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  • 2000-2004  (1)
  • 1965-1969  (2)
  • 1
    ISSN: 1437-2320
    Keywords: Key words Focal cerebral ischemia ; Programmed neuronal death ; Nimodipine ; Mannitol ; Cerebroprotection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The present study was conducted to evaluate the effects of nimodipine and mannitol on infarct size and on the amount of apoptosis after transient focal cerebral ischemia. Focal cerebral ischemia was induced in male Sprague-Dawley rats (weight 300–380 g) by transient occlusion of the right middle cerebral artery (MCAO) using an intraluminal thread model. All animals underwent ischemia for 2 h, followed by 24 h of reperfusion. Group I (n=16) was untreated. Group II (n=16) received 15% mannitol (1 g/kg as bolus) and group III (n=9) received 15 µg/kg/h nimodipine intravenously beginning 15 min prior to MCAO. Twenty-four hours after reperfusion, the brain was taken and sectioned in coronal slices. The slices were stained with H&E and with the transferase dUTP nick-end labeling (TUNEL) technique. Histopathological analysis revealed a significant (P〈0.05) decrease in infarct size in the striatum with both drugs: mannitol (group II) 25.4±5.9% and nimodipine (group III) 21.5±11.0% versus control (group I) 34.9±7.0% and in the cortex 2.7±2.0% (group II) and 6.3±2.4% (group III) versus control 14.4±9.0% (group I). The number of apoptotic cells was statistically lower in the therapy groups (group III 9.6, group II 25.8) versus control (group I 57.9) (Mann-Whitney-Wilcoxon U-test Z〉1.96, P〈0.05). This study indicates that mannitol and nimodipine provide neuroprotection by preventing both the necrotic and apoptotic components of cell death after transient focal cerebral ischemia and may be effective as neuroprotective drugs for cerebrovascular surgery.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 57 (1966), S. 81-84 
    ISSN: 1437-1596
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Sozial- und Präventivmedizin 11 (1966), S. 252-256 
    ISSN: 1420-911X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé La Suisse dispose de bases légales permettant de lutter contre la pollution de l'air provoquée par les véhicules à moteur. Cependant, les prescriptions actuelles, même clairement définies, ne seront pleinement efficaces que si toute infraction est sévèrement punie par les autorités juridiques et administratives.
    Notes: Zusammenfassung Es darf demnach festgehalten werden, daß in der Schweiz die rechtlichen Grundlagen für die Bekämpfung der Luftverunreinigung durch den Motorfahrzeugverkehr vorliegen. Die bestehenden klaren Vorschriften können indessen ihre volle Wirksamkeit nur dann entfalten, wenn in der Praxis der Gerichts-und Verwaltungsbehörden unnachsichtlich gegen Fehlbare eingeschritten wird.
    Type of Medium: Electronic Resource
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