carboxyterminal peptide of type I procollagen; PICP), cross-linked carboxyterminal telopeptide region of type I collagen (ICTP), and urinary excretion of calcium (Ca), phosphate (P), pyridinoline (Pyr), and deoxypyridinoline (D-Pyr). Each marker was evaluated as a predictor of the rate of bone change in lumbar spine and femoral neck BMD over a 3-year period. The value of Pyr was significantly related to the change of lumbar spine BMD in men (P= 0.009), and that of BGP was found to be significant in women (P= 0.045). By contrast, none of the bone markers significantly correlated with bone loss at the femoral neck. The coefficient of determination at the lumbar spine was 5% and 7% at the femoral neck only. We conclude that biochemical markers of bone turnover cannot predict bone loss rates in middle-aged or elderly Japanese men and women over a 3-year period with sufficient accuracy for use in clinical decision making.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002239900682
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  • 7
    Electronic Resource
    Electronic Resource
    Use of Intravenous γ-Globulin for Kawasaki Disease: Effects on Cardiac Sequelae (1997)
    Springer
    Pediatric cardiology 18 (1997), S. 19-23 
    Details
    ISSN: 1432-1971
    Keywords: Key words: Gamma-globulin treatment — Kawasaki disease — Cardiac sequelae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The administration of intravenous γ-globulin (IVGG) for Kawasaki disease was investigated throughout Japan in 1993 by obtaining information from pediatric departments in 2652 hospitals that had more than 100 beds. Of 11,221 reported patients, 8958 patients (79.8%) received IVGG treatment. Of all the patients to whom IVGG was administered, the most common total dose was 1000 mg/kg (36.3%) followed by 2000 mg/kg (16.9%) and 1200 mg/kg (16.8%). The treatment was started in 53.8% by day 5 of the illness and in 83.7% by day 7. The proportion of those with cardiac sequelae was higher among patients administered 〉2000 mg/kg or in those started on IVGG on day 9 of their illness or later. The possible reasons are (1) those who were more severely affected were treated with high-dose IVGG earlier; or (2) IVGG does not effectively prevent cardiac sequelae. We concluded that there is a risk of unfavorable effects with IVGG regarding cardiac sequelae when the IVGG dose is 〉2000 mg/kg or if IVGG is started on day 9 or later. We believe that only a randomized controlled trial, undertaken prospectively, can adequately address the question of the optimal use of IVGG.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002469900102
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  • 8
    Electronic Resource
    Electronic Resource
    Molecular analysis of the androgen receptor gene in 4 patients with complete androgen insensitivity (1998)
    Springer
    Archives of gynecology and obstetrics 261 (1998), S. 95-100 
    Details
    ISSN: 1432-0711
    Keywords: Key words: Androgen receptor ; Androgen insensitivity syndrome ; Point mutation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Androgen insensitivity syndromes are due to defects in the androgen receptor gene. In this study, we analyzed the androgen receptor gene in four cases with complete androgen insensitivity syndrome. In patient 1, one substitutional mutation [arginine (codon CGC) to cysteine (codon TGC) at position 774] of exon F was identified. This position was located in the hormone binding domain and appeared to be one hot spot of mutations because the mutations at the same position in several unrelated cases were reported before. In patient 2, one substitutional mutation [tyrosine (codon TAT) to cysteine (codon TGT) at position 571] of exon B was identified. This position was located in the DNA binding domain. In patients 3 and 4 (siblings), one substitutional mutation [arginine (codon CGA) to glutamine (codon CAA) at position 752] of exon E was identified. Taken together, these abnormalities might be related to the pathogenesis of complete androgen insensitivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004040050206
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  • 9
    Electronic Resource
    Electronic Resource
    Cardiac sympathetic dysfunction contributes to left ventricular remodelling after acute myocardial infarction (2000)
    Springer
    European journal of nuclear medicine 27 (2000), S. 1641-1649 
    Details
    ISSN: 1619-7089
    Keywords: Iodine-123 metaiodobenzylguanidine Cardiac sympathetic nervous system Acute myocardial infarction Reperfusion Left ventricular remodelling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. To investigate the role of the cardiac sympathetic nervous system in left ventricular remodelling, 50 patients with first-time acute myocardial infarction (AMI) and patency of the infarct-related artery after reperfusion underwent quantitative iodine-123 metaiodobenzylguanidine (MIBG) imaging at 4 days and 4 weeks (n=42), and quantitative technetium-99m tetrofosmin imaging at 2 days after AMI. They also underwent both ventriculography and coronary angiography on admission and about 4 weeks after AMI. On the basis of left ventricular end-systolic volume (LVESV), patients were divided into two groups. Patients with LVESV dilatation (n=20) had a significantly lower ejection fraction (P〈0.003) and a significantly higher severity score of 99mTc-tetrofosmin (P〈0.04), and total severity (P〈0.01), Δ extent (P〈0.007) and Δ severity (P〈0.0008) scores of MIBG than patients without LVESV dilatation (n=30). Δ severity score of MIBG was directly correlated with change in LVESV at 4 weeks (r=0.63, P〈0.0001). Stepwise linear discriminant function analysis showed that Δ severity score of MIBG (P〈0.0002) was the only discriminator of LVESV dilatation. Patients with LVESV dilatation had higher regional washout rates in both the infarct and the non-infarct zones than patients without such dilatation. Furthermore, no MIBG parameters changed significantly between 4 days and 4 weeks after AMI. In reperfused AMI, Δ severity score of MIBG was related to the degree of ventricular dilatation and was the only powerful discriminator of ventricular dilatation. These results suggest that cardiac sympathetic nervous abnormality might contribute to left ventricular remodelling in reperfused AMI. MIBG imaging may allow identification of reperfused AMI patients at high risk for left ventricular remodelling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002590000311
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  • 10
    Electronic Resource
    Electronic Resource
    Molecular analysis of familial androgen insensitivity syndrome due to replacement of glutamic acid 802 by lysine (2000)
    Springer
    Journal of human genetics 45 (2000), S. 342-345 
    Details
    ISSN: 1435-232X
    Keywords: Key words Familial complete androgen insensitivity syndrome ; Testicular feminization ; Androgen receptor gene ; Missense mutation ; X-linked recessive inheritance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We studied a Japanese family presenting at least two cases of complete androgen insensitivity syndrome (CAIS) and negative androgen receptor binding. The index subject showed a 46, XY karyotype and a complete female phenotype. For the purpose of further diagnosis and genetic counseling, molecular analysis of the androgen receptor (AR) gene was performed. Direct sequencing of the AR gene identified a mutation at nucleotide 2935 (A → G). This replacement was a novel missense mutation, resulting in the substitution of glutamic acid 802 by lysine which deleted a recognition site for EcoRI in exon 6 of the AR gene. We identified another affected individual, using chromosome and molecular analysis of the AR gene at exon 6. Furthermore, although heterozygote carriers could not be identified on clinical grounds, molecular identification of healthy individuals and heterozygote carriers in the family members provided definitive information for genetic counseling. We believe that the molecular analysis of familial CAIS is very informative for both the affected individuals and other family members.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100380070005
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