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  • 1
    Electronic Resource
    Electronic Resource
    HCO3 − Transport in a Mathematical Model of the Pancreatic Ductal Epithelium (2000)
    Springer
    The journal of membrane biology 176 (2000), S. 77-100 
    Details
    ISSN: 1432-1424
    Keywords: Key words: Pancreatic duct cells — Mathematical model — HCO−3 secretion — Cl− secretion — Cystic fibrosis transmembrane conductance regulator
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract. We have used computer modeling to investigate how pancreatic duct cells can secrete a fluid containing near isotonic (∼140 mm) NaHCO3. Experimental data suggest that NaHCO3 secretion occurs in three steps: (i) accumulation of HCO− 3 across the basolateral membrane of the duct cell by Na(HCO3) n cotransporters, Na+/H+ exchangers and proton pumps; (ii) secretion of HCO− 3 across the luminal membrane on Cl−/HCO− 3 antiporters operating in parallel with Cl− channels; and (iii) diffusion of Na+ through the paracellular pathway. Programming the currently available experimental data into our computer model shows that this mechanism for HCO− 3 secretion is deficient in one important respect. While it can produce a relatively large volume of a HCO− 3-rich fluid, it can only raise the luminal HCO− 3 concentration up to about 70 mm. To achieve secretion of 140 mm NaHCO3 by the model it is necessary to: (i) reduce the conductive Cl− permeability and increase the conductive HCO− 3 permeability of the luminal membrane of the duct cell, and (ii) reduce the activity of the luminal Cl−/HCO− 3 antiporters. Under these conditions most of the HCO− 3 is secreted via a conductive pathway. Based on our data, we propose that HCO− 3 secretion occurs mainly by the antiporter in duct segments near the acini (luminal HCO− 3 concentration up to ∼70 mm), but mainly via channels further down the ductal tree (raising luminal HCO− 3 to ∼140 mm).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00232001077
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  • 2
    Electronic Resource
    Electronic Resource
    Haemostatic management of intraoral bleeding in patients with congenital deficiency of α2-plasmin inhibitor or plasminogen activator inhibitor-1 (2004)
    Oxford, UK : Blackwell Science Ltd
    Haemophilia 10 (2004), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary.  Haemostatic management of intraoral bleeding was investigated in patients with congenital α2-plasmin inhibitor (α2-PI) deficiency or congenital plasminogen activator inhibitor- 1 (PAI-1) deficiency. When extracting teeth from patients with congenital α2-PI deficiency, we advocate that 7.5–10 mg kg−1 of tranexamic acid be administered orally every 6 h, starting 3 h before surgery and continuing for about 7 days. For the treatment of continuous bleeding, such as post-extraction bleeding, 20 mg kg−1 of tranexamic acid should be administered intravenously, and after achieving local haemostasis 7.5 mg kg−1 of tranexamic acid should be administered orally every 6 h for several days. In addition, when treating haematoma caused by labial or gingival laceration or buccal or mandibular contusion, haemostasis should be achieved by administering 7.5–10 mg kg−1 of tranexamic acid every 6 h. Tranexamic acid can also be used for haemostatic management of intraoral bleeding in patients with congenital PAI-1 deficiency, but is less effective when compared with use in patients with congenital α2-PI deficiency. Continuous infusion of 1.5 mg kg−1 h−1 of tranexamic acid is necessary for impacted tooth extraction requiring gingival incision or removal of local bone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2516.2004.00914.x
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  • 3
    Electronic Resource
    Electronic Resource
    A histomorphometric analysis on bone dynamics in denture supporting tissue under continuous pressure (2002)
    Oxford UK : Blackwell Science Ltd
    Journal of oral rehabilitation 29 (2002), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The purpose of this study was to investigate bone dynamics under a denture base, in relation to the intensity of continuous pressure exerted through it to the denture supporting tissue. Two hundred and fifty male rats of Wistar strain were divided into five groups, four of which wore experimental dentures to load continuous pressure of 0·0, 1·0, 10·0 or 20·0 kPa to the molar region of the hard palate. The fifth group was the non-denture-wearing group. Fluorescent labelled palatal bone tissue was stained with Villanueva bone stain and was prepared for the undecalcified grinding section. In the 0·0 kPa group whose mucosa was covered with denture base, although no bone resorption was observed, bone formation was inhibited up to 4 weeks after the denture insertion. Bone dynamics in the 1·0 kPa group was similar to those in the 0·0 kPa group. In the 10·0 and 20·0 kPa groups, bone resorption was observed until 3 and 2 weeks after the denture insertion, and the amount of bone resorption (AoBR) was 24 ± 17 and 35 ± 21 lm, respectively. After bone resorption in these groups, although osteoid formation increased earlier than 0·0 kPa group, mineralization showed a similar time course with 0·0 kPa group. In conclusion, bone dynamics under a denture base caused by continuous pressure exerted through it was revealed to show a time course depending on the intensity of the initial pressure. Amount of bone resorption was also revealed to correspond to the intensity of the initial pressure. Bone formation following bone resorption did not cause equivalent recovery of the bone surface level to the level observed in the case without bone resorption.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2842.2002.00799.x
