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  • 1
    Electronic Resource
    Electronic Resource
    Different diagnostic approaches to adult candidates for cadaveric kidney transplantation in Europe (2000)
    Springer
    Transplant international 13 (2000), S. S263 
    Details
    ISSN: 1432-2277
    Keywords: Key words Kidney transplantation ; Pretransplant diagnostic evaluation ; Waiting list ; Geographic factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated which diagnostic procedures are mandatory for all transplant candidates irrespective of their individual situation in European transplant centres, how homogeneously these are applied and what centre characteristics determine differences in the diagnostic approach. A questionnaire was sent to European renal transplant centres asking which of 45 listed diagnostic procedures are mandatory for every transplant candidate. The 154 participating centres require 15.6 ± 5.6 (4–33) mandatory tests, with significantly less mandatory diagnostics in centres in the UK (8.5 ± 3.9) and Scandinavia (9.8 ± 2.3). Geographic location is the single significant factor in multifactorial analysis of possibly related factors. Detailed analysis revealed 16 tests that are required significantly less often in the north of Europe. There are significant differences in the evaluation of renal transplant candidates across Europe. In some parts of Europe transplant candidates are either investigated more discriminately or less comprehensively than in other regions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050338
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    FTY 720A mediates reduction of lymphocyte counts in human renal allograft recipients by an apoptosis-independent mechanism (2000)
    Springer
    Transplant international 13 (2000), S. S311 
    Details
    ISSN: 1432-2277
    Keywords: Key words FTY 720A ; Transplantation ; Immunosuppression ; Lymphopenia ; Apoptosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The novel immunosuppressive compound FTY 720A posseses a mode of action which is different from all other immunosuppressive drugs. The most prominent feature is a reversible decrease in peripheral lymphocyte counts observed in animal experiments. We investigated in the first human trial (phase 1) whether FTY 720A induces apoptosis of peripheral blood mononuclear cells (PBMC) in stable renal allograft recipients. Monitoring of lymphocyte counts revealed a significant and dose-dependent decrease within 6 h post-FTY 720A dose: placebo 5.1 %; 0.25 mg 36.4 %; 0.5 mg 40.8 %; 0.75 mg 39.4 %; 1 mg 45.8 %; 2 mg 67.2 %; 3.5 mg 64.9 %. PBMC apoptosis rates did not change, as determined before intake of FTY 720A and 2 h, 6 h, 24 h and 96 h post-FTY 720A dose. We detected no significant difference in apoptosis rates between patients who received placebo or FTY 720A. However, in vitro experiments showed that high concentrations of FTY 720 A induced apoptosis in human PBMC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050350
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Prognostic value of the Banff classification (2000)
    Springer
    Transplant international 13 (2000), S. S106 
    Details
    ISSN: 1432-2277
    Keywords: Key words Banff classification ; Graft survival ; Prognostic value ; Rejection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We evaluated whether classification of renal allograft biopsies according to the Banff schema is a predictive parameter for graft survival. All patients who received renal transplants between 1980 and 1994 at the University of Erlangen-Nuremberg (n = 1141) were included. Patients who had undergone a renal biopsy (n = 306) were divided into groups according to the Banff classification. We observed a correlation (P 〈 0.05) between biopsy findings and the following patient characteristics: donor/recipient age, donor/recipient gender, panel reactive antibodies, maintenance immunosuppression, and primary renal disease. Compared to patients who did not undergo renal biopsy (55.9 %), 5-year graft survival was reduced in patients with moderate acute rejection defined by tubulitis (20.6 %, P = 0.03) or arteritis (0 %; P 〈 0.0001) and in patients with severe acute rejection (24.4 %, P 〈 0.0001). Conclusions: (1). The Banff classification is a predictive parameter for renal allograft survival. (2). Certain characteristics predispose patients to certain biopsy findings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050291
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    Paper (German National Licenses)
    Fulltext
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