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  • 1
    ISSN: 1432-0533
    Keywords: Key words Oligodendroglioma ; Neurofilament ; Glial fibrillary acidic protein ; Survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have characterized a new polyclonal antibody against heavy chain (H) of neurofilament which can be used to demonstrate neurofilament H in normal brain tissue and oligodendroglioma cells immunocytochemically and immunochemically. Using this antibody we found neurofilament H-immunoreactive tumor cells in 13 oligodendrogliomas (6 WHO grade II, 7 WHO grade III) out of 84 oligodendrogliomas investigated (59 WHO grade II and 25 WHO grade III). Double immunolabeling and confocal laser scanning microscopy showed colocalization of neurofilament H and glial fibrillary acidic protein in certain oligodendroglioma cells. Colocalization of neurofilament and synaptophysin was observed only rarely. The results support the notion that oligodendrogliomas consists of a heterogeneous cell population displaying various stages of differentiation and dedifferentiation. The occurrence of neurofilament H-immunoreactive tumor cells in oligodendrogliomas is not related to the survival of the patients.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 142 (2000), S. 1071-1072 
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Rechtsmedizin 10 (2000), S. 110-113 
    ISSN: 1434-5196
    Keywords: Schlüsselwörter Spongiforme Leukenzephalopathie ; Heroinabusus ; Chinesing ; Keywords Heroin addicts ; Leucoencephalopathy ; Chinesing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: A 37-year-old male heroin addict who also performed inhalation of the white smoke obtained by heating heroin on tinfoil (chinesing or chinese blowing), presented with disturbance of consciousness, behavioural changes and headache. Tetraparesis developed rapidly with flexory hypertonia of the upper and extensor hypertonia of the lower limbs and within 17 days the patient died of respiratory failure. The neuropathological examination of the brain showed a severe cerebral edema, signs of hypoxic encephalopathy and a spongiform leucoencephalopathy with axonal degeneration only in the most severely affected areas. The pathogenesis of this neurological complication in heroin addicts performing chinese blowing is unknown and toxic elements could not be detected yet.
    Notes: Ein 37 Jahre alter Mann, bei dem anamnestisch die Inhalation von erhitztem Heroin (chinesing oder chinese blowing) bekannt war, wurde wegen Bewußtseinsstörungen mit Verhaltensauffälligkeiten und Kopfschmerzen in eine neurologische Klinik eingewiesen. Dort entwickelte sich rasch eine Mittelhirnsymptomatik und der Patient verstarb nach 17 Tagen an einer respiratorischen Insuffizienz. Die neuropathologische Untersuchung des Gehirns ergab ein Hirnödem mit Zeichen der hypoxischen Enzephalopathie und eine spongiforme Leukenzephalopathie im Groß- und Kleinhirn, die lediglich in den am schwersten geschädigten Arealen eine axonale Degeneration zeigte.
    Type of Medium: Electronic Resource
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