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  • 4
    Electronic Resource
    Electronic Resource
    A histomorphometric analysis on bone dynamics in denture supporting tissue under continuous pressure in streptozotocin-induced diabetic rat (2001)
    Oxford UK : Blackwell Science Ltd
    Journal of oral rehabilitation 28 (2001), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The purpose of this study was to investigate bone dynamics in denture supporting tissue under continuous pressure in the diabetic condition by using bone histomorphometry in relation to initial intensity of continuous pressure exerted through the denture base. The experimental denture base, which was designed to load initial continuous pressure of 0·0, 1·0, 10·0 or 20·0 kPa to the denture supporting tissue, was applied to the molar region of hard palate of streptozotocin-induced diabetic rats. Fluorescent labelled palatal bone tissue was stained with Villanueva bone stain and was prepared for the undecalcified grinding section. In 0·0 kPa group, no bone resorption was observed and bone formation was transiently inhibited after the denture insertion. In 1·0 kPa group, although no bone resorption was observed, the beginning of bone formation after the inhibition of bone formation was later than that in 0·0 kPa group and bone formation dynamics after the resumption of bone formation was similar to that in 0·0 kPa group. In 10·0 and 20·0 kPa groups, bone resorption was observed until 3 and 4 weeks, respectively, and the amount of bone resorption for each group was 60 ± 16 and 87 ± 18 μm, respectively. The resumption of bone formation in 10·0 and 20·0 kPa groups were observed at the same stage with 1·0 kPa group, and the bone formation dynamics after the resumption of bone formation in 10·0 and 20·0 kPa groups were also similar to that in 0·0 kPa group. From the results of this study, it was revealed that bone formation following bone resorption did not cause equivalent recovery of the bone surface level to the level observed in the case without bone resorption in the diabetic condition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2842.2001.00694.x
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  • 5
    Electronic Resource
    Electronic Resource
    Histomorphometric analysis on bone dynamics in denture supporting tissue under masticatory pressure in rat (2001)
    Oxford UK : Blackwell Science Ltd
    Journal of oral rehabilitation 28 (2001), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The bone dynamics under denture base has not been clarified sufficiently. The purpose of this study was to evaluate histomorphometrically the bone dynamics in denture supporting tissue with relation to the intensity of the masticatory pressure. The removable denture bases, which exerted four different regulated masticatory pressures (0·0, 1·0, 20·0 or 40·0 kPa), were inserted to the hard palate of the molar region of 22-week-old rats. The palatal tissues were excised from 1 to 12 weeks after denture insertion at intervals of 1 week and embedded in methyl-methacrylate. No bone resorption was observed throughout the experimental period in the 0·0 and 1·0 kPa groups. In the 1·0 kPa group compared with the 0·0 kPa group, bone formation parameters except for bone formation rate significantly increased at 4 weeks, but there was no significant difference between these groups in the other experimental periods. In the 20·0 and 40·0 kPa groups, bone resorption was observed until 3 and 5 weeks, respectively, and the amounts of bone resorption (AoBR) were 45 ± 25 and 104 ± 21 μm, respectively. After bone resorption, bone formation parameters in these two groups showed transiently significant decrease compared with the 0·0 kPa group, but were the same time course as the 0·0 kPa group following this decrease. In conclusion, masticatory pressure caused different time courses of the bone dynamics in denture supporting tissue depending on the initial intensity of the pressure. The AoBR responded to the initial intensity of masticatory pressure. Bone formation following bone resorption did not cause equivalent recovery of the bone surface level to the level observed in the case without bone resorption in the present study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2842.2001.00700.x
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  • 6
    Electronic Resource
    Electronic Resource
    Sequential changes of cholinergic and dopaminergic receptors in brains after 6-hydroxydopamine lesions of the medial forebrain bundle in rats (2000)
    Springer
    Journal of neural transmission 107 (2000), S. 873-884 
    Details
    ISSN: 1435-1463
