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  • 1
    Digitale Medien
    Digitale Medien
    Minute liver cancer and concomitant esophageal varices: Detection and successful surgical treatment (1981)
    Springer
    World journal of surgery 5 (1981), S. 707-711 
    Details
    ISSN: 1432-2323
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Résumé Le traitement du cancer du foie associé à des varices oesophagiennes fut pratiqué chez 8 cirrhotiques qui présentaient une hypertension portale. Chez 5 malades, admis pour le traitement chirurgical de varices oesophagiennes, un cancer limité du foie fut décelé au moment de l'exploration opératoire. Chez 3 malades le diagnostic d'hépatome avait été porté avant l'intervention. L'exérèse de la tumeur du foie suivie d'une anastomose porto-cave fut pratiquée avec succès chez 6 malades. Le traitement simultané des varices oesophagiennes et du cancer du foie est possible quand la tumeur hépatique est découverte à un stade précoce. Le procédé le plus fiable pour aboutir à un diagnostic exact est représenté par l'artériographie hépatique. Notre propre expérience nous incite donc à recommander l'étude artériographique chez les cirrhotiques, particulièrement quand on envisage de traiter chirurgicalement les varices oesophagiennes.
    Notizen: Abstract Surgical treatment of liver cancer associated with esophageal varices was carried out in 8 cirrhotic patients with evidence of portal hypertension. In 5 patients admitted for elective surgery of esophageal varices, minute hepatomas were detected during the course of preoperative investigation. The remaining 3 patients were referred to our department when esophageal varices plus hepatoma had become evident. Extirpative treatment of the liver tumor followed by selective shunt operations were successfully carried out in 6 patients, and interrupted procedures were used in 2 patients. Treatment of both esophageal varices and liver cancer appears to be effective when the tumor in the liver is detected in an early stage. The most reliable diagnostic tool at the present time seems to be hepatic arteriography. Our experience strongly suggests that arteriographic studies should be seriously considered in cirrhotic patients, particularly when surgery for varices is being contemplated.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01657932
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  • 2
    Digitale Medien
    Digitale Medien
    Tauroursodeoxycholate and Cholestyramine Enhance Biliary Carcinogenesis in Hamsters (2000)
    Springer
    World journal of surgery 24 (2000), S. 22-26 
    Details
    ISSN: 1432-2323
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. The aim of this study was to examine whether tauroursodeoxycholate (TUDC) and cholestyramine resin (CR) enhance biliary carcinogenesis in the hamster model. A cholecystoduodenostomy with dissection of the extrahepatic bile duct on the distal end of the common duct was performed on Syrian hamsters. The hamsters were then divided randomly into 3 groups: control group, TUDC-treated group, and CR-treated group. All animals received N-nitrosobis(2-oxopropyl)amine (BOP) to initiate pancreaticobiliary cancer. The experiment was terminated at week 16 and the number of neoplastic lesions was counted microscopically. In the TUDC group, the intrahepatic biliary carcinogenesis was more accelerated than that observed in the control group, but no promoting effect was seen in the pancreas, gallbladder, or extrahepatic bile duct. In the CR group, both the intrahepatic biliary and the gallbladder carcinogenesis were inhibited compared with that observed in the control group and the TUDC group. TUDC enhanced the intrahepatic bile duct carcinogenesis, whereas CR inhibited both the intrahepatic bile duct and the gallbladder carcinoma. Bile acids were suggested to promote biliary carcinoma in the hamster model.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002689910005
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  • 3
    Digitale Medien
    Digitale Medien
    Hepatic resections for bilobar liver metastases from colorectal cancer (2000)
    Springer
    Journal of hepato-biliary-pancreatic surgery 7 (2000), S. 404-409 
    Details
    ISSN: 1436-0691
    Schlagwort(e): Key words Bilobar liver metastasis ; Colorectal cancer ; Hepatic resection
