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  • 1
    Electronic Resource
    Electronic Resource
    Influence of preparation conditions on magnetic properties and aging behavior of rf diode sputtered GdTbCo films (1987)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 61 (1987), S. 3331-3333 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: GdTbCo films were rf diode sputtered from a composite target varying the argon pressure PAr and the substrate bias voltage Vb. Both the uniaxial magnetic anisotropy constant Ku and the aging behavior of the films depend strongly on the preparation parameters. The absolute maximum of Ku was obtained at Vb=−150 V. However, at this bias voltage nearly the highest oxidation rate of unprotected 100-nm-thick films was observed. Films of highest stability are obtained without any bias voltage. The oxidation rate is correlated with the Ar concentration in the films. It was argued recently that the anisotropy of sputtered films could depend on argon incorporation. Our results seem to rule out this mechanism since GdTbCo films prepared at zero bias show a relative Ku maximum in dependence on PAr where the argon concentration is near its absolute minimum. The magneto-optic Kerr rotation θK of the films can only be correlated with the Co concentration for zero bias films. Some additional variation depending on the bias voltage has been observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.338788
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  • 2
    Electronic Resource
    Electronic Resource
    Femtosecond four wave mixing spectroscopy of conjugated polymers (1993)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 99 (1993), S. 1597-1606 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Time-resolved four wave mixing (4WM) signals of conjugated polymers are calculated using a density matrix approach and the Hartree–Fock approximation. The influence of the Coulomb interaction as well as size effects on the nonlinear optical response are examined. For the Hückel model (no Coulomb interaction), quantum beats due to the coherent excitation of several band states are found for small sizes, and photon echo-like behavior is obtained for infinite size. The Coulomb interaction changes the nature of the response and gives rise to a broad delayed signal whose temporal profile is determined by the dephasing time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.465328
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  • 3
    Electronic Resource
    Electronic Resource
    Magnetic and magneto-optic properties of amorphous Gd-FeAu films (1986)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 59 (1986), S. 859-863 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Amorphous rare-earth transition metal alloys of composition (Gd1−xFex)1−yAuy with x=0.74, 0.77, and 0≤y≤0.40 were prepared by evaporation onto rotating glass substrates. The magnetic and magneto-optic properties have been investigated in the temperature range 4.2≤T≤TC revealing a decrease of the compensation and Curie temperature, the uniaxial anisotropy, and the Faraday and Kerr rotation with increasing gold content. The temperature behavior can be interpreted in terms of a mean-field analysis indicating a pronounced influence of the gold on the iron moment and the exchange constants. The temperature dependence of the Faraday rotation can be described in terms of the sublattice magnetizations inferred from the fit of the mean-field theory to the measured saturation magnetization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.336609
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  • 4
    Electronic Resource
    Electronic Resource
    Topical treatment of common warts in an HIV-positive patient with imiquimod 5% cream (2003)
    Oxford, UK : Blackwell Publishing
    Clinical and experimental dermatology 28 (2003), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Human immunodeficiency virus (HIV) infects and destroys crucial components of the immune system, leaving patients susceptible to a number of viral, bacterial and fungal diseases. Viral warts are caused by human papillomavirus infection and are a common skin disease that afflicts HIV-infected patients. Treatment modalities currently rely on destruction of the infected tissue or interruption of cell division; however, frequent recurrence is a particular challenge in HIV-infected patients. We report the case of a 41-year-old HIV-positive man with multiple common warts located on his hands and feet. Following 5 months of treatment with imiquimod, an immune response modifier, as a 5% cream, complete clearance of all warts was achieved. Mild erythma, itching and burning at the application site was observed in the early stages of treatment. The patient showed no relapse of warts at the 30-month follow-up visit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2230.28.s1.16.x
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  • 5
    Electronic Resource
    Electronic Resource