    Keywords: Keywords: Cholinergic receptors ; high-affinity choline uptake sites ; dopamine D2 receptors ; receptor autoradiography ; 6-hydroxydopamine ; nigrostriatal pathway ; rat.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. We studied sequential changes in muscarinic cholinergic receptors, high-affinity choline uptake sites and dopamine D2 receptors in the brain after 6-hydroxydopamine lesions of the medial forebrain bundle in rats. The animals were unilaterally lesioned in the medial forebrain bundle and the brains were analyzed at 1, 2, 4 and 8 weeks postlesion. [3H]Quinuclidinylbenzilate (QNB), [3H]hemicholinum-3 (HC-3) and [3H]raclopride were used to label muscarinic cholinergic receptors, high-affinity choline uptake sites and dopamine D2 receptors, respectively. The degeneration of nigrostriatal pathway produced a transient decrease in [3H]QNB binding in the parietal cortex of both ipislateral and contralateral sides at 2 and 8 weeks postlesion. [3H] QNB binding also showed a mild but insignificant decrease in the ipsilateral striatum throughout the postlesion periods. No significant change was observed in the substantia nigra (SN) of both ipsilateral and contralateral sides throughout the postlesion periods. In contrast, [3H]HC-3 binding showed no significant change in the parietal cortex of both ipsilateral and contralateral sides during the postlesion. However, [3H]HC-3 binding was upregulated in the ipsilateral dorsolateral striatum throughout the postlesion periods. The ventromedial striatum also showed a significant increase in [3H]HC-3 binding at 1 week and 2 weeks postlesion. On the other hand, no significant change in [3H]raclopride binding was found in the parietal cortex of both ipsilateral and contralateral sides during the postlesion. [3H]Raclopride binding showed a conspicuous increase in the ipsilateral striatum (35–52% of the sham-operated values in the lateral part and 39–54% in the medial part) throughout the postlesion periods. In the contralateral side, a mild increase in [3H]raclopride binding was also found in the striatum (10–15% of the sham-operated values in the lateral part and 22% in the medial part) after lesioning. However, a significant decline in [3H]raclopride binding was observed in the ipsilateral SN and ventral tegmental area during the postlesion. The present study indicates that 6-hydroxydopamine injection of medial forebrain bundle in rats can cause functional changes in high-affinity choline uptake site in the striatum, as compared with muscarinic cholinergic receptors. Furthermore, our studies demonstrate an upregulation in dopamine D2 receptors in the striatum and a decrease in the receptors in the SN and ventral tegmental area after the 6-hydroxydopamine injection. Thus, these findings provide further support for neurodegeneration of the nigrostriatal pathway that occurs in Parkinson's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007020070039
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  • 7
    Electronic Resource
    Electronic Resource
    Protective Effect of Riluzole on MPTP-Induced Depletion of Dopamine and Its Metabolite Content in Mice (2000)
    Springer
    Metabolic brain disease 15 (2000), S. 193-201 
    Details
    ISSN: 1573-7365
    Keywords: MPTP ; riluzole ; pargyline ; MK-801 ; dopamine ; mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The neuroprotective effects of riluzole (2-amino-6-trifluoromethoxy benzothiazole), a Na+ channel blocker with antiglutamatergic activity, MK-801, a blocker of N-methyl-D-aspartate (NMDA) receptors and monoamine oxidase (MAO) inhibitor pargyline were compared in the model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced depletion of dopamine and its metabolite 3, 4-dihydroxyphenylacetic acid (DOPAC) levels in mice. The mice received four intraperitoneal injections of MPTP (10 mg/kg) at 1-hr intervals and then the brains were analyzed at 1, 3 and 7 days after the treatments. Dopamine and DOPAC levels were significantly decreased in the striatum from 1 day after MPTP treatments. A severe depletion in dopamine and DOPAC levels was found in the striatum 3 and 7 days after MPTP treatments. Riluzole dose-dependently antagonized the MPTP-induced decrease in dopamine and DOPAC levels in the striatum. Pargyline also protected against MPTP-induced decrease in dopamine levels in the striatum. However, this drug showed no significant change in the striatal DOPAC levels. On the other hand, MK-801 failed to protect against MPTP-induced decrease in dopamine levels in the striatum. However, MK-801 reversed the MPTP-induced decrease in DOPAC levels. These results suggest that riluzole can protect against MPTP-induced striatal dopamine and DOPAC depletion in mice. This protective effect may be caused by inactivation of voltage-dependent Na+ channels by riluzole. Furthermore, the present study suggests that the activation of NMDA receptors does not mainly contribute to MPTP-induced neurodegeneration, whereas MAO, especially MAO type B(MAO-B) plays a crucial role in MPTP-induced degeneration of the nigrostriatal dopaminergic neuronal pathway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1011111708901
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  • 8
    Electronic Resource
    Electronic Resource
    Multiple nuclear Bragg scattering (2000)
    Springer
    Hyperfine interactions 126 (2000), S. 435-441 
    Details
    ISSN: 1572-9540
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Multiple nuclear resonant scattering from an 57FeBO3 single crystal has been observed in the three-beam case. A change of the lifetime and a modulation of the quantum beat were observed in our study. The high brilliance of synchrotron radiation and the high perfection of the synthetic 57FeBO3 single crystal enabled us to observe such an effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1012647418224
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