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The present study was performed to assess survival benefits in patients who underwent a hepatic resection for isolated bilobar liver metastases from colorectal cancer. Thirty-eight patients underwent a curative hepatic resection for isolated colorectal liver metastasis. Among them, 11 patients had bilobar liver metastases and 19 had a solitary metastasis. The remaining 8 patients had unilobar multiple lesions. We investigated survival in two groups those with bilobar and those with solitary metastatic tumors. Survival and disease-free survival were 36% and 18% at 5 years, respectively, in the patients with bilobar liver metastases, while these survivals were 43% and 34% in the patients with solitary liver metastasis. In the 38 patients, repeated hepatic resections were performed in 15 patients with recurrent liver disease. The 5-year survival and disease-free survival rates for these patients were 38% and 27%, respectively, after the second hepatic resections. Of the 11 patients with bilobar liver metastases, 5 underwent a repeated hepatic resection, and they all survived for over 42 months. Based on our observations, a hepatic resection was thus found to be effective even in selected patients with either bilobar nodules or recurrence in the remnant liver.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s005340070036
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  • 4
    Digitale Medien
    Digitale Medien
    Small-Cell Carcinoma of the Gallbladder: Report of a Case (2000)
    Springer
    Surgery today 30 (2000), S. 89-93 
    Details
    ISSN: 1436-2813
    Schlagwort(e): Key Words: gallbladder, small-cell carcinoma
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract: We report herein the case of an 81-year-old woman in whom a mass in the gallbladder was revealed by an ultra-sound examination conducted as part of a follow-up study for a silent gallstone. The mass showed evidence of invasion into the adjacent liver parenchyma. Under the tentative diagnosis of malignant neoplastic disease originating in the gallbladder, a cholecystectomy with partial hepatectomy was performed. Histological examination of the tumor confirmed a diagnosis of small-cell carcinoma of the gallbladder, which is considered to be a rare type of neoplasm.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/PL00010056
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  • 5
    Digitale Medien
    Digitale Medien
    Vascular access for intra-arterial chemotherapy for nonresectable hepatic tumor (1981)
    Springer
    Surgery today 11 (1981), S. 388-390 
    Details
    ISSN: 1436-2813
    Schlagwort(e): nonresectable hepatic tumor ; vascular accessgraft ; intraarterial chemotherapy ; liver cancer
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02468967
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  • 6
    Digitale Medien
    Digitale Medien
    Transparent box enables three dimensional viewing of CT imaging of the liver (1984)
    Springer
    Surgery today 14 (1984), S. 94-96 
    Details
    ISSN: 1436-2813
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We designed a transparent box to reconstruct cross sectional computed tomography (CT) imagings of the liver into a three dimensional form. The objective was to clearly visualize the area of lesion and to facilitate clinical teaching. This box (31.5×22.0×18.5 cm) is made of acrylic board containing 16 demountable panels layered horizontally at 10-mm intervals. The transparency of the CT film is projected onto these panels at each height of the liver, and findings including location of the tumor, main vessels and adjacent organs are outlined with an erasable marker. After completion of each tracing, the panels are replaced in the box and the total layer forms a completed picture of the CT findings. Since 1981, we have used this tool to assess resectability and/or to select adequate procedures for treating 54 patients with liver tumor. The solid picture gives an definite location of the tumor and its extension. In the clinical work-up, indication for surgery and a procedure of choice can be discussed by the team, using this visual aid.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02469609
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  • 7
    Digitale Medien
    Digitale Medien
    Small liver cancer (1983)
    Springer
    Surgery today 13 (1983), S. 32-36 
    Details
    ISSN: 1436-2813
    Schlagwort(e): small liver cancer ; early detection ; diagnostic sensitivity ; operative management
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We report eight cirrhotic patients with liver cancer of less than 2 cm in diameter, and who were successfully treated by surgery. The sensitivities of diagnostic procedures for small lesions showed that alpha-fetoprotein (AFP) was 75 per cent, radionuclide scanning 25 per cent, CT 33 per cent, ultrasonography 40 per cent and angiography 88 per cent. Serial measurement of AFP appears to be the most helpful for detection of hepatocellular carcinoma at the early stage, particularly in cirrhotic patients. Although hepatic imagings are of limited value for small hepatic tumors, those tools are often useful as a back-up for the routine tests but not for initial procedures. It should also be kept in mind that hepatic arteriography performed in the high risk group often leads to detection of small cancers. In cirrhotic patients with small hepatocellular carcinoma, surgical resection should be done, providing the clinical status and hepatocellular reserve are adequate.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02469687