    Elevated expression of extracellular matrix metalloproteinase inducer (CD147) and membrane-type matrix metalloproteinases in venous leg ulcers (2002)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 147 (2002), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Background  Matrix metalloproteinases (MMPs) contribute to matrix remodelling in venous leg ulcers. Extracellular MMP inducer (EMMPRIN; CD147) has been reported to increase MMP expression, and membrane type 1 MMP (MT1-MMP) has been implicated in the activation of MMPs. Objectives  To examine whether and to what degree EMMPRIN, MMP-2, MT1-MMP and membrane type 2 MMP (MT2-MMP) are expressed in venous leg ulcers as well as the association with MMP activity. Methods  EMMPRIN, MMP-2, MT1-MMP and MT2-MMP were analysed by zymography and immunohistochemistry in biopsies from healthy skin and lesional tissue from venous leg ulcers. Results  Zymography provided direct evidence of increased proteolytic activity of MMP-2 in lesional skin in comparison with healthy controls. Immunostaining showed intense expression of EMMPRIN, MMP-2, MT1-MMP and MT2-MMP in dermal structures of venous leg ulcers, whereas only EMMPRIN and MMP-2 showed elevated expression in perivascular regions. Our findings indicate that venous leg ulcers are characterized by elevated expression of EMMPRIN, MMP-2, MT1-MMP and MT2-MMP. The immunohistological findings of skin alterations reflect the dynamic process of activation of soluble and membrane-bound MMPs, which may be highly induced by EMMPRIN. Conclusions  These data suggest for the first time that membrane-bound MMPs may favour enhanced turnover of the extracellular matrix and support unrestrained MMP activity in venous leg ulcers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2002.05025.x
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  • 6
    Electronic Resource
    Electronic Resource
    PANTOPRAZOLE AND 24-HOUR INTRAGASTRIC ACIDITY (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 7 (1993), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.1993.tb00077.x
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  • 7
    Electronic Resource
    Electronic Resource
    Single intravenous administration of the H+, K+-ATPase inhibitor BY 1023/SK&F 96022—inhibition of pentagastrin-stimulated gastric acid secretion and pharmacokinetics in man (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 4 (1990), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effects of the H+, K+-ATPase inhibitor BY 1023/SK&F 96022 on pentagastrin-stimulated acid secretion have been studied in healthy male volunteers (n= 12). The gastric acid response to submaximal pentagastrin-stimulation (0.6 μg/h/kg b.w.) was dose-dependently inhibited. A single dose of 5 mg decreased acid output by 22% while after 60 mg and 80 mg secretion was almost completely abolished.A good dose linearity was observed for AUC (0, 〉) and Cmax over the dose range from 5 to 80 mg. Elimination half-life, total clearance and volume of distribution of the parent compound were independent of the dose.The drug was well tolerated up to the highest dose of 80 mg. No clinically relevant influence was found on either laboratory screen or cardiovascular parameters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.1990.tb00468.x
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  • 8
    Electronic Resource
    Electronic Resource
    Inanspruchnahme medizinischer Versorgungsleistungen bei Patienten mit Fibromyalgiesyndrom (FMS) (2000)
    Springer
    Der Schmerz 14 (2000), S. 77-83 
    Details
    ISSN: 1432-2129
    Keywords: Schlüsselwörter Fibromyalgiesyndrom ; Versorgungssituation ; Inanspruchnahme ; Patientenzufriedenheit ; Keywords Fibromyalgia syndrome ; Health care utilization ; Treatment satisfaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Background: The purpose of the study was to examine the pain related health care utilization in patients with fibromyalgia syndrome. Methods: In a multicenter study six rheumatological hospitals associated in the rheumatological center of Heidelberg participated. All consecutive patients which fulfilled the ACR-criteria of fibromyalgia were assessed. Data about pain and related treatments were available from n=259 patients. Results: Patients suffered from chronic generalized pain on average for 5 years before being diagnosed as fibromyalgia. In most of the cases longlasting localized pain symptoms preceeded generalized pain. The spectrum of pain related treatments seems to be wide and arbitrary: 87% took questionable or excessive medication. 86% had some form of physiotherapy and 41% already experienced psychological treatment. 28% of the patients consulted dental surgeons including teeth extraction and 20% underwent multiple orthopaedic surgery. A mean of five different health care professionals were consulted regarding the pain problem. Treatment statisfaction rated by the patients was lowest with pharmacological and highest with psychological treatment and physiotherapy. Conclusions: The health care-seeking behavior of fibromyalgia-patients seems to be characterized by a multitude of different treatment attempts. Treatment was often invasive and focused on localized symptoms rather than on the generalized pain syndrome. An early confirmation of the diagnosis and a more evidence based treatment is strongly indicated.
