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Rab7, a multifaceted GTP-binding protein regulating access to degradative compartments in eukaryotic cells (2000)

Bruckert, F. ; Laurent, O. ; Satre, M.

Springer

Protoplasma 210 (2000), S. 108-116

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ISSN: 1615-6102

Keywords: Rab7 protein ; Endocytosis ; Phagocytosis ; Lysosomal enzymes ; Cation-independent mannose 6-phosphate receptor

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Summary Small GTPases of the Rab subfamily localise to the cytoplasmic face of distinct membrane compartments and act as regulators of intracellular membrane traffic and transport vesicle formation. Among them, Rab7 controls the delivery of internalised material into degradative compartments and the acquisition of lysosomal hydrolases. This activity shapes the endocytic pathway of every cell type. In addition, this general role may adjust to serve specific needs in multicellular organisms.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01276850

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