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  • 8
    Digitale Medien
    Digitale Medien
    A newly designed clamp facilitates hepatic resection (1984)
    Springer
    Surgery today 14 (1984), S. 432-433 
    Details
    ISSN: 1436-2813
    Schlagwort(e): Inokuchi liver clamp ; hepatic resection
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We designed a new clamp (Inokuchi liver clamp), mainly used for partial or wedge resection of the liver. This clamp is gently curved and has 9 non-traumatic teeth with double step locking devices at the tips. This clamp proved to be most useful for limited hepatic resection, a common procedure for primary liver cancer associated with cirrhosis, however, it can also be used for major resections. From August 1981 to February 1984, this clamp was used by our surgical team in 45 resections of the liver for primary and secondary malignant tumors and benign hemangiomas.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02469553
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  • 9
    Digitale Medien
    Digitale Medien
    MRI facilitated a diagnosis of endometriosis of the rectum (2000)
    Springer
    Journal of gastroenterology 35 (2000), S. 784-788 
    Details
    ISSN: 1435-5922
    Schlagwort(e): Key words: endometriosis ; rectum ; magnetic resonance imaging (MRI)
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract: A 51-year-old pre-menopausal Japanese woman suffering from chronic lower abdominal pain was referred to our hospital. A barium enema showed a stenotic lesion in the recto-sigmoid region, and a pelvic computed axial tomography (CAT) scan revealed a thickened rectal wall. A colonoscopic examination showed the rectum to be constrictive, but the mucosa appeared to be intact. Magnetic resonance imaging (MRI) with T1 high-intensity revealed a cystic lesion in the thickened wall of the rectum, which led us to suspect possible bowel endometriosis. Part of the biopsy specimen showed endometrial epithelium within the interstitial layer of histologically normal mucosa; finally, endometriosis of the rectum was diagnosed. The patient became asymptomatic after the initiation of hormonal treatment and later experienced spontaneous menopause. MRI was effective for diagnosis and the patient did not undergo unnecessary laparotomy. Although bowel endometriosis is generally diagnosed by means of resected specimens, in our patient, diagnosis was made using MRI and biopsy, and hormonal therapy had an effective role as a bridge to menopause.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s005350070039
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  • 10
    Digitale Medien
    Digitale Medien
    Functions of peripheral 5-hydroxytryptamine receptors, especially 5-hydroxytryptamine4 receptor, in gastrointestinal motility (2000)
    Springer
    Journal of gastroenterology 35 (2000), S. 575-582 
    Details
    ISSN: 1435-5922
    Schlagwort(e): Key words: acetylcholine release ; in-vivo microdialysis ; in-vitro receptor autoradiography
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract: The multiple 5-hydroxytryptamine (5-HT, serotonin) receptor subtypes are distinguished. In this article, we described mainly the 5-HT4 receptor of four subtypes of functional 5-HT receptors, 5-HT1, 5-HT2, 5-HT3, and 5-HT4, recognized in the gastrointestinal tract. In-vivo microdialysis experiments determined that activation of the 5-HT4 receptor stimulated intestinal motor activity associated with a local increase in acetylcholine (ACh) release from the intestinal cholinergic neurons in the whole body of dogs. The 5-HT4 receptor-mediated response of ACh release in the antral, corporal, and fundic strips isolated from guinea pig stomach corresponds to the presence of 5-HT4 receptor in the myenteric plexus. In-vitro receptor autoradiograms of the stomach and colon indicate that the distribution of 5-HT4 receptors in human tissues is similar to that in the guinea pig, although density of 5-HT4 receptors in the myenteric plexus of human tissues is lower than that in guinea pig tissues. The 5-HT4 receptors located in the myenteric plexus may participate in gastrointestinal motility, and thus the 5-HT4 agonists and antagonists may be available for treatment of dysfunction of gastrointestinal motility.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s005350070056
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