    Notes: Zusammenfassung Fragestellung: Ziel der vorliegenden Studie ist die Analyse der Inanspruchnahme medizinischer Versorgungsleistungen von Fibromyalgiepatienten. Methode: Im Rahmen einer multizentrischen Erhebung in 6 Kliniken des Rheumazentrums Heidelberg wurden alle Patienten mit Fibromyalgiesyndrom (gemäß ACR 1990) hinsichtlich ihrer bisherigen Behandlungen befragt. Es liegen Daten von insgesamt n=259 Patienten vor. Ergebnisse: Im Durchschnitt hatten die Patienten bereits 5,4 Jahre vor der Diagnosestellung chronisch generalisierte Schmerzen (Diagnoselatenz). Dem Stadium der Schmerzgeneralisierung ging dabei ein über 10-jähriges Stadium lokalisierter Schmerzen voraus. Zahlreiche therapeutische Maßnahmen gegen die Schmerzsymptomatik wurden durchgeführt: 87% nahmen Medikamente – häufig eine fragwürdige Polymedikation. 86% erhielten aktive oder passive Physiotherapie und 41% wurden psychologisch behandelt. Bei 28% der Patienten wurde wegen der Schmerzen eine Zahnbehandlung durchgeführt. 20% wurden z. T. mehrfach orthopädisch operiert, nach der Schmerzgeneralisierung sogar signifikant mehr als vorher. Insgesamt wurden im Schnitt von den Patienten Ärzte in 5 verschiedenen Fachrichtungen konsultiert. Die Patienten selber beurteilten die medikamentöse Behandlung als am wenigsten hilfreich und passive Physiotherapie neben psychologischen Interventionen als am effektivsten. Schlussfolgerungen: Die Versorgungssituation der Patienten besteht aus einer Vielzahl unterschiedlicher Behandlungsversuche, welche jedoch eher auf lokalisierte Probleme als auf die generalisierte Schmerzsymptomatik abzielen. Eine frühzeitige Diagnosestellung und ein evidenzbasiertes Behandlungskonzept erscheinen dringend erforderlich.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004820050225
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  • 9
    Electronic Resource
    Electronic Resource
    Screening for and characterization of phospholipase A1 hypersecretory mutants of Tetrahymena thermophila (2000)
    Springer
    Applied microbiology and biotechnology 54 (2000), S. 390-396 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract We have described a procedure for the isolation of mutants of Tetrahymena thermophila with hyperscretion of phospholipase A1 (PLA1). Using random chemical mutagenesis, uniparental cytogamy, genetic crossing and a new, fast and effective screening procedure, four PLA1-hypersecretory mutants were isolated. The screening procedure is based on the formation of a halo appearing around cylindrical holes in a lecithin-containing agar plate filled with cell-free supernatants. About 3,940 clones were tested with this procedure in primary screening for hypersecretory features, of which 60 putative hypersecretory mutants were isolated, subcloned and tested in a secondary screening. Of these, four selected mutants showed 1.8–2.2 more PLA1 activity in the cell-free supernatants compared to the wild-type strain CU 438.1. Hypersecretion was only observable for PLA1; no increased activity for two other lysosomal enzymes could be detected. These hypersecretory mutants of T. thermophila can be very useful for increasing the yield of PLA1 in fermentation processes. This is particularly relevant because, in contrast to other phospholipases, PLA1 is not available on the commercial market for fine chemicals and little is known about the role of PLA1 in cell signaling and metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002530000405
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  • 10
    Electronic Resource
    Electronic Resource
    Insulin receptors in syncytitrophoblast and fetal endothelium of human placenta. Immunohistochemical evidence for developmental changes in distribution pattern (1994)
    Springer
    Histochemistry and cell biology 101 (1994), S. 277-285 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The localisation of insulin receptors (IR) was investigated on cryosections of human non-pathologic first trimester and full term placentae by indirect immunohistochemistry with three different monoclonal antibodies (MABS). In placentae from 6 to 10 weeks post-menstruation (p-m.), only syncytiotrophoblast was stained, predominantly that of mesenchymal villi and syncytial sprouts, which are areas of high proliferative activity. In placentae from 11 to 14 weeks p-m., endothelial cells commenced to react with the IR MABS and the syncytiotrophoblast was less intensely labelled than at weeks 6 to 10 p-m. In term placentae, the microvillous membrane of the syncytiotrophoblast showed only patches of weak immunoreactivity. In contrast, the endothelial cells in the placenta but not in the umbilical cord were strongly stained. The amniotic epithelium in the chorionic plate and fibroblasts in the stroma were conspicuously labelled. The data indicate: (1) the receptor density on villous syncytiotrophoblast decreases and that of fetal endothelium increases throughout gestation; (2) syncytiotrophoblast of human term placentae expresses a low level per unit area of surface IR; and (3) the majority of IR in human term placentae is located in fetal endothelium. Apart from yet unknown functional effects of maternal and fetal insulin at the placental barrier, the results suggest a growth promoting effect on the trophoblast of maternal insulin in first trimester as well as developmental effects of fetal insulin on the feto-placental vessels at term.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